Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"membrane biophysics"”.
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Understanding the membrane biophysics of alpha-Synuclein and its role in membrane curvature induction and structural remodeling
… alpha-helical structure upon binding the membrane. aSyn is the major proteinaceous component of insoluble fibrillar Lewy bodies, a hallmark of Parkinson's disease (PD). The precise roles of both native and pathological forms of aSyn remain unclear. However, the interaction of aSyn with …
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Simulation of lipid membrane models at coarse-grained resolution Towards novel methodologies with improved capabilities
… methodologies for simulating biological membranes at coarse-grained (CG) resolution, combining well-established modeling strategies with recent advances in machine learning. It presents an optimized set of lipid representations and parameters for the Martini 3 CG force field (FF), …
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Uncovering Structure-Property Relations in Biomimetic Lipid Membranes with Molecular Additives
… lipid bilayer, the fundamental structure of cell membranes, exemplifies a highly adaptable molecular assembly with characteristics that have been fine-tuned through evolution to meet the diverse functional needs of cells. These bilayers must strike a delicate balance: they need to be sufficiently …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
Plasma membranes are complex supramolecular assemblies comprised of lipids and membrane proteins. Both types of membrane constituents are organized in highly dynamic patches with profound impact on membrane functionality, illustrating the functional importance of plasma membrane fluidity. Exemplary, …
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
… spectroscopy was used to assess plasma membrane fluctuations, and measure the bending modulus and membrane tension in human and macaque red blood cells. Optical tweezers were then used to measure the stiffness of human normocytes, reticulocytes, and macaque RBCs. It was found that …
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An Examination of Oxysterol Effects on Membrane Bilayers Using Molecular Dynamics Simulations
… focuses on understanding the role of biological membranes in cellular processes. I am particularly interested in how small molecules perturb membrane structure and regulate membrane function. Membranes are primarily responsible for segregating different compartments of biological cells from each …
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Mechanisms by Which Apoptotic Membranes Become Susceptible to Secretory Phospholipase A2
During apoptosis, changes occur in T-lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A2 (sPLA2). To study the relevant mechanisms, a simplified model of apoptosis using a calcium ionophore was first applied. Kinetic and flow cytometry experiments provided …
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NUCLEAR ENVELOPE TRANSMEMBRANE PROTEIN DISTRIBUTION AND TRANSPORT STUDIED BY SINGLE-MOLECULE MICROSCOPY
… and cytoplasm by forming a barrier. NE transmembrane proteins (NETs) embedded in either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM) play crucial roles in both nuclear structure and functions, including: genome architecture, epigenetics, transcription, splicing, DNA …
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Solid-state NMR spectroscopy applied to model membranes: effects of polyunsaturated fatty acids
… are taken up into phospholipids in the plasma membrane. Thus the focus here is on the plasma membrane as a site of potential structural modification by DHA. Within cellular membranes, the huge variety of molecules (called lipids) which constitute the membrane suggest inhomogeneous mixing, thus …
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Influence Of Cholesterol And Bilayer Asymmetry On Membrane Protein Distribution In Polymer-Tethered Raft-Mimicking Lipid Membranes
… widely recognized that lipid rafts, which are membrane domains enriched in cholesterol (CHOL) and sphingolipids (SL), play a significant functional role in the plasma membrane. Raft domains particularly affect membrane functionality by causing sequestering of membrane proteins. Underlying …