Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 136 for “"membrane permeability"”.
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ACCELERATING WHOLE-CELL BIOCATALYSIS BY ENHANCING OUTER MEMBRANE PERMEABILITY
… cell envelope often represents a formidable permeability barrier. As a result, reactions catalyzed by whole-cells are reportedly orders of magnitude slower than those of by their free enzyme counterparts. The present research addresses this critical issue by using membrane engineering …
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Quantitative In Vitro Characterization of Membrane Permeability for Electroporated Mammalian Cells
… are motivated by the response of biological membranes to high- intensity pulsed electric fields. These fields rearrange the membrane structure to enhance the membrane's diffusive permeability, or the degree to which a membrane allows molecules to diffuse through it, is impacted by the …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
The ABC transporter P-glycoprotein (Pgp) and membrane permeability are determinant factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of …
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Some effects of dimethyl sulfoxide on absorption, translocation, and membrane permeability in plants
… and translocation of herbicides and plant membrane permeability was investigated. Primary leaves of bean (<i>Phaseolus vulgaris</i> L., var. Black Valentine) were treated with ¹⁴C-labeled DMSO, 3,6-dicholoro-<u>o</u>-anisic acid (dicamba), 1,1′-dimethyl-4,4′-bipyridinium salt (paraquat) and …
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
… to show that cold exposure leads to increases in membrane permeability. This membrane permeability is transient, as rewarming of the cells reduces permeability to baseline levels. We also test the role of lipid peroxidation in contributing to membrane permeability and find that although it …
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Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents
… and diagnostic agents because of poor membrane permeability. To increase membrane permeability, we conjugated hydrophobic lipids or phospholipid molecules and hydrophilic cell penetrating peptides to the N and C terminus of PNAs, and studied their physical and biological properties. …
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The Influence of Dietary Cholesterol on 26-Hydroxycholesterol and the Effect of 26-Hydroxycholesterol on the Intracellular Free Calcium Level
… These studies indicated that they affect membrane permeability, cause membrane perturbance, inhibit enzyme activity and cause cellular injury. However, the role of 26-hydroxycholesterol in calcium permeability is still unknown.
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Detergent effects on disinfectant susceptibility of Escherichia coli and listeria monocytogenes attached to stainless steel
… (PI) revealed significant increases in cell membrane permeability of both organisms by all detergents except sodium dodecyl sulphate (SDS) and the effect was much greater in E. coli. Increasing above the in-use concentration of SAS and FAE had no further effect on cell membrane permeability, …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… also revealed that QUB2455 caused increased membrane permeability in MRSA. The stability of QUB2455 revealed that QUB2455 retained good antimicrobial activity in the presence of high concentrations of salts, different pH values, high temperatures and even in serum. Moreover, three peptides, …
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Development of biomimetic, hybrid protein-synthetic membranes: determining protein insertion efficiency, membrane material suitability and relevance of aquaporin Z
Biomimetic membranes are designed to mimic the selective permeability of cell membranes, and can be engineered for a multitude of environmental applications including water purification, remediation, and sensing. Biomimetic membranes consist of membrane proteins, such as the bacterial water channel …
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Influence of environmental factors on molecular transport through bacterial membranes
Bacterial membranes act as protective barriers and help to regulate molecular interactions between a cell and its surrounding environment. External chemical and physical influences have the potential to alter the properties of bacterial membranes and therefore impact the viability of the cell. This …
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Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes
… through either opening of pores in the plasma membrane or other unknown processes which can disturb the membrane in an organized way. However, direct morphological evidence is lacking and responses of intracellular organelles are not clear. We used traditional chemical fixatives and biochemical …
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Characterization of sodium transport at the plasma membrane of Spergularia marina
… either passive exclusion mediated by low plasma membrane permeability or active exclusion of passively acquired Na$\sp{+}$ which has moved down its electrochemical gradient into the cell. Whole plant studies using the halophyte Spergularia marina have demonstrated high permeability for Na$\sp{+}$ …
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Computational studies on polyunsaturated fatty acid uptake and its effects on antimicrobial resistance
… fatty acid transport protein FadL; the second a membrane system interacting with cationic antimicrobial peptides. The FadL uptake study involved the atomistic level modelling of various FadL homologs found in virulent V. cholerae serotypes. Docking of equilibrated FadL homologs presented …
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Pseudomonas aeruginosa Type IV pilus and resistance to the antimicrobial properties of surfactant protein-A
… microbial clearance by opsonization and membrane permeabilization. Pseudomonas aeruginosa (PA) is a major Gram-negative bacterial pathogen commonly associated with chronic lung infection in cystic fibrosis. In order to resist the antibacterial effects of SP-A, PA expresses various …
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Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal
… are two significant obstacles in water treatment membrane filtration. Biofouling reduces membrane permeability, increases energy costs, and decreases the lifetime of membranes. In order to effectively remove viruses, nanofiltration or reverse osmosis (both high energy filtration schemes) must be …
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Effects of conjugated oligoelectrolytes on cell transformation
… surface charge of bacterial cells and increase membrane permeability, which can potenitally increase their competence in accepting exogenous DNA. This study tested the effect of the COE DSSN+ combined with electroporation on the transformation of Escherichia coli cells. Multiple experiments with …
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Comparison of epididymal and ejaculated sperm collected from the same Holstein bulls
… ejaculated sperm. During cryopreservation, the membrane permeability of ejaculated and epididymal sperm was found to be similar. In addition, the membrane permeability of both ejaculated and epididymal sperm was decreased by the inclusion of glycerol during freezing. The optimal cooling rate for …
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Effects of environmental temperature on members of the mucorales
… groups. Subsequent investigations of plasma membrane permeability suggested that plasma membrane structure and function may be significant in establishing both the upper and lower growth temperature limits characteristic of psychrophiles, mesophiles and thermophiles. Analysis of the plasma …
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Ribosomal Synthesis of N-methylated peptides
… target affinity, proteolytic stability or membrane permeability. Therefore synthesis of N-methylated peptide libraries is valuable in screening for drug-like peptides suitable for therapeutic uses. Protein synthesis using recombinant elements (PURE) and Flexizyme were used in order to …
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