Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"membrane asymmetry"”.
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Functional Asymmetry of The Immune Cell Plasma Membrane
… the two leaflets of the bilayer of the plasma membrane. This compositional asymmetry is most prominent for phosphatidylserine (PS), a negatively charged lipid that is found almost exclusively on the cytoplasmic (inner) leaflet of the plasma membrane. This energetically unfavorable asymmetry is …
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Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization
… of KRAS with its regulators, effectors, and the membrane present one such avenue. In this study, we investigated how post-translational covalent and environmental modifications could modulate these interactions of KRAS. Using computational molecular dynamics simulations, nuclear magnetic …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
Plasma membrane resident cholesterol is a key regulator of T cell immunity as it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of …
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Influence Of Cholesterol And Bilayer Asymmetry On Membrane Protein Distribution In Polymer-Tethered Raft-Mimicking Lipid Membranes
… widely recognized that lipid rafts, which are membrane domains enriched in cholesterol (CHOL) and sphingolipids (SL), play a significant functional role in the plasma membrane. Raft domains particularly affect membrane functionality by causing sequestering of membrane proteins. Underlying …
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Synthetic In Vivo Reconstitution of Asymmetric Cell Division
… known to asymmetrically localise to the plasma membrane in many systems. It is known that an asymmetric Par complex is required (in many systems), for orienting the division plane, and for generating asymmetry in the density of microtubules in the anaphase-B central spindle (at least in …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
… of distinct lipid species creates a unique membrane signature for various cellular organelles as well as acts as a localization signal for multiple proteins. Proteins have evolved to contain specific lipid-binding modules crucial for mediating protein-lipid interaction. Numerous human …
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Lipid Composition and Configuration Drive Biophysical Properties of The Mammalian Plasma Membrane
… shotgun lipidomics, our lab confirmed PL class asymmetry and surprisingly measured the endoplasmic leaflet to contain double the number of PLs vs. the exoplasmic leaflet. My re-analysis of classical studies show that PM PL abundance imbalance has been a consistent finding across decades of …