Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"memory B cells"”.
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Interplay between Extra-Germinal Center expansion of memory B cells and affinity maturation during the humoral recall response
… requires a better understanding of how immune memory is generated and recalled. Upon vaccination or infection, B cells and the antibodies they secrete, undergo a Darwinian evolutionary process in the Germinal Center (GC) to generate tailored memory and antibodies. Memory B cells generated in …
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Immunologic Memory to Polysaccharide Antigens
<p>Immunologic memory is the ability of the immune system to generate an enhanced antibody response against previously encountered antigens. The clonal selection theory of acquired immunity attributes immunologic memory to the formation of an expanded compartment of quiescent antigen-specific …
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Changes in peripheral B cell subsets under immunosuppressive therapy
… may progress to chronic autoimmune diseases. B cells play an important role in the pathogenesis of autoimmune diseases and influence autoimmunity through multiple pathways. With the availability of informative B cell surface markers it is now possible to identify within the circulating B cell …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
… disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn Errors of Immunity (IEI) shed light on the molecular and cellular requirements for …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… is limited. An example of this is transitional B cells. Although transitional B cells are known to exist in humans, detailed characterisation of these cells has not been performed. Human transitional B cells can be identified as CD24++CD38++CD10+ cells and attempts have been made to segregate them …
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Clonal Studies of Human B Cells
… and adaptive immunity. The diverse roles of B cells can be attributed to the various and distinct types of B cells as determined by their origin, developmental stage, antigen specificity, and function.</p><p>Evidence suggests that human innate-like B cells (i.e., marginal zone and/or B1-like B …
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The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models
… and evaluating the phenotypes and functions of memory cell development in immunized mice. My results suggest that both VLP and VSV-vectored HIV vaccinations robustly induce humoral responses by eliciting HIV-specific memory B cells, while VSV-vectored HIV vaccination activates cellular responses …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… defects of T cell function and deficits in the memory B cell pool have been identified, but the underlying cause for this defect remains unknown. In vitro stimulation experiments with CVID peripheral blood B cells (CD19+) showed, that CVID B cells could secrete IgM, but no or only few IgG. …
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
An increasing body of work shows that T-bet+ B cells play important roles in immune responses to infections a well as in autoimmune diseases. These studies investigate the kinetics, tissue distribution, and functions of T-bet+ B cells in a murine influenza infection model. Both T-bet+ and T-bet- …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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The role of antibodies in tuberculosis
… Fourthly, I tested whether unswitched memory B cells, and specifically the marginal zone B cells (MZB) subset, are impacted by ATB. MZB respond to capsular pathogens and could thus recognize the M.tb cell wall. MZB are found to be depleted in ATB but are not enriched at the site of …
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Quantification and Molecular Characterization of Anti-citrulline Antibodies in Rheumatoid Arthritis
… arrays, to isolate antibodies from stimulated memory B cells of RA patients. In conjunction with single-cell RT-PCR amplification this technique is employed to perform molecular characterization of ACPA antibodies.
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… altering the same immune-mediated pathways in T cells. I found evidence that showed the causal role of 46 genes in predisposing to the three disease groups; eight of these genes are already targeted by treatments in autoimmunity and could be exploited for drug repurposing. Supporting preclinical …
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Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation
… In addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sensitive detection reagent. We sought to improve the binding and activation of B …
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Neutralizing antibody responses in HIV dual infection: lessons for vaccine design
… whether superinfection re-engaged cross-reactive memory B cells, promoting the development of cross-neutralizing antibodies. By comparing the breadth of the neutralizing antibody response in superinfected individuals to those that typically develop in singly infected individuals, we showed that …
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Modelling the affinity maturation of B lymphocytes in the germinal centre
… of the germinal centre that enables the B cells to move and interact with other cells inside the germinal centre. This allows the modelling of the affinity maturation of the B cells to produce high affinity antibodies. The model was validated against the available published population …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… establishes a harmless infection in human memory B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines derived from GC B cells are a …
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Single Cell Analysis of B Cell Responses to Malaria
… to produce affinity matured long lived plasma cells (LLPCS) and memory B cells (MBCS) is crucial for the formation of life-long immune memory. However, there is still relative controversy over what factors influences the generation of these different B cell fates. Utilising high throughput …
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Single Cell Analysis of B Cell Responses to Malaria
… to produce affinity matured long lived plasma cells (LLPCS) and memory B cells (MBCS) is crucial for the formation of life-long immune memory. However, there is still relative controversy over what factors influences the generation of these different B cell fates. Utilising high throughput …
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