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Showing 1 to 10 of 10 for “"membrane transport proteins"”.
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Computational study of the structure and function of membrane transport proteins
Transport of the nutrients across the cell membrane is regulated by membrane transport proteins which selectively and efficiently transports materials across the membrane. In the present work I focus on the family of membrane transporters the so called sugar porters in both their mammalian and …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
Membrane transport proteins (MTPs) transfer nutrients, metabolic products and inorganic ions across membranes. Many MTPs are essential for Plasmodium blood infection and gain importance as candidate drug targets in malaria therapy, whereas the physiological functions of many MTPs still remain …
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Towards functional assignment of Plasmodium membrane transport proteins: an experimental genetics study on four diverse proteins
Membrane transport proteins (MTPs) transfer nutrients, metabolic products and inorganic ions across membranes. Many MTPs are essential for Plasmodium blood infection and gain importance as candidate drug targets in malaria therapy, whereas the physiological functions of many MTPs still remain …
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Characterization of FhuA 104/149C: a Double Cysteine FhuA Mutant with Normal Binding and Diminished Transport
… cells actively uptake these complexes via outer membrane-transport proteins such as FhuA in <em>Escherichia coli</em>. Structural analysis of receptors revealed a conserved β-barrel occluded by an N-terminal plug domain. The cell membrane TonB/ExbB/ExbD complex presumably supplies energy via …
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Structure-function studies of human SLC36 amino acid transporters
… Linked Carrier family 36 (SLC36) of integral membrane transport proteins has four members which are also known as the human Proton coupled Amino acid Transporters (hPATs).This is due to hPATs 1 and 2 having been functionally characterized as proton coupled transporters that bring about a 1:1 …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… "permeases" responsible for cholesterol transport across the intestinal brush border. In addition, members of the nuclear receptor superfamily of ligand-activated transcription factors are known to modulate expression of genes involved in cholesterol and bile acid homeostasis, and …
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Structural and functional investigation of the organic anion transporting polypeptide 1B1 (OATP1B1)
Membrane transport proteins are the gatekeepers of the cell membrane, transporting compounds in and out of the cell. The organic anion transporting polypeptides (OATPs) are a family of transport proteins expressed in a variety of tissues, including absorptive I excretory cells of the liver and …
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Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
… engages with HH ligand. DISP1 contains 12 transmembrane helices and two extracellular domains (ECDs) in an open state, unlike its structural homologues PTCH1 and NPC1, whose extracellular/luminal domains adopt a closed state. Wnt signaling is essential for embryonic development and adult tissue …