Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"memory B-cell"”.
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
… life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn Errors of Immunity (IEI) shed light on the molecular and …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… altering the same immune-mediated pathways in T cells. I found evidence that showed the causal role of 46 genes in predisposing to the three disease groups; eight of these genes are already targeted by treatments in autoimmunity and could be exploited for drug repurposing. Supporting preclinical …
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Genetic Subclones Identify Phenotypic Variation in Diffuse Large B-Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma. Many efforts have characterised DLBCL subtypes that account for some of the heterogeneity in clinical outcome following standard therapy. However, not much is known regarding intratumoural heterogeneity. Case …
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SARS-CoV-2 Variants and Vaccines
… entry efficiency of the virus into the host cells. These novel variants included B.1.1.7 (alpha), B.1.351 (beta), P1 (gamma), B.1.617.1 (kappa), B.1.617.2 (delta), and B.1.1.529 (omicron). These variants had mutations in the receptor binding domain (RBD) of the spike glycoprotein which …
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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity
… To characterize the broadly neutralizing memory antibody responses to HIV we cloned 1078 antibodies from HIV envelope binding memory B cells from eight HIV infected patients with broadly neutralizing antibodies. We found that in these patients, the B cell memory response to gp140 is …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… hypogammaglobulinemia. A number of defects of T cell function and deficits in the memory B cell pool have been identified, but the underlying cause for this defect remains unknown. In vitro stimulation experiments with CVID peripheral blood B cells (CD19+) showed, that CVID B cells could secrete …
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Development of microanalysis tools for characterization of the humoral response to infections diseases
… produced by a subset of lymphocytes (B cells) in the immune system for protection against pathogenic species. These homodimers of heterodimers form highly specific interactions with their cognate antigens and hence have become very important for the development of prophylactic or …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… PAMPs and induces vigorous anti-WNV T and B cell responses. However, the innate mechanisms that link pattern recognition and development of vigorous antigen-specific T and B cell responses are not completely understood. Moreover, the roles of individual PRR signaling pathways in shaping T and …
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Phosphatidylserine-Based Nanoparticles For Tolerance Induction Towards Therapeutic Proteins
… abundant negatively charged phospholipid in the cell membrane. Despite comprising 12% of total phospholipid and being restricted primarily in the inner leaflet of the membrane bilayer, the consequences of PS externalization to the outer leaflet is biologically significant, especially in …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way their B cell receptors bind antigen and generate antibodies that provide protection against infections. Due to their de novo formation and less stringent …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
… In addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sensitive detection reagent. We sought to improve the binding and activation of B …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… vaccination against SARS-CoV-2 were assessed. Cellular immune responses, driven by cytotoxic CD8+ T cells, appeared to be robust and well maintained across disease states. Impairment of the humoral, antibody and memory B cell, responses to vaccination was seen in those with elevated levels of …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… partially impair IFN-γ production by diverse T cell subsets through distinct mechanisms such as development, exhaustion, and epigenetic imprinting.Thus, the first part of my graduate research demonstrates that even partial impairment of T-cell IFN-γ production can underlie TB in young humans. …
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Clonal Studies of Human B Cells
… and adaptive immunity. The diverse roles of B cells can be attributed to the various and distinct types of B cells as determined by their origin, developmental stage, antigen specificity, and function.</p><p>Evidence suggests that human innate-like B cells (i.e., marginal zone and/or B1-like B …
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Untersuchungen über die antigenspezifische Immunität nach Diphtherie- und Tetanus-Schutzimpfung mit dem B-Zell-ELISPOT-Test
… Auffrischimpfung auf die antigenspezifischen Memory-B-Zellen und die Antikörper-Titer untersucht. Dazu wurden antigenspezifische Antitoxin-Spiegel mittels ELISA und im Neutralisationstest sowie spezifische Memory-B-Zellen mit dem B-Zell-ELISPOT-Test bei 13 Probanden bestimmt. Es zeigte sich, …