Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"membrane mimetics"”.
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HIV-1 Vpu Oligomerization in Membrane Mimetics
… of explicit all-atom simulations of the Vpu transmembrane domain oligomer in a hydrated lipid bilayer, verified the importance of the conserved AxxAxxxAxxxA motif, and characterized the stability of several Vpu oligomeric arrangements both in the presence and absence of water channels. Finally, I …
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Structure-function studies of respiratory complex I from Paracoccus denitrificans using membrane mimetics
… four protons across energy-transducing membranes, contributing to the proton motive force that powers oxidative phosphorylation. Despite recent advances in structural knowledge and extensive biochemical investigations, the mechanism of redox-coupled proton translocation by complex I …
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Conformational ensembles and dynamics of amphipathic aggregates and proteins examined by synergy of NMR experiments and MD simulation
… systems, such as disordered proteins, cellular membranes and other amphiphilic aggregates, are beyond the scope of these methodologies. This thesis demonstrates how these disordered biomolecular systems can be characterized using a combination of Nuclear Magnetic Resonance (NMR) and Molecular …
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Role of the Lipid Environment and Cholesterol Content in the Function of CFTR Modulators
… in a gene that codes for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Despite CFTR being a protein located in epithelial cell membranes, it has not been established whether the membrane surrounding CFTR plays a role in the function of the recently-discovered CFTR modulators. In …