Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"membrane lipid composition"”.
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The membrane lipid composition regulates talin mediated integrin activation
Integrins are a family of transmembrane receptors that mediate cell-cell and cell-extra cellular matrix (ECM) interaction and signaling. Inside-out activation of integrin receptors often requires the binding of the cytoplasmic domain of the subunits by talin. This interaction leads to separation of …
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The Role of Membrane Lipid Composition on Skeletal Muscle Damage in the Rodent Model of Duchenne Muscular Dystrophy
… muscle disease, which leads to alterations in membrane phospholipid fatty acid (FA) composition and skeletal muscle damage. Increased membrane saturated FA in muscular dystrophy may suggest its association with increased susceptibility (as being the cause or consequence) to muscle damage. It …
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The Role of Membrane Lipid Composition on Sarco(endo)plasmic Reticulum Calcium ATPase Function in Rat Soleus Muscle
… reticulum calcium ATPase (SERCA) is a transmembrane protein whose function is regulated by its immediate lipid environment (annulus). The composition of the annulus is currently unknown or it’s susceptibility to a high saturated fat diet (HSFD). Furthermore it is uncertain if HSFD can …
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Understanding the physiological role of the small RNA RydC
… levels of cyclopropane fatty acids in the cell membrane. Here, we show that additional sRNAs, ArrS and CpxQ, also directly regulate cfa post-transcriptionally. RydC and ArrS act through masking an RNase E cleavage site in the cfa mRNA 5' untranslated region (UTR), and both sRNAs …
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A Physicochemical and Biophysical Investigation into the Role of Lysyl- Phosphatidylglycerol in the Membrane of Staphylococcus aureus under mild acidic conditions
… lysyl-phosphatidylglycerol (L-PG) in its plasma membrane. The precise mechanisms by which L-PG facilitates tolerance to acidity and CAMPs remain under-investigated, due to the lipid’s lability in mild aqueous conditions. This study examines the role of L-PG in responses to epithelial defences and …
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Roles of Phospholipase A/Acyltransferase Enzymes in Membrane Remodelling and Organelle Degradation
Biological processes involving changes in membrane structure and properties require cells to adjust their membrane lipid composition accordingly. One of the ways cells can rapidly generate a diverse repertoire of membrane lipids is through remodelling the fatty acid tails of phospholipids. This …
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Influence of plant growth regulators on turfgrass polar lipid composition, tolerance to drought and salinity stresses, and nutrient efficiency
… drought and salinity stress treatment. Total lipids, fatty acid composition of polar lipids, and total free and conjugated sterols were determined by the thin layer chromatograph, gas chromatograph, and scanner densitometer. This study indicates that ppe and FSE affected the unsaturation of …
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Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production
Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry (HPLC-MS), after first developing a sensitive, high throughput molecular ion …
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pH-Triggered Membrane Insertion of Proteins
Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of pH-triggered insertion of membrane proteins, many aspects of this process remain …
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Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production
Intact polar diacylglycerolipids (IP-DAGs) were used to study microbial dynamics in the surface ocean. IP-DAGs from surface ocean seawater were quantified using high performance liquid chromatography-mass spectrometry (HPLC-MS), after first developing a sensitive, high throughput molecular ion …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… techniques: specific growth rate, membrane fluidity, membrane leakage, membrane lipid analysis, hydrophobicity, carboxylic acid production, transcriptome analysis, intracellular pH, γ-amino butyric acid determination, proton motive force simulation, genome reverse engineering, and …
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The Membrane as a barrier or target in cancer chemotherapy
… project was to investigate the role of the cell membrane as a barrier and/or target for drug action and relate this to the development of strategies for overcoming multiple drug resistance (MDR). The effects of doxorubicin on various bacterial strains expressing different levels of anionic …
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Biochemical markers of hypertension and chronic renal failure in a Gulf Arab population of the United Arab Emirates
… glucose, blood urea nitrogen (BUN), creatinine, lipids and lipoproteins were measured by standard colorimetric assays. With regard to hypertension, a major finding of this study is related to the levels of ET-1 in Etniratis with untreated essential hypertension. These were significantly (p < …
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Reconstitution and Mechanistic Studies on the Staphylococcal agr Quorum Sensing Circuit
… reconstitution system based on nanometer-scale lipid-bilayer discs (nanodiscs). Activation of this receptor by its native activator, for instance, requires a membrane environment enriched of anionic lipids mimicking the electrostatic property of the S. aureus cell membrane. This strong …