Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"membrane protein folding"”.
-
Towards Understanding Membrane Protein Folding and Stability with Solid-State NMR and Hydrogen/Deuterium Exchange
A comprehensive understanding of membrane protein (MP) folding in the native-like environment is one of the most formidable challenges in protein biophysics. Folding of alpha-helical MPs has been described by a model featuring two energetically and mechanistically distinct stages involving (i) the …
-
Studies of Protein Folding on Membranes and in Crowded Environments and Bridging the Research-Teaching Gap in K-12 Science
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization …
-
Studies of protein folding on membranes and in crowded environments and bridging the research-teaching gap in K-12 science
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization …
-
Role of the Lipid Environment and Cholesterol Content in the Function of CFTR Modulators
… in a gene that codes for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Despite CFTR being a protein located in epithelial cell membranes, it has not been established whether the membrane surrounding CFTR plays a role in the function of the recently-discovered CFTR modulators. In …
-
Structural and Biophysical Characterisation of Denatured States and Reversible Unfolding of Sensory Rhodopsin II
Our understanding of the folding of membrane proteins lags behind that of soluble proteins due to the challenges posed by the exposure of hydrophobic regions during in vitro chemical denaturation and refolding experiments. While different folding models are accepted for soluble proteins, only the …
-
Biogenesis of Multipass Membrane Proteins
Roughly one-fourth of all genes code for integral membrane proteins. Most membrane proteins pass back and forth across the lipid bilayer multiple times. Multipass membrane proteins, such as ion channels and receptors, are essential for nearly all transport and communication across the plasma …