Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"mesenchymal cells"”.
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… signaling. Despite such importance, mesenchymal cells are poorly defined morphologically and molecularly. Their signaling regulation is not well understood, lagging their counterparts in the epithelial, endothelial, and immune lineages. Leveraging single-cell RNA-seq, …
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The Role of Mesenchymal Cells in the Regeneration of Salivary Gland Tissue
… expression; here we could identify changes to mesenchymal cell markers such as PDGFRb and CD29 between the PSS and non-PSS tissue. The established immunofluorescent markers could further be used in later experimentations to identify each cell population, particularly when developing cell …
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Examining the roles of resident non-myogenic mesenchymal cell populations in skeletal muscle development and injury
… from both myogenic and their supportive niche cells. The muscular niche is complex. At the cellular level it is composed of a broad number of cell types including: endothelial vessels, nerve and nerve-supporting cells, resident immune populations, and a heterogenous group of non-myogenic …
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… epithelial (keratinocytes) and mesenchyme cells. Attempts to recapitulate the process of hair induction in wounded skin in vitrousing human cells have to date been unsuccessful. The aim of this project is to attempt to elicit the early steps of hair follicle formation (induction) by …
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The mesenchymal regulation of ductal-driven liver regeneration
Liver epithelial cells –hepatocytes and bile duct cells– intermingle with a microenvironment of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become …
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Epigenetic Regulation Controls Intrinsic and Extrinsic Drivers of Gastrointestinal Development
… tube known as the primitive gut tube. Endodermal cells lining the inside of the gut tube differentiate into the functional epithelial units of the gastrointestinal system. Mesodermal cells surround the endodermal layer and eventually develop into an array of mesenchymal cells which support …
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Pocket protein family function in mesenchymal tissue development and tumorigenesis
… and its role in the development of tissues of mesenchymal origin, we sought to understand the consequence of the loss of pRb, and its family member p107, in murine mesenchymal cells. The early lethality of Rb-/- mice hampers the study of many mesenchymal tissues, thus we conditionally deleted …
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The Chemokine Receptor CXCR7 Functions in Endocardial-Derived Cells to Regulate Cardiac Valve Remodeling
… to the rest of the body. Cardiac neural crest cells and endocardial cushions contribute significantly to these remodeling processes. Cardiac valves are fibrous tissues that separate atria from ventricles and ventricles from great vessels, and allow unidirectional blood flow through the heart. …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
… growth factor (CTGF, CCN2) is expressed by mesenchymal cells during development. Mice genetically deficient in CCN2 display severe bone defects and die immediately after birth. The molecular basis of this defect is not known. We've used in vitro models of chondrogenesis to show that CCN2 …
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INVESTIGATIONS ON POTENTIAL OF UMBILICAL CORD LINING STEM CELLS FOR IN VITRO MODELS
Since their discovery, stem cells have been highly regarded for their potential in applications ranging from bench top studies, pharmaceutical applications to cell-based therapy. In our study, the potential of human umbilical cord lining stem cells (UCLSCs) for in vitro models is investigated in …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but retained the hypersensitivity seen in the intact mice. Mesenchymal stem/progenitor cells (osteoprogenitors) demonstrated increased …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic changes in …
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Generation of human inner ear organoids from pluripotent stem cells and an organ-on-chip platform
Inner ear development involves the assembly of cells from a variety of different embryological origins. There is an unmet need for developing a human inner ear model in vitro to mimic both the complex structure and the function of the inner ear outside of the body. Since the human inner ear is …
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Dynamic patterning of maternal mRNAs in the Early C. elegans embryo
… maternal mRNAs pie-1 and nos-2 in non-germline cells. We find that nos-2 mRNA degrades at a constant rate in all somatic lineages, starting approximately 1 cell-cycle after each lineage separated from the germline, consistent with a model in which the germline protects maternal mRNAs from …
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Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… the molecular markers of renal stem/progenitor cells localized in the different niches of ten human preterm kidneys with gestational age ranging from 11 up to 25 weeks. Our data evidence the existence of multiple stem/progenitor pools in different zones of the human developing kidney that are …
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Factors affecting neurogenesis after application of human mesenchymal stem cells in ischemic rat model
… trial of ex vivo culture expanded autologous mesenchymal stem cells (MSCs) in patients with severe ischemic stroke. We proposed that an optimal condition, for either donor or recipient, may exist and enhance the effects of the mesenchymal stem cells in those patients. Thus we evaluated the …
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Regulatory dynamics of the Tbx18 locus in mouse urogenital development
… urogenital sinus epithelium are different, the mesenchymal cells that contribute to these structures are shared. The T-box transcription factor TBX18 is expressed in these mesenchymal cells and beginning at mid-gestation, Tbx18 expressing cells coalesce on the ureter and urogenital sinus …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… irradiated skin with non-irradiated skin. As mesenchymal stem cells isolated from adipose tissue may offer beneficial effects in the regenerative capacity of irradiated tissue, the second part of this study was to compare those cultured from non-irradiated and irradiated breast tissue. …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… of ovarian surface epithelium, granulosa cells, and theca cells. While the sources of ovarian surface epithelium and granulosa cells are known, the embryonic origin(s) of theca stem/progenitor cells have not been definitively identified. Here I show that theca cells derive from two …
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Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
Intestinal Mesenchymal stromal cells (fibroblasts, myofibroblasts and their progenitors) have recently emerged as key players in the interplay between the microbiota and professional immune cells under homeostasis and chronic inflammation. Initiation of microbial interactions with host cells, …
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