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Showing 1 to 15 of 15 for “"menaquinone"”.
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Development of novel approaches for industrial fermentation of menaquinone-7
… and therefore must be supplied in the diet. Menaquinones (MK) together with phylloquinone (PK) fall under the common name ‘vitamin K’. Recent studies show that dietary intake of menaquinones results in more health benefits than phylloquinone. Menaquinone-7 (MK-7) plays an important role in …
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Design and Synthesis of Inhibitors of Mycobacterium tuberculosis Menaquinone D (Mtb MenD) as Potential Therapeutics for Tuberculosis (Tb)
Menaquinone (MQ) is a lipid-soluble electron carrier central to mitochondrial energy metabolism in Mycobacterium tuberculosis (Mtb) and other Gram-positive pathogenic bacteria. Menaquinone biosynthesis presents a potential target for therapeutic intervention, as it is not produced in humans. In …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… of action, and inhibition. HepPPS is involved in menaquinone biosynthesis, a key electron transporter in many pathogens. It is a heterodimer consisting of a catalytic subunit and a regulatory subunit. High concentrations of substrates (FPP and IPP) inhibit the enzyme, which is also inhibited by …
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Fermentation of vitamin K2 (menaquinone-7): Development of an optimal fermentation process to selectively enhance the production of the biologically significant all-trans isomer
… namely vitamin K1 (phylloquinone), vitamin K2 (menaquinones), and vitamin K3 (menadione), which share a common 2-methyl-1,4-naphthoquinone moiety but differ in the structure of a lateral isoprenoid chain at the 3-position. Despite their structural similarities, all K vitamers have different …
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Biochemical characterization of a-type heme-copper oxidases in escherichia coli, bacillus subtilis and thermus thermophilus
… a close homolog to cytochrome bo3 that uses menaquinone instead of ubiquinone. Recently, in vivo experiments have demonstrated that cytochrome bo3 could also use menaquinol as substrate. Therefore, with 14N and 15N labeling, the interaction between menaquinone semiquinone radical and quinone …
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Characterization of Ortho-Succinylbenzoate Synthase (Osbs): A Study of Mechanism, Proficiency and Evolutionary Diversity
… catalyzes a dehydration reaction in the menaquinone biosynthetic pathway. Menaquinone is an electron acceptor that is utilized in bacteria, archaebacteria and red green algae. OSBSs from over 70 organisms have been identified and their pairwise sequence homology is often as low as 14%. …
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The Evolution of Enzymatic Activity in the Crotonase Superfamily: The Mechanism of the Reaction Catalyzed by 2-Ketocyclohexanecarboxyl-Coa Hydrolase
… a forward Dieckmann reaction in microbial menaquinone biosynthesis.
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Structural and biochemical studies on enzymes involved in natural product biosynthesis and cellular respiration
… We carried out structural studies on the aa3-menaquinone oxidase, which has high sequence similarity with ubiquinone oxidase from E. coli. We believe structural information on the aa3 can elucidate the mystery of the quinone/menaquinone binding site, which is critical for the q cycle in the …
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Mutagenesis and Spectroscopic Studies on Cytochrome Bd Quinol Oxidase of Escherichia Coli
… the enzyme was able to bind both ubiquinone and menaquinone, and identified an acidic residue, either aspartate or glutamate, as being involved in the binding of ubiquinol/menaquinol. The NMR study was also the first time that high field proton NMR was successfully applied to such a large …
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Electron Transfer in the Reaction Center From Rhodopseudomonas Viridis (Photosynthesis, Bioenergetics, Bacteria)
… The primary quinone, Q(,A), was identified as menaquinone and the secondary quinone, Q(,B), as a ubiquinone. The forward electron transfer equilibrium, from Q(,A) to Q(,B), was found to be driven by a large enthalpy decrease which compensated a decrease in entropy. This electron transfer was …
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Insights Into The Reactivation, Regulation and Essentiality of Oxidative Protein Folding Pathways In Actinobacteria
… subunits, and <em>ubiE</em>, a menaquinone C-methyltransferase encoding-gene, confirmed defects in reactivation of MdbA. Our findings indicate these ETC components are biochemically linked to pilus assembly via oxidative protein folding.</p> <p>Because deletion of <em>mdbA …
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Quinol activity of cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis characterized by biochemical and EPR methods
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01
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Screening environmental actinobacteria for antimycobacterial antibiotics and characterisation of Kribbella stellenboschensis sp. nov
… of the genus Kribbella: i) MK9(H4) as the major menaquinone; ii) LL-diaminopimelic acid as the diagnostic diamino acid; iii) anteiso-C15:0 and iso-C16:0 as the major fatty acids (>10%); and iv) phosphatidylcholine in the polar lipid profile.
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Characterisation and applications of bacteriocinogenic Isolates from the deep-sea fish microbiome
… range of growth conditions and the presence of menaquinone 5 as a respiratory quinone, Planococcus notacanthi was deemed a novel species, with APC 4016 as the type strain. We also explored the application of these deep-sea isolates and their DNA as controls for determining relative and/or …
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Biochemie a patobiochemie fylochinonu a menachinonů
SOUHRN Vitamin K patří mezi poslední z lipofilních vitaminů, který není v klinických laboratořích rutinně stanovován. Vitamin K působí jako důležitý kofaktor posttranslační γ-karboxylace glutamové kyseliny u vitamin K dependentních proteinů (např. osteokalcin, koagulační faktory II, VII, IX, X). …