Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"membrane contact sites"”.
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… not only in the PM but also in the intracellular membranes of organelles, altering their membrane composition and functions. Organelles are dynamic, constantly interacting with each other and the PM through specialized membrane microdomains, known as membrane contact sites (MCS). MCS have distinct …
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Linking Architecture and Function of Endoplasmic Reticulum - Plasma Membrane Contact Sites
… of eukaryotic cells form an intricate network of membrane contact sites (MCS) and thereby promote cellular functions such as lipid metabolism, signalling and organelle biogenesis. The formation of cortical endoplasmic reticulum (cER) - plasma membrane (PM) contacts in budding yeast cells is …
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The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
… of multiple cellular functions including membrane trafficking, sphingolipid metabolism, autophagy, and cell migration. PI4P levels at the Golgi in control conditions are the result of the balanced activity of Golgi-localized PI4-kinases (PI4KIIIβ and to a lesser extent PI4KIIα) and a …
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Characterization of a Novel Fis1 Interactor Required for Peripheral Distribution of the Mitochondrion of Toxoplasma Gondii
… to the pellicle‚ suggesting the presence of membrane contact sites. Upon egress‚ these contact sites disappear‚ and the mitochondrion retracts and collapses towards the apical end of the parasite. Once reinvaded‚ the lasso shape is quickly reformed‚ indicating that dynamic membrane contact …
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Recruitment and function of ORP1L on the Coxiella burnetii parasitophorous vacuole
… (LEL) trafficking, formation of membrane contact sites between LEL and the endoplasmic reticulum (ER), and cholesterol transfer from LEL to the ER. ORP1L localizes to the PV at novel membrane contact sites between the ER and the PV membrane. Ectopically expressed ORP1L in …
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Illuminating Organellar and Molecular Organization of the Endomembrane System
The endomembrane system consists of virtually all of the structurally and functionally distinct membrane compartments in a eukaryotic cell, except mitochondria and plastids. Different compartments in the endomembrane system communicate with each other through vesicular transport as well as direct …
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The interconnected roles of spastin and protrudin in endosomal sorting
… with endoplasmic reticulum (ER)-endosome membrane contact sites and several ER proteins are required for efficient endosomal tubule fission. Our lab has previously identified two hereditary spastic paraplegia (HSP)- associated proteins, spastin (SPG4) and atlastin-1 (SPG3A), as essential …
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An obligate intracellular bacterial pathogen forms extensive and stable interkingdom contacts with the endoplasmic reticulum
… employ various mechanisms to manipulate host membranes, a critical strategy for subverting host pathways and advancing their life cycle. To this end, Rickettsia parkeri directly engages the host plasma membrane to infiltrate target cells and spread to neighboring ones. However, whether this …
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The Role of Mammalian Lipid Transport Protein ORP1 During Coxiella Burnetii Infection
… into the host cell cytoplasm. While the CCV membrane is rich in sterols, cholesterol accumulation in the CCV is bacteriolytic, suggesting that C. burnetii regulation of lipid transport is critical for infection. The mammalian lipid transport protein ORP1L localizes to the CCV membrane and …
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Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry
… at junctions between the ER and plasma membrane (PM). Within these membrane contact sites (MCS), STIM1 forms puncta that trap and activate Orai1 Ca2+ channels in the PM, allowing Ca2+ to flow into the cytoplasm and slowly replenish Ca2+ in the ER. Elucidating the binding stoichiometry of …
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REEP5-MFN1/2 tethering in ER-mitochondria crosstalk
Eukaryotic cells utilize membrane contact sites (MCSs) to mediate communication between organelles, with mitochondria-ER contact sites (MERCs) being among the most extensively studied due to their essential roles in maintaining cellular homeostasis. MERCs facilitate critical processes, including …
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Molecular Architecture of the ER-Mitochondria Encounter Structure
Membrane contact sites (MCS) form between all organelles of eukaryotic cells and facilitate interdependent processes between unique subcellular compartments. In budding yeast, MCS between the endoplasmic reticulum (ER) and mitochondria are mediated by a protein complex known as the ER-mitochondria …
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Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions
Mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) form signalling platforms, which are required for cellular processes such as lipid metabolism, mitochondrial dynamics, mitochondrial Ca2+ signalling and apoptosis. MERCs are vital in coordinating cell fate decisions and their …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… Lysosomal Ca2+ release triggers fusion during membrane trafficking and, through calmodulin, it regulates lysosome size. Luminal Ca2+ is critical for regulation of lysosomal biogenesis and autophagy during starvation through the transcription factor, TFEB. Furthermore, aberrant lysosomal Ca2+ is …
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… IP<sub>3</sub>Rs are tethered on actin near membrane contact sites (MCS) between the endoplasmic reticulum (ER) and plasma membrane (PM), where store-operated Ca<sup>2+</sup> entry (SOCE) takes place. Uncovering the mechanisms that govern IP<sub>3</sub>R regulation is an essential element in …