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Showing 1 to 2 of 2 for “"mesembrine"”.
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Applications of nitroalkene (4+2); cycloaddition chemistry. The asymmetric synthesis of substituted pyrrolidines and the total synthesis of mesembrine
A general route for the preparation of 2,2-disubstituted 1-nitroalkenes has been developed. Conjugate 1,4-addition of zinc cuprates (RCu(CN)ZnI) to easily obtained (E)-1-nitroalkenes, followed by trapping with phenylselenenyl bromide, and subsequent oxidative elimination afforded the corresponding …
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Potential Natural Product Phosphodiesterase Inhibitors
… unreported in E. lonigfolia was determined. Mesembrine, a known alkaloidal PDE inhibitor, has been a subject of many synthetic studies. A synthetic route was initiated using a diastereoselective Michael addition reaction to generate the target quaternary center.