Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"melarsoprol"”.
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
… of point mutations found in a laboratory derived melarsoprol resistant T. brucei stock (STIB 777R) allowed development of a PCR/RFLP based molecular method to identify resistance alleles. By 1999, 20-30% of patients treated in Omugo, NW Uganda were failing to respond to melarsoprol. PCR/RFLP …
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Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2
… of the drugs used clinically, pentamidine and melarsoprol. TbAQP2 mutations or the formation of a chimeric gene with TbAQP3 (TbAQP2X3) cause pentamidine-melarsoprol cross-resistance (PMXR). TbAQP2 is an aquaporin, a type of water permeable pore forming integral membrane protein, which typically …
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Synthetic strategies for potential trypanocides
… of these compounds. The sleeping sickness drugs melarsoprol and pentamidine contain P2 motifs. Compounds comprising a P2 targeting motif, a linker and a trypanocidal moiety were synthesized. Initially, a diaminotriazine P2 motif was attached to a trypanocidal tetrahydroquinoline (THQ) protein …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… 1 compounds are on a par with pentamidine and melarsoprol. No major cross-resistance was displayed by the TbAT1 knockout strain to either Series 1 or the GJS series. Similarly, a panel of Series 1 compounds tested against the B48 strain (resistant to pentamidine and melaminophenyl arsenical …