Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"membrane rupture"”.
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N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
… pathways. To identify novel regulators of plasma membrane rupture, a hallmark of necrotic cell death, a genome-wide shRNA loss-of-function screen was performed. We identified SNARE complex members, mediators of canonical membrane fusion events, as necessary for Ca2+ and ROS-induced plasma membrane …
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
… to the nucleus, Ad must penetrate endosomal membranes to create defects sufficient for the passage of the 90 nm diameter capsid across cell membranes. Recent observations suggest that adenovirus type 5 (Ad5) capsid uncoating occurs at the cell surface upon binding to both the coxsackievirus …
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
… profile in the placenta and fetal membranes is a necessary requirement for the successful completion of pregnancy since any aberrant variations may lead to the inappropriate timing of birth. Epigenetic regulation through reversible modification of chromatin has emerged as a …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
… of striped gold nanoparticles into live cell membranes via non-endocytic pathways was poorly understood, therefore this work focuses on the interaction of striped NPs with synthetic lipid membranes as models for cellular membranes, and interactions with bacterial membranes have been …
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
… the pH triggered lipid conformation change will rupture liposome membrane, release the encapsulated content, and thus help them escape lysosome degradation. This would in tum improve the efficiency of liposome drug delivery and gene transfection.</p> <p>Luciferase gene transfection was conducted …
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Fluid Shear Stress Effects on Cancer Metastasis
… shear stress can act either directly, causing membrane rupture and cell death, or by altering cell phenotype via mechanotransduction pathways, but to what extent these and other unknown effects have on the metastatic cascade remains unresolved. In vivo models have been limited in their ability …
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Cationic amphiphilic synthetic macromolecules with superior antibacterial activity
… amphiphilic polymers attack bacteria directly to rupture the cell membrane through electrostatic and hydrophobic interactions. However, the toxicity of such synthetic amphiphilic polymers against mammalian cells have impeded their therapeutic applications. We investigated the systematic …
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THE AUTOPHAGIC RECEPTOR P62 MODULATES MICRONUCLEUS STABILITY
… differ from primary nuclei. Micronuclear membrane can undergo rupture and eventually collapse, causing defective nuclear protein import and impaired DNA replication. Micronuclei fail to repair damaged DNA and, if reincorporated into primary nuclei, may lead to the mutagenic event of …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… (Ad5) elicits ROS by inducing mitochondrial membrane damage, a process that is dependent on endosomal membrane rupture and Cathepsin release. This mitochondrial dysfunction contributes to NLRP3 inflammasome- and NFκB-dependent innate immune activation. The ROS-dependent inflammatory response …
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Tumour chemo sensitivity assays: an investigation into the susceptibility of cells to chemotherapeutics
… kinase into the culture supernatant after membrane rupture and is evaluated as an indicator of cell death. This assay was proven to correlate and compete with currently used methodologies for the assessment of cytotoxicity and with its superior sensitivity; convenience and in expense, it …
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Mycobacterium tuberculosis metallomics
… induced cell clumping, and Ag-Cu@SPIONs caused membrane rupture. Transcriptomic analysis revealed that Ag@SPIONs and Ag-Cu@SPIONs disrupted sulphur metabolism and oxidoreductase pathways in Msmeg, while Cu@SPIONs interfered with amino acid and fatty acid metabolism. Against Mtb, Ag@SPIONs, …
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Inflammatory response in maternal serum during preterm labour
… These substances trigger uterine contractions, membrane rupture and cervical ripening. Most intra-uterine infections are chronic and subclinical in nature and consequently hard to diagnose before labour or rupture of the membranes. A tremendous amount of efforts has been expended to identify …