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Showing 1 to 6 of 6 for “"mercapturic acid"”.
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The urinary excretion of mercapturic acids in free-living adult males
… glutathione conjugation, the level of urinary mercapturic acid excreted by a free-living male population and the effect of external environmental and genetic factors, such as consumption of vegetables, fruits, and meat, charbroiled food intake, tobacco, alcohol, caffeinated coffee, and …
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The dynamic interplay between DNA damage and metabolism : the metabolic fate and transport of DNA lesions and novel DNA damage derived from intermediary metabolism
… three major metabolites: thymine propenoic acid and two mercapturic acid derivatives, which accounted for ~6% of the injected dose. An additional four metabolites, including conjugates with GSH, cysteinylglycine and cysteine, were observed in bile and accounted for ~22% of the dose. One of …
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Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… SBMA and o-MBMA in human urine. Urinary S-phenylmercapturic acid (SPMA) is a biomarker proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) for assessing occupational exposure to benzene (Biological Exposure Index of 25 microg/g creatinine). Urinary …
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Determination of Relative Cancer Preventative Effects of Cruciferous Vegetables
… 30-fold more effective than pure SF. Urinary SF-mercapturic acid (SF-M) was similar in rats receiving dietary hydrolyzed broccoli (1.6 mumol SF/rat/day), freeze-dried broccoli (22.0 mumol GP/rat/day) and pure SF (50 mumol/rat/day) alone or added to broccoli. Also, urinary SF-M correlated with QR …
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Mercaptursäure und Nukleosidaddukt im Harn als Biomarker in 1-Hydroxymethylpyren-exponierten Ratten
1-Methylpyren (MP) ist hepatokanzerogen in neugeborenen männlichen Mäusen. Durch Hydroxylierung an der benzylischen Stelle und anschließende Sulfonierung wird MP zu DNA-reaktivem 1-Sulfooxymethylpyren (SMP) aktiviert. In der Ratte führt die Exposition des benzylischen Alkohols, 1-Hydroxymethylpyren …
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Metabolismus von alkylierten polyzyklischen aromatischen Kohlenwasserstoffen : Einfluss der Struktur auf benzylische Hydroxylierung und Sulfonierung in vitro und Modulation des Metabolismus in vivo
Die Toxizität und Kanzerogenität von rein aromatischen polyzyklischen aromatischen Kohlenwasserstoffen (PAK) ist seit Jahrzehnten bekannt und umfassend erforscht. Die alkylierten PAK (alkPAK) besitzen jedoch aufgrund ihrer Alkylgruppe eine weitere Möglichkeit zur Bioaktivierung und müssen daher …