Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"membrane transporter"”.
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Using mutagenesis and molecular cloning techniques to identify key residues within the molecular recognition site of the Glucuronide Membrane Transporter (GusB).
The glucuronide transport membrane protein (GusB) encoded by the gusB gene is essential for the survival of Escherichia Coli (E. coli) residing in the gut of vertebrate species. This gene, along with four others located on the GUS operon, allows E. coli to scavenge carbon from detoxification …
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The occurence, distribution and frequency of membrane transporter resistance alleles in <i>Plasmodium falciparum</i> and their association with response and resistance to Arteminisin based combination therapy (ART) in Northern Nigeria
… the occurrence and distribution frequency of membrane transporter resistance alleles, in two different <i>P. falciparum</i> proteins, that possibly confer resistance to Artemisinin, and statistically analyse whether any of these resistance alleles; show a significant association with the …
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Characterisation of the role of VPS33B in Vesicular trafficking in polarised Epithelial cells.
… with abnormal localisation of some polarised membrane transporter proteins. Distinct apical and basolateral poles are essential for epithelial function and organ development but the molecular pathways determining the biogenesis of polarised membranes are not fully characterised. Mutations in …
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
… TbpA and TbpB. TbpA is a TonB-dependent, outer membrane transporter and TbpB is a bilobed, surface exposed lipoprotein. TbpB can distinguish between apo- and holo-transferrin which is involved in increasing the efficiency of iron uptake through the Tbps. It is anchored in the outer leaflet of …
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Haem and xenosiderophore mediated iron acquisition by sinorhizobium meliloti and pseudomonas aeruginosa
The bacterial cell membrane is the principal barrier for the acquisition of essential nutrients such as iron. Although critical to the survival of bacteria, iron is extremely limited in the environment due to the formation of insoluble hydroxides at physiological pH. To surmount these obstacles …
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… with the tumour grade, expression of MCT1, the membrane transporter taking up pyruvate, and total LDH, catalysing pyruvate-to-lactate conversion. Improved image analysis tools, physiological and novel metabolic MRI can support precision oncology through better patient stratification and early …
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The Characterization of the Fucose Sensing Kinase (FUSK) and the Fucose Sensing Response Regulator (FUSR) and Their Role in Virulence Regulation in Enterohemorrhagic Escherichia Coli O157:H7
… indirectly, through regulation of the predicted membrane transporter Z0461, involved in optimal fucose uptake. Gut commensal Bacteroides thetaiomicron (B.theta) degrades mucin, releasing free monosaccharides, including fucose, into the gut lumen. Co-culture of B.theta and EHEC on mucin indicates …
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The Molecular Mechanism Of The Gwas Association Of The Slc22a1 Locus With Metabolic Traits
SLC22A1 is a hepatic plasma membrane transporter that transports a wide array of endogenous and xenobiotic molecules; however its impact on the physiology has been largely unexplored. Genome-wide association studies (GWASs) have revealed novel associations at the SLC22A1 locus for plasma …
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Investigating the function of the multidrug transporter ABCG2
ABCG2 is a polyspecific membrane transporter of the ATP-binding cassette (ABC) superfamily, which is responsible for the efflux of a wide array of structurally unrelated molecules from mammalian cells. Physiologically, the protein is thought to serve a protective role; ABCG2 is expressed in certain …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… Further investigation identified the membrane transporter SLC6a8 as an important effector of the CKB pathway and also a promoter of colon cancer metastasis. The final part of this study reveals miR-483-5p, miR-551a, CKB and SLC6a8 to be clinically relevant across multiple patient …
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
… role, function, and mechanism of Plasmodium membrane transporter proteins.<br/><br/>Bioinformatic studies of the most virulent human malaria parasite, Plasmodium falciparum, genome identified a putative homologue of the Vacuolar Iron Transporter (VIT) family, subsequently named PfVIT. This …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… and suggest that megalin, a saturable endocytic membrane transporter, may be largely responsible for aminoglycoside accumulation. Despite the overwhelming evidence for a significant role of megalin in aminoglycoside accumulation, the complete mechanism of uptake has not been fully elucidated, nor …
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Cloning and characterisation of the HMA3 gene and its promoter from Arabidopsis halleri (L.) O'Kane and Al'Shehbaz and Arabidopsis thaliana (L.) Heynhold
… to the P-type IB ATPase family of integral membrane transporter proteins that transport transition metals. In contrast to the low AtHMA3 transcript levels in A. thaliana, the gene was found to be constitutively highly expressed across different Zn treatments in A. halleri, especially in …
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
… uptake of the queuine base across the plasma membrane; incorporation of this base into cytoplasmic tRNA; and salvage of the base from products of normal tRNA degradation. The queuine membrane transporter and incorporation enzyme are activated via phosphorylation by protein kinase C and …
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Atomistic insights into the structure, dynamics, and regulation of integral membrane proteins
… to static structural methods alone. Cell membranes and their associated proteins play essential roles in fundamental cellular processes and are implicated in numerous diseases. Understanding the dynamics and regulation of membrane proteins is therefore critical for both basic biology and …
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MARKOV STATE MODELS AND THEIR APPLICATIONS IN PROTEIN FOLDING SIMULATION, SMALL MOLECULE DESIGN, AND MEMBRANE PROTEIN MODELING
This dissertation is focused on the application of Markov State Models on protein folding and designing of small drug-like molecules, as well as application of computational tools on the study of biological processes. The central focus of protein folding is to understand how proteins obtain their …
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Molecular mechanisms of neurotransmitter transport in neurons
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Insights into dynamics of membrane transporters from computational techniques
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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Mitigating oxidative stress in childhood cerebral adrenoleukodystrophy -an investigation of N-acetylcysteine pharmacology
… in the ABCD1 gene, which encodes the peroxisomal membrane transporter for transporting very long chain fatty acids (VLCFAs) into peroxisomes for degradation. As a result, VLCFAs accumulate in the plasma and tissues of ALD patients. Elevated VLCFAs along with ABCD1 gene mutations are used for the …
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