Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"memory impairments"”.
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Working memory impairments in children and adolescents after traumatic brain injury
… exists on the extent of impairment of working memory (WM), specifically central executive (CE) functioning after TBI, and whether such an impairment immediately post injury lessens over time. The present study examined the WM functioning on 38 TBI children and adolescents (24 mild TBI and 14 …
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Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens
… system that subserves efficient memory-based foraging behavior. These lesions impaired performance on the spatial win-shift but not the cued win-stay task. Pre-training lesions on the spatial win-shift task did not affect foraging for four pellets during either the training or …
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Role of cortisol in social and memory impairments in individuals with velocardiofacial syndrome (VCFS)
… that cortisol has on the social and cognitive impairments observed in children with VCFS. To this end, 11 children with confirmed VCFS were assessed for baseline cortisol levels and received neuropsychological testing that assessed attention, memory, language, and social functioning. These …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… underlying cannabinoid impairment of fear memory is not clear. This study investigated the effects of the synthetic cannabinoid HU210 and the endocannabinoid hydrolysis inhibitor JZL 195 on fear memory following contextual fear conditioning (CFC; an animal model of fear). The long-term …
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Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine
Memory impairments accompany aging and can range in severity from mild deficits during healthy aging to debilitating conditions such as Alzheimer’s disease. The causes of these impairments are generally viewed in terms of anatomical, chemical, and physiological changes within the brain. However, …
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A Mobile Augmented Memory Aid for people with Traumatic Brain Injury
… has increased to 790 per 100,000 population. Memory impairment is the most common symptom and affects most TBI survivors. Memory impairments resulting from TBI take many forms depending on the nature of the injury. Existing work to use technology to help with memory problems focuses …
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EEG Features of Working Memory Impairment in Alzheimer’s Dementia and Mild Cognitive Impairment
The presence of working memory impairments in individuals with Alzheimer’s Dementia (AD) or Mild Cognitive Impairment (MCI) is well-accepted; however, the neurophysiological mechanisms contributing to these impairments have not been fully elucidated. Research has reliably shown that oscillatory …
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Protein Synthesis Inhibitors Impair Memory by Disrupting Release of Neurotransmitters Important for Memory Modulation
… that de novo protein synthesis is necessary for memory consolidation is widely accepted, yet supported by evidence based primarily on results using protein synthesis inhibitors. Injection of a protein synthesis inhibitor near the time of training often spares memory of the training experience for …
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The role of heterozygous lysosomal storage disorder alleles as risk factors for dementia
… mice. AppNL-G-F/NL-G-F mice did not have memory impairments detectable in a Y-maze, novel object recognition test or Morris water maze at six-months. They did, however, exhibit reduced open field activity and lysosomal network disruptions. Lysosome-associated membrane protein 1 and …
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Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons
<p>Chemotherapeutic agents impair memory in humans as well as in animal models. Such memory impairments can be persistent, lasting years after exposure to chemotherapy. Doxorubicin (DOX), a common chemotherapeutic agent, has been associated with memory impairments in humans and induces memory …
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The role of ras signaling associative learning and memory in Drosophila
… the role of Ras in associative learning and memory in Drosophila. Flies carrying hypomorphic ras mutations were impaired in memory, with normal learning performance. The severity of the memory impairment correlated with molecular lesions in the ras gene. Studies on synaptic morphology at …
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Working Memory in Posttraumatic Stress Disorder: Trauma Cue Reactivity
… patients frequently present with working memory impairments. Working memory training has been established as an effective intervention to reduce posttraumatic stress symptoms. Working memory is associated with posttraumatic stress disorder in that it is commonly impaired in patients and …
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Reinterpreting selective impairments in memory: computational and empirical simulations of dissociations in amnesia
By a dominant account, memory is composed of multiple storage systems, each operating according to unique principles. By an alternative account, memory is a single storage system and operates according to a single set of principles. Selective memory impairments in amnesia serve as the primary …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… (CNS) complications, including learning and memory deficits and seizure. MPS IIIA patients have short life expectancies and there currently is no cure for the disease. This thesis work was aimed at identifying an early neurological phenotype in the mouse model of MPS IIIA. The data will aid …
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PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… synaptic plasticity, which underlies long-term memory, depends on new gene transcription, new protein synthesis, as well as proteolytic degradation of regulatory proteins by the ubiquitin-proteasome pathway (UPP). To study the molecular mechanisms of learning and memory, we use the late phase of …
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Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models
… but often overlooked fact that successful memory involves more than just remembering events over a period of time, but also differentiating between similar memories. Through a series of experiments this dissertation adds support to the literature that the dentate gyrus (DG) subregion of the …
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Response Guided Errorless Learning with Normal Elderly
… than trial and error learning for people with memory impairments, its use with normal individuals has received limited attention. The questions of interest were whether errorless training of the perceptual motor task was more effective for improving and retaining accuracy; and whether both …
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The Impact of Pomegranate on Memory Dysfunction after Cardiac Surgery
… in reducing cognitive declines, specifically memory, after cardiac surgery. Methods: The sample consisted of 10 patients, who had undergone elective, on-pump, normothermic cardiac surgery (CABG and/or valve surgery). Participants in the treatment group were given two pomegranate (PomX) …
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Persistent (>6 months) Neuropsychiatric symptoms in a cohort of SARS- CoV-2 PCR positive patients in Cape Town, South Africa
… participants showed evidence of cognitive and/or memory impairments. There were no significant associations between neuropsychiatric outcomes and illness severity, systemic inflammation, cardiovascular and renin-angiotensin-system (RAS) biomarkers. Conclusion : The high prevalence of persistent …
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