Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"mesenchymal stem cell"”.
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
… by harnessing the developmental potential of stem cells to restore structure and function to damaged tissues. The recently discovered interdependency of cell phenotype and biophysical environment has created a paradigm shift in cell biology. This dissertation introduces a dynamic in vitro …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
… model for studying molecular mechanisms of stem cell (SC) fate determination. While the epithelial SCs are well studied within this model, the identification and characterisation of a mesenchymal SC (MSC) population has yet to be defined. Aims This study aims to identify the molecular …
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
… efforts to engineer replacement tissues, and mesenchymal stem cells (MSCs), which can undergo chondrogenesis, have emerged as a promising cell source. To date however, the functional properties of MSC-based constructs remain lower than those of the native tissue and of chondrocyte-based …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… the organization and alignment of the extracellular matrix (ECM) in developing and mature tissues, where the organization gives the tissue its unique functional properties. This dissertation will discuss research that is fundamental to the understanding of the interaction of cells with the …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
Mesenchymal stem cells (MSCs) are currently under investigation as repair agents in the preservation of cardiac function following myocardial infarction (MI). However concerns have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, …
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MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that can self-renew and differentiate into cells from the mesodermal cell lineage. Under specific conditions, MSCs are known to transdifferentiate into the neuronal cell lineage. The aim of this study was to investigate if specific …
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Self-assembling silk hydrogels for mesenchymal stem cell and drug delivery
… used in MSC delivery in vitro and the nature of cell culture can affect the secretion of cytokines. This is promising for future studies using silk hydrogels to deliver MSCs where excretory profiles should be evaluated more rigorously using 3 independent replicates to validate the findings in …
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The Application of Mesenchymal Stem Cell therapy on Multiple System Atrophy
Since disease progression in multiple system atrophy(MSA) is much faster and no drug treatment consistently benefits MSA patients in the long-term, neuroprotective or regenerative strategies are inevitable in the management of MSA patients. We divided two group, MSC-treated(n＝11) and control …
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Mesenchymal stem cell rescue for bone formation following stereotactic radiotherapy of osteosarcoma
… is pathologic fracture of the irradiated bone. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the capability to differentiate into many cell types including bone. The ability of MSCs to differentiate into bone suggests that they should be investigated as a potential therapy …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
Mesenchymal stem cells (MSCs) are very promising in tissue engineering and regenerative medicine because of their ability to differentiate into different type of cells including bone and cartilage. MSCs differentiation can be modulated using both chemical (i.e. proteins) and physical cues (ie. …
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Complementary Strategies to Promote Mesenchymal Stem Cell Differentiation for Ligament Tissue Engineering
… graft choices for repair of ACL disruptions. The cell-based approach to construct engineered ligament grafts presented herein involves the culture of mesenchymal stem cells (MSC) on biodegradable, fibrous polymeric scaffolds to promote tissue formation. Multipotent MSCs are advantageous because of …
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Investigation of human mesenchymal stem cell genetic characteristics to ensure therapy safety /
Human mesenchymal stem cell (MSC) therapy holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
Mesenchymal stem cells (MSCs) are a promising cell source and widely used in a variety of regenerative applications given their multipotent nature. MSCs are subjected to various types of mechanical forces during tissue development and repair, and it is clear that, along with soluble factors, …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells …
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Biomaterials for the extracellular control of mesenchymal stem cell pro-angiogenic potential
With the prevalence of ischemic heart disease, cell based treatments have emerged as promising therapeutic options to promote angiogenesis. The use of adult mesenchymal stem cells (MSCs), particularly, is an area of active investigation. However, clinical efficacy has proved variable, likely on …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative therapies not possible with conventional small molecule/antibody/ nucleic …
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Elucidating Cause-Effect Relationships between Extracellular Matrix Signaling and Mesenchymal Stem Cell Differentiation
Mesenchymal stem cell (MSC) differentiation is known to be influenced by a range of environmental stimuli. MSC-based bone regeneration strategies would benefit from the identification of scaffold material properties which intrinsically promote osteoblast lineage progression. The aim of this work …
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