Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"membrane biology"”.
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Bridging molecular and systems scales in membrane biology
Membrane proteins serve a variety of roles which include mediating transport, serving as a trigger for cellular response, and catalyzing bioenergetic reactions. This body of work uses computational methods to study different aspects of membrane biology. The first two studies presented in my thesis …
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Biophysical Insights into Lipid Oxidation Effects on Membrane Self-Organization and Enzymatic Catalysis Under Extreme Conditions
… the influence of lipid oxidation on plasma membrane self-organization using phospholipid monolayers as model mem- branes. Lipid oxidation was induced by 2,2’-azobis(2-amidinopropane) dihydrochloride (AAPH), and observations from the Langmuir trough technique revealed a consistent increase in …
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The conserved dedA family of E. coli membrane proteins: genetic and topological analysis
… conditional growth defects and alterations in membrane composition. A temperature-sensitive mutant named Lud135 was isolated with mutations in two related, nonessential genes: yghB and yqjA. yghB harbors a single missense mutation (G203D) and yqjA contains a nonsense mutation (W92TGA) in …
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Interfacial modulation of protein function explored through atomistic molecular dynamics simulation
… this dissertation, MD is applied to processes in membrane biology and biofuel research. Through the use of the Highly Mobile Membrane Mimetic (HMMM) to accelerate phospholipid motion, we show that phospholipid tails insert significantly faster than they do in a conventional bilayer, and repeated …
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Dynamics of protein-membrane interactions in drug metabolism and cancer
The cell membrane forms a critical barrier between the environment and the inner biochemical machinery of every life form on earth. Without the membrane, vital metabolic processes almost certainly could not occur. Many of these processes also require proteins present at or even embedded within the …
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Utilizing small molecule probes to study the regulation of proteins by specific phospholipids in membrane bilayers
DSpace SAF Submission Ingestion Package generated from Vireo submission #14494 on 2020-02-28 at 17:12:54
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Secretion of the chitinolytic machinery in Serratia marcescens
… dedicated to moving substrate across the outer membrane. Secretion systems are broadly separated into those that move their substrate across the cell envelope in a single translocation event (one-step systems), and those that are dependent on the Sec or Tat machineries for export to the …
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Structure and Function of the ER-Membrane Complex
The ER-Membrane Complex (EMC) is a highly conserved heterodecameric membrane protein complex, found in the Endoplasmic Reticulum (ER) membrane. The EMC has been implicated in a wide range of processes including viral reproduction, inter-organelle phospholipid transfer, cholesterol biosynthesis and …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
Deletions in the gene coding for the neural cell adhesion molecule 2 (NCAM2) have been found in patients with intellectual disability. Growing evidence indicates that deficits in synaptogenesis and impaired signaling mediated by the insulin receptor and insulin-like growth factor 1 (IGF1) receptors …