Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"mesenchymal stem cell differentiation"”.
-
Complementary Strategies to Promote Mesenchymal Stem Cell Differentiation for Ligament Tissue Engineering
… graft choices for repair of ACL disruptions. The cell-based approach to construct engineered ligament grafts presented herein involves the culture of mesenchymal stem cells (MSC) on biodegradable, fibrous polymeric scaffolds to promote tissue formation. Multipotent MSCs are advantageous because of …
-
Elucidating Cause-Effect Relationships between Extracellular Matrix Signaling and Mesenchymal Stem Cell Differentiation
Mesenchymal stem cell (MSC) differentiation is known to be influenced by a range of environmental stimuli. MSC-based bone regeneration strategies would benefit from the identification of scaffold material properties which intrinsically promote osteoblast lineage progression. The aim of this work …
-
Targeted mesenchymal stem cell differentiation from induced pluripotent stem cells for therapeutic application
<p>Over the past decade, mesenchymal stem cells have increasingly gained interest as a cell source for the treatment of a variety of diseases. This is because they play several roles in tissue homeostasis and regeneration, such as altering the immune response to limit inflammation, aiding tissue …
-
The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… is known to have effects on digestive system, cardiovascular system, and kidney function. The authors studied the effects of ethyl acetate extract of poncirus trifoliata on the activities of osteoblast and animal model. Effects of osteoblastic differentiation were measured by alkaline …
-
A Multivalent Ligand Display System with Plant Viruses: A Novel Approach Towards Studying Spatial Effects of Cell Adhesion Ligands
… (i.e. a tripeptide motif, Arg-Gly-Asp, for cell adhesion) with different spatial densities with nanometer precision. Furthermore, given the immense diversity of viruses and virus-like particles, one could find an ideal model that is well-suited to generate a variety of spatial arrangements …
-
Identifizierung und funktionelle Analyse der humanen Xylosyltransferase I- und II-Promotoren
… Both XT isoforms represent key enzymes in extracellular matrix assembly and remodeling and do also play a major role in various pathological processes. The xylosyltransferases show a high degree of homology in structure and function. Nevertheless, they have divergent expression levels in …
-
Strategies for the Fabrication of Cellularized Micro-Fiber/Hydrogel Composites for Ligament Tissue Engineering
… biomaterial scaffolds to support the growth and differentiation of mesenchymal stem cells toward many tissue lineages including ligament. However, these micro-fiber networks do not possess suitable sizes and shapes for a ligament application and cannot support cell infiltration. The objective of …
-
Materials and Nanostructured Coatings for Soft Tissue Regeneration
… treatment or organ transplantation although cellular therapies based on progenitor cell injection are still problematic. Myocardial Tissue Engineering (MTE) is a Regenerative Medicine approach, able to integrate cell therapy with the use of polymeric substrates (myocardial scaffolds or heart …
-
Development and characterisation of a heparinised fibrin hydrogel as a delivery vehicle for regenerative medicine
… 70% after three days of 3D culture for all three cell lines evaluated, namely human umbilical vein endothelial cells (HUVECs), human dermal fibroblasts and adipose tissue-derived stem cells (ADSCs) as indicated by live/dead assays. A 3D HUVEC spheroid-based angiogenesis assay found that FH …