Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"membrane channels"”.
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A Brownian Dynamics Analysis of Ion Movement in Membrane Channels
… and extend the theory of ion transport through membrane channel. A review of previous theory is presented which includes both Nernst-Planck and Eyring Rate theory approaches. The predictions and assumptions of the two theories are discussed and a unified derivation of both from a more …
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Molecular Mechanisms of Gating, Selectivity, and Transport in Membrane Channels and Carriers
… of materials and information across biological membranes is one of the most fundamental and highly regulated processes in the biology of all living organisms. As lipid bilayers present a significant barrier to the transport of most materials, specialized membrane channels and carriers have been …
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Biochemical and Functional Analyses of PANX1 Variants
… capable of forming large-pore single-membrane channels permeable to signaling molecules such as ATP. In this study, we interrogated different domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel function of PANX1 at the cell …
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Tension-induced tunable corrugation in two-phase soft composites and its properties as a band gap structure
… By stacking 1D composite fibers to form 2D membranes, these corrugations collectively lead to the formation of membrane channels with shapes and sizes tunable by the level of stretch and enable the interfaces to progressively soften and evolve into non-planar geometries characterized by the …
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Development and Integration of Bioinformatic and Electrostatic Techniques With Application to Biological Systems
… and applied to simulate the flux of ions through membrane channels. A procedure for the prediction of ion flow, based on full three dimensional charge distribution a specific pH, and containing no freely adjusted variables, is presented. This procedure is used to gain important insight on the …
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Mechanism and energetics of membrane transporters and channels
… evolved specialized transport proteins called membrane transporters and channels that catalyze exchange of materials across the cell membrane. Membrane trans- porters couple the active transport of their specific substrates against their electrochemical gradient. On the other hand, membrane …
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Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
… a technology based on modified microbial membrane channels or pumps that are introduced into target neurons, which can thereafter be activated by light. This is a powerful means of achieving excitatory or inhibitory control over neurons in a target specific manner. In paper I, we have …
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
… to show that cold exposure leads to increases in membrane permeability. This membrane permeability is transient, as rewarming of the cells reduces permeability to baseline levels. We also test the role of lipid peroxidation in contributing to membrane permeability and find that although it …
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Visualization of cellular signaling by fluorescence resonance energy transfer in response to biochemical and mechanical microenvironments
… it reveals how Ca2+ signaling at the plasma membrane and ER membrane channels can be differently regulated by mechanical stimulation, in particular, distinct roles between active actomyosin contractility and passive cytoskeleton supports. In addition to these Ca2+ signals, I show that …
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Molecular mechanisms of gating and selectivity in transport channels
Transport channels and pores are of fundamental importance for translocation of molecules across the otherwise-impermeable biological membrane. As a conduit for the passage of material, specific membrane channels must accomplish the task of selective transport of molecules, while preventing …
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Artificial Transmembrane Signalling
Cell membranes coordinate a large variety of biological processes by selectively recognising and responding to different external stimuli, and membrane-spanning proteins play a vital role in these signalling pathways. A large number of examples of synthetic membrane channels and transporters have …
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Coincidence detection in the cochlear nucleus : implications for the coding of pitch
… that a model including more realistic inputs, membrane channels, and spiking mechanism, or other mechanisms such as lateral inhibition or spatial and temporal summation over spatially distributed inputs would provide insight into the neural mechanisms that give rise to the robust rate cues …
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Microscopic description of gas permeation and delivery pathways in biological macromolecules
… environments by layers or shells coated not only membrane lipids but also, in some cases, proteins, effectively forming physical barriers against their passage. For instance, catalytic site of many enzymes are sequestered deeply inside, while there is no clearly defined pathways for substrate …
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RegulationofGap Junction Protein,Connexins in Immortalized Human Keratinocytes Cells(HaCaTcells)
… are ordered arrays of intercellular plasma membrane channels that directly link the cytosols of two adjoining cells. Gap junctional intercelluar communication (GJIC) is an important mechanism controlling cellular homeostasis, proliferation, and differentiation. A family of gap junction …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. PANX1 1-89 forms a multimeric complex with wild-type PANX1 at the plasma membrane and augments PANX1 channel activity to promote cancer cell survival soon after cells enter the …
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Computational analyses on the structure-function relation in ion channels
Ion channels are protein molecules, embedded in the lipid bilayer of the cell membranes. They act as powerful sensing elements switching chemicalphysical stimuli into ion-fluxes. At a glance, ion channels are water-filled pores, which can open and close in response to different stimuli (gating), …