Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"memory subsets"”.
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
T lymphocytes comprise diverse subsets which differ in phenotype, function and maturation level. Among them, T memory stem cells (TSCM) represent the more developmentally immature subpopulation of the memory pool, endowed with longevity, self-renewing capacity and multipotency, other than recall …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… latent reservoir is established mainly in CD4+ T memory ad naïve cells early during infection under conditions that are still not well defined. CD4+ T memory lymphocytes are highly heterogeneous and comprise both effector and long-lived subsets. This study aimed to analyze HIV latency …
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Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy
… comparing their cytokine secretion ability and memory differentiation profiles in response to Mycobacterium tuberculosis and cytomegalovirus in HIV-infected (n=15; pre- and post-ART), compared to uninfected (n=9) individuals. Finally, Chapter 4 examined changes in B cell activation and memory …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
… activation of CD4+ and CD8+ effector/effector memory and central memory subsets, with increased production of interferon gamma, perforin and granzyme B that exhibit cytolytic activities against the infected cells. Further, nanovaccine immunized pregnant mice exhibited effective control of the …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… has been shown to be critical to maintain T cell memory required for persistence and sustained effector function. In this thesis, I investigate the expression of TCF7 and the less studied TCF7L2, both Wnt transcription factors of the TCF/LEF family, in different immune subsets. I focus on the …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity</strong></p> <p>Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by the expression of a chimeric antigen receptor (CAR). …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of …
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Investigating SARS-CoV-2 immune responses in children
… during SARS-CoV-2 infec<on. When comparing the memory differen<a<on profile of SARS-CoV-2- specific T cells, we found that children and mothers had early differen<ated (ED) memory profile as the dominant memory subset of SARS-CoV-2-specific T cells, which is associated with long-term immunity. …