Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"membrane protein biogenesis"”.
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Mechanisms of multipass membrane protein biogenesis
… reagents to improve efficiency. Semi-permeable membranes facilitate autonomy via an outer barrier (plasma membrane) and enclose functional hubs (organelles) to efficiently carry out biological processes. However, cells do not live in isolation and must communicate with neighboring cells, uptake …
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A role for a predicted E. coli inner membrane lipoprotein in cell envelope integrity
… coli</em> is the possession of a double-membraned cell envelope. The outer membrane provides an additional layer of protection against hydrophobic molecules including antibiotics, contributing to the multidrug resistance crisis. The Gram-negative membrane is composed of phospholipids, …
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Uncovering the biogenesis pathways for human mitochondrial alpha-helical outer membrane proteins using genome-wide approaches
Mitochondria are critical double-membraned organelles that act as biosynthetic and bioenergetic cellular factories, with the outer membrane providing an interface with the rest of the cell. In humans, the outer mitochondrial membrane (OMM) contains ~110 different proteins which are encoded in the …
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Biogenesis of Multipass Membrane Proteins
Roughly one-fourth of all genes code for integral membrane proteins. Most membrane proteins pass back and forth across the lipid bilayer multiple times. Multipass membrane proteins, such as ion channels and receptors, are essential for nearly all transport and communication across the plasma …
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Structural Studies of Protein Transport
Most new proteins are made in the cytosol and then targeted to their mature destinations. In the case of integral membrane proteins (IMPs), this targeting concludes with integration into the target membrane, a process typically facilitated by protein-conducting channels. This thesis examines the …