Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"mesenchymal stem/stromal cells"”.
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Pain alleviating effects of mesenchymal stem/stromal cells and derived extracellular vesicles in osteoarthritis
… During the search for new therapies for OA, mesenchymal stem cells (MSCs) and derived extracellular vesicles (MSC-EVs) have led to promising therapeutic outcomes such as joint function improvement and pain relief. Whether the observed pain relief effects of MSCs and MSC-EVs originate from the …
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The role of the bone marrow niche and G-CSF in osteochondral repair
… to restore cartilage by delivering bone marrow cells to the defect site. However, the specific identity or contribution of these cells to the repair process is not well understood. Mesenchymal stem/stromal cells are thought to contribute to tissue repair by either progenitor or trophic action. …
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Smart Materials for Cartilage and Bone Tissue Engineering
… cartilage, and the limited number of progenitor cells, it is challenging for regeneration of cartilage defects. Furthermore, because of the distinct structure of cartilage and subchondral bone, stem cell-alone or biomaterial-alone based strategy might not be able to simultaneously fulfil the …
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MODELING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY USING PRIMARY AND PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS
… shows demethylation of D4Z4 using gDNA of blood cells, and Kyba lab has shown that D4Z4 is demethylated in FSHD iPS cells, meaning that any cell type in an FSHD patient could be subject to deregulation by DUX4. DUX4 recruits p300 to induce global changes in histone acetylation, massively …
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MSC DERIVED EV IN REGENERATIVE MEDICINE
… or restoring damaged tissues to healthy states. Mesenchymal stem/stromal cells (MSC) are thought to facilitate tissue repair via either progenitor or secreaome functions. BM-MSC have, in previous work, been investigated as a therapy for OA via either their direct application or through their …
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Comprehensive Proteomic Analysis and Characterization of Human Bone Marrow Mesenchymal Stem/Stromal Derived Extracellular Vesicles
… in therapeutic responses produced by human mesenchymal stromal/stem cells (hMSCs). As the hMSC-EV regenerative capacity is mainly ascribed to the transfer of proteins and RNA composing the EV cargo and to the activity attributed by the protein surface markers, we sought to profile the …
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Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model
… the FAM111B mutation (c.1861T>G) in the multi-systemic fibrosis affecting the South African kindred with POIKTMP. Dermal fibroblasts from two affected siblings and a familial control were reprogrammed into induced pluripotent stem cells (iPSCs) via the Sendai virus vector (SeVdp) packaged with …
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Effect of the Pdgfbʳᵉᵗ mutation on cardiovascular homeostasis
… is a key regulator of the cardiovascular system in development, health, and disease. During angiogenesis PDGFB regulates pericyte migration and proliferation during development and in tissue repair. Pericytes confer vessel stability, maintain vessel integrity, and control vascular tone. In …