Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"memory CD8+ T cells"”.
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The Role of Map Kinases On The Functional Heterogeneity of Human Cd8+ T Cell Maturation Subsets
… focused on naïve (CD45RA+CD27+) and early stage memory (CD45RA-CD27+) CD8+ T cells, late memory CD8+ T cells (CD45RA+CD27) have received less interest because this subset of T cells is generally recognized as effectors, which produce IFNγ (but no IL-2) and perforin. However, multiple studies …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
CD8+ T cells are the main adaptive immune system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… latency and autoimmune disease on CD8+ T cell differentiation. To examine how memory CD8+ T cells generated during latency differ from those primed in acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and compared their …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
<p>The maintenance and generation of memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
<p>The maintenance and generation of memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells though induction of IL-15 and IL-15Rα. We found that the frequencies of IL-15Rα were …
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Multigenic Regulation of the Shutdown of Immune Responses
… generating increased numbers of antigen-specific memory CD8+ T cells. During acute viral infection, large numbers of effector CD8+ T cells are generated. Following viral clearance, the majority of these cells undergo apoptosis during the contraction phase, while the surviving cells differentiate …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… rejection, we hypothesized that human cancer cells genetically modified to express the alphaGal epitope could provide a new anti-cancer vaccine. This hypothesis was previously studied using the alpha1,3-galactosyltransferase knockout (alphaGT KO) mouse model and B16 melanoma cells genetically …
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
… controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. However, generating memory CTLs remains a major challenge for conventional vector-based, prime-boost vaccinations. Thus, it is …
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The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection
… role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent of CD4 T cells, but it is not clear why some primary, pathogen-specific CD8 T cell …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… to determine stimulatory activity of mSOT201 for CD8+ and CD4+ T cells both in vitro and in vivo, and to assess the formation and phenotype of long-lived memory CD8+ T cells following antigen-priming and stimulation with mSOT201. Finally, we evaluated antitumor activity of mSOT201 in selected …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of …
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A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… responsible for homeostatic proliferation of T cells in lymphopenic hosts, as well as maintenance of naïve and memory CD8+ T cells in the periphery. A number of regulators of IL-7R[alpha][alpha] have been identified, but the complex processes underlying fine control of IL-7R[alpha][alpha] …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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The Role of CCR7 and Its Ligands in a Behcet’s Disease Mouse Model
… of CCR7 ligand DNA induces the expression of memory T cells. It was also reported that expression of CCL21 in Behcet’s Disease (BD) patients was low. In this study, we investigated the expression of CCR7 and its ligands in BD mice, and also observed the changes of memory T cells and BD …
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The roles of Cabin1 and Left1 in T cell development
… changes in immunoglobulin class switching as B cells from mutant mice switched to IgG 1 at the same frequency as wildtype B cells in vitro in the presence of IL-4. However, in response to anti-CD3 stimulation, mutant T cells expressed significantly higher levels of IL-2, IL-4, IL-9, IL-13, and …
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
… This novel antigenic sequence, absent in healthy cells, represents an attractive target for tumor-specific immunotherapy with minimal side effects. To evaluate the neoantigenic potential of CD74-NRG1, 36 peptides (9, 10, and 11 amino acids) derived from the fusion junction and wild-type sequences …
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
… of proteins expressed on human natural killer cells and a subset of T cells. Several inhibitory KIRs have been shown to recognise MHC class I molecules (predominantly HLA-C), with their engagement preventing target cell lysis. The ligand(s) and function(s) of activating KIRs, however, are less …
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