Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"membrane receptor"”.
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Molecular Mechanism of Ferricsiderophore Transport via the Outer Membrane Receptor FhuA in <em>Escherichia coli</em>.
… transport it into the cell via specific outer membrane receptors. The FhuA receptor protein transports ferrichrome, a siderophore produced by <em>Ustilago sphaerogena</em>. We determined the binding affinity of variants from the conserved 'lock region' of FhuA and also created and characterized …
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The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of the uPAR in …
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Characterization of a Catechol-Type Siderophore and the Detection of a Possible Outer Membrane Receptor Protein from <em>Rhizobium leguminosarum</em> strain IARI 312.
… actively transported across the outer and inner membranes of gram-negative bacteria. There are two main classes of siderophores: catechol and hydroxamate. Catechol-type siderophores chelate ferric iron via hydroxyl groups, and hydroxamate-type siderophores chelate ferric iron via a carbonyl group …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
The ErbB family of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of …
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Insulin, added to nuclei, stimulates transcription of specific genes
… following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin …
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SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME
… for efficient new therapies. Interleukin 13 receptor alpha 2 (IL-13Rα2) is an internalized, plasma membrane receptor for IL-13. IL-13Rα2 is over-expressed in around 75 percent of GBM patients. One of our goals is to develop specific therapeutic delivery vehicles and imaging agents …
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An agent-based model of the IL-1 stimulated nuclear factor-kappa B signalling pathway
… the pathway is robust to perturbations of cell membrane receptor component number, intermediate component number, and the temporal lag between cell membrane receptor activation and subsequent activation of IKK. Conversely however, in silico experimentation predicts that the pathway is sensitive …
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Altering the ADIPO: LEP Ratio Secreted by Obese Adipose Tissue affects the Tumor Growth Microenvironment of MCF7 Breast Cancer Cells
… Adiponectin has been shown to bind to its membrane receptor AdipoR1 and activate the cell signalling pathway AMPK, stabilizing the cell cycle inhibitor protein p27, leading to cell cycle arrest. Leptin on the other hand binds to its membrane receptor Ob-Rb and activates the Akt signaling …
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The Effect of Steroid Hormones on Expression of the Leptin Receptors
… in humans and mice. Leptin signals through a membrane receptor, <italic>Ob-R</italic>, and expression of the Ob-R</italic> isoforms are also sexually dimorphic, and suggest that steroid hormones may also control receptor expression. The experiments described here attempt to better understand …
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TARGETING A CANCER-ASSOCIATED BIOMARKER WITH DIAGNOSTIC AND THERAPEUTIC RADIOACTIVITY
… expressing IL13Ra2, a tumor-restricted plasma membrane receptor overexpressed in GBM and other malignancies. Based on prior work, we designed a novel IL13Ra2-Targeted Quadruple Mutant of IL13 (TQM13) to selectively bind the tumor-restricted IL13Ra2 with high affinity but not significantly …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
The epidermal growth factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are …
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Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition
Fetal membranes line the intra-uterine cavity and perform protective functions during pregnancy. Rupture of membranes before term is deemed ‘catastrophic’ and contributes to infection, preterm birth, and neonatal death. During gestation, membranes repair and remodel through a balanced …
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Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks
… problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome and unresponsiveness to endocrine treatment. Although much work has been done over the past decades to …
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes to downstream second-messenger signalling cascades independent of gene regulation. However, nongenomic …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… is achieved by binding two distinct Neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor provides a tractable therapeutic target for multiple cardiovascular diseases, …
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
… set of behaviors involving force-sensitive membrane receptor activity, changes in cytoskeletal contractility and transcriptional regulation. Effective ex vivo model systems are needed to emulate the native environment of a tissue and to translate cell-matrix forces with high fidelity. A …
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The Role of Arabidopsis thaliana Annexins 1, 2 and 4 in Extracellular ATP Signalling
… to Nucleotides) as the first higher plant purinoreceptor has confirmed eATP in plant signalling systems. AtDORN1 is a plasma membrane receptor kinase that appears to command the eATP-induced transient increase in [Ca$^{2+}$]$_{cyt}$ and directs the translational response to wounding. The identity …
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Characterization Of Streptolysin O As The Translocator For The Cytolysin-Mediated Translocation Process In Streptococcus Pyogenes
… host cell cytosol, toxins must cross the plasma membrane, traverse the membrane of endocytic vesicles, or cross the membrane of organelles. The process <underline>c</underline>ytolysin-<underline>m</underline>ediated <underline>t</underline>ranslocation: CMT) in <italic>Streptococcus …
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Investigating Iron Transport and Utilization Features of Acinetobacter baumannii
… and <i>dppBC</i>, components of an inner membrane ABC transporter, did not affect growth under iron-chelation, suggesting alternative transport functions. However, inactivation of <i>cirA</i>, which codes for an iron-regulated outer membrane receptor resulted in reduced growth under …
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