Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"mesangial cell"”.
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T-type calcium channels and human mesangial cell proliferation
Aberrant proliferation of human mesangial cells (MC) is a critical step in the pathogenesis of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression …
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Identifizierung und funktionelle Charakterisierung des Spleißfaktors SRp30c als Interaktionspartner des Y-box-Proteins-1 (YB-1)
… performing a two-hybrid screen against a human mesangial cell cDNA library. Co-immunoprecipitation studies confirm a direct interaction of tagged proteins YB-1 and SRp30c in the absence of RNA via two independent protein domains of YB-1. A high affinity interaction is conferred through the …
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Subzelluläre Lokalisation des Y-box-Proteins-1 (YB-1) in Mesangialzellen und Charakterisierung der dafür verantwortlichen Proteindomänen
… day YB-1 localizes to the perinuclear region of cells within all glomeruli . In the course of the disease the strongest cytoplasmic YB-1 signal coincided with the peak mesangial cell activation/proliferation between days 4 and 6 and was detected in a mesangial distribution pattern. With …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement membrane (anti-GBM) glomerulonephritis and Systemic Lupus Erythematosus (SLE). SV40-transformed mouse mesangial cells (MES13) were cultured with pure CLA isomers (c9,t11 or …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… expression, may contribute to aberrant immune cell function in SLE. miRNAs are small, noncoding RNAs that bind to the 3’ untranslated region of target mRNAs resulting in post-transcriptional gene modulation. IL-6, an inflammatory cytokine overproduced by mesangial cells in SLE, contains a …
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Identifizierung und Kartierung von nukleären Import- und Exportsignalmotiven innerhalb des Y-box-bindenden Proteins-1 (YB-1)
… interactions. Shuttel between the cell nucleus and cytoplasm is essential for YB-1 functionality. In immortalized and proliferationg cells YB-1 is localised in cytoplasm. After stimulation with cytotoxic agents, under hyperthermia or ultraviolet light YB-1 translocates to the …
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Interaktion von nativem und oxidiertem Lp(a) mit menschlichen Mesangialzellen und Matrix
… von nativem und oxidiertem LDL in menschlichen Mesangialzellen und an der mesangialen Matrix wurden untersucht und beschrieben. Die Versuche wurden auch mit nativem und oxidiertem Lp(a) durchgeführt. Versuche zur Proliferation menschlicher Mesangialzellen unter Einfluss unterschiedlicher …