Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"membrane trafficking"”.
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Membrane trafficking of ATP-sensitive potassium channels
… regulated. The number of channels in the plasma membrane could be regulated in two ways; firstly by regulating the overall population of channels within the cells by increasing/decreasing the rates of channel synthesis or degradation, and secondly by regulating the insertion and removal of …
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Rab-domain dynamics in endocytic membrane trafficking
… cells depend on cargo uptake into the endocytic membrane system, which comprises a functionally interconnected network of endosomal compartments. The establishment and maintenance of such diverse compartments in face of the high rates of exchange between them, poses a major challenge for …
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Profilin II : novel functions in membrane trafficking
Profilin II - Novel functions in membrane-trafficking Ralph Gareus - EMBL Mouse Biology Programme, Monterotondo, Italy Profilin is an actin-binding protein expressed in all eukaryotic cells, regulating microfilament remodelling. Besides actin, it binds to poly-L-proline and phosphatidylinositol …
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Viral subversion of host cell membrane trafficking
Enveloped viruses acquire their membrane coat from the plasma membrane or intracellular organelles and rely on cellular machinery to facilitate envelopment and egress of virus progeny. This thesis examines egress-related interactions between host cell factors and proteins of two different enveloped …
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Elucidating the role of TM9SF2 in membrane trafficking
… destinations. The Golgi comprises sequential membrane-bound, motile compartments called cisternae. The most prominent Golgi modification is glycosylation, the addition of glycans by a group of enzymes called glycosyltransferases. Glycosylation has no template; therefore, it relies on the …
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An evolutionarily conserved regulatory mechanism for endosomal membrane trafficking
Membrane fusion in all eukaryotic cells is facilitated by the formation of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes; a process that is regulated by Sec1p/Munc18 (SM) proteins. Membrane fusion has been conserved through evolution and hence a lot or our …
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
… identify contractile steps and find that when a trafficking pathway initiated by Sbf is disrupted, contractile steps become reversible. Sbf localizes to tubular, apical surfaces and associates with Rab35, where it promotes Rab GTP exchange. Interestingly, when Sbf/Rab35 function is compromised, …
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How to Mend a Broken Heart: Massive Endocytosis and the Role of Lipidic Forces in Membrane Trafficking
Novel forms of membrane internalization defined as massive endocytosis (MEND) were characterized for mechanism and physiological significance in isolated cells and intact cardiac tissue. These non-canonical forms of membrane trafficking are related to perturbations within the outer lipid monolayer …
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
Membrane fusion is a conserved process that facilitates essential events like endocytosis, secretion, cell division and autophagy. Membrane fusion occurs at all organelles, and many of the fundamental processes required for fusion have been extensively studied. This process requires a minimal set …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
The file named "TU-DISSERTATION-2013.pdf" is the primary dissertation file. Twelve (12) supplemental videos are also provided (in Audio Video Interleaved format).
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Role of sedlin, a TRAPP complex subunit, in membrane trafficking and in the pathogenesis of Spondyleopyphiseal Dysplasia Tarda
… I hypothesized that sedlin might exert a role in membrane trafficking generally but in particular in the transport of chondrocyte- specific cargoes, such as type II procollagen (PCII). This hypothesis was reinforced by the fact that mutations in PCII give rise to autosomal dominant forms of …
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The PI5P 4-kinase ortholog PPK-2 of Caenorhabditis elegans acts in synaptic transmission and neuronal membrane trafficking
… Phosphatidylinositole (PIPs) in den Membranen verschiedener Organellen und der Plasmamembran (PM) werden durch PI/PIP-Kinasen und PIP-Phosphatasen reguliert. Mittels eines RNAi-Screens wurden sechs PIP-metabolisierende Enzyme des Rundwurmes Caenorhabditis elegans (C. elegans) …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… between N-glycans and other regulators, such as membrane lipid domains, in the control of signaling pathways remains poorly understood. My thesis therefore focuses on how N-glycans and membrane lipid domains oppose and/or work together at different cellular levels to regulate various processes …
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Competition and band-pass filtering in biology: modelling and experimental validation in membrane trafficking and post-transcriptional gene regulation
L'abstract è presente nell'allegato / the abstract is in the attachment
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
… of the Ras superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and interact with effector proteins to regulate membrane trafficking processes, such as vesicle formation, vesicle …
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Apicomplexan Class XXVII Myosin - A Computational, Biophysical and Cell Biological Characterisation of PfMyoF in Plasmodium falciparum
… in a broad range of cellular activities such as membrane trafficking. Very little is known about the precise functions of the variety of myosins in P.falciparum or how they contribute to pathogenicity. The ultimate aim of this project is to biophysically and functionally characterise the …
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cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
… B2, a member of a family of proteins involved in membrane trafficking. RNAi-mediated knock-down of CPG2 increased the number of postsynaptic clathrin-coated vesicles, some of which trafficked NMDA receptors, and disrupted the internalization of glutamate receptors. In addition, alterations in its …
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Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
… II at the equator in late stages of cytokinesis. Membrane trafficking appears unaffected in anillin-depleted cells, although, unexpectedly, ectopic expression of one membrane trafficking marker, DE-cadherin-GFP, suppresses the cytokinesis defect. DE-cadherin-GFP recruits β-catenin (armadillo) and …
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Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors
… specialized neurons that have high protein trafficking demands. At one end of the photoreceptor is the outer segment; the site of photon detection and phototransduction. The outer segment requires a constant supply of new proteins and membranes to maintain proper function. At the opposite …
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Identification and characterization of components of rab-6-mediated trafficking in caenorhabditus elegans
Membrane trafficking in neurons is an important mechanism used to regulate signaling. Controlling the abundance of AMPA-type receptors at the synapse is important for synaptic plasticity and influences processes involved in learning, memory formation, and motor control (Greger and Esteban, 2007; …
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