Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"melanosome"”.
-
Role Of Type Ii Phosphatidylinositol 4-Kinases In Endosomal Tubule Dynamics During Melanosome Biogenesis
Melanosomes are pigment cell-specific lysosome-related organelles (LROs) in which melanin pigments are synthesized and stored. Melanosome maturation requires biosynthetic delivery of melanogenic enzymes (e.g. TYRP1), transporters (e.g. OCA2), and SNAREs (e.g. VAMP7) from early endosomes (EEs). One …
-
Regulation of Bidirectional Microtubule-Dependent Organelle Transport in Xenopus Laevis Melanophores
… which contain pigment-filled organelles termed melanosomes that can be aggregated to the perinuclear region or dispersed throughout the cytoplasm by the motor proteins kinesin-2, cytoplasmic dynein, and myosin V. While the motor proteins responsible for melanosome transport have been identified, …
-
Identification of the TPC2 interactome reveals TSPAN10 and OCA7 as key players in the biogenesis of melanosomes
… maturation. One well-studied model LRO is the melanosome, the organelle in melanocytes and retinal pigment epithelial cells responsible for melanin pigment production in the eyes, hair, and skin, and defects in melanosome function lead to pigmentation diseases such as oculocutaneous albinism. …
-
Petrogenesis of a migmatite, Penobscot County, Maine: ultrametamorphism or intrusion?
… red-brown biotite). They are conformable with melanosome (Bucksport) layering, and vary in outcrop from 7-88% areally, and in composition from tonalite to alkali granite. Igneous textures in leucosomes argue against a solid-state origin, while biotite and plagioclase analyses indicate that …
-
Melanin as an Oto-Protective Pigment in Two Fish Species: <i> Poecilia Latipinna </i> and <i>Cyprinus Carpio </i>
… electron microscopy (TEM) was used to examine melanosome structure in the crus commune of the inner ears. For each color morph and species, hearing thresholds were quantified before and after sound exposure (150 Hz tone at 165 dB re 1 μPa for 48 h) by measuring auditory evoked potentials …
-
Signals Regulating Organelle Transport in Melanophores
… of regulation of motor proteins driving melanosome transport, the phosphorylation states of the motors and the levels of motors on the organelles were examined. Immunoprecipitation of myosin V showed that the motor subunit is more heavily phosphorylated in cells aggregating pigment …
-
New tools for the discovery of pigment gene function
… of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions. Here, we describe the MelanoIP method for rapidly isolating melanosomes and profiling their labile metabolite contents. We use it to study MFSD12, a …
-
Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
… synthesis but also act as immunocompetent cell. Melanosome and melanin in melanoyctes have antimicrobial function. In this study, we focused that microbial induced pigmentation may be related to TLRs in human skin. Therefore we investigated whether TLRs are expressed in melanocytes and played a …
-
The cellular basis of the Southern African forms of rufous & tyrosinase-positive oculocutaneous albinism
… ephelides, numerous fully melanised stage IV eumelanosomes, in addition to unmelanised stage I melanosomes, were seen in the melanocyte cytoplasm. Both stage IV and unmelanised stage I melanosomes are transferred to keratinocytes. In ephelis-free regions the melanocyte cytoplasm was filled with …
-
Mechanisms and Regulation of Organelle Transport in Xenopus Melanophores
… to cyclically transport pigment granules, termed melanosomes, either to aggregate to the cell center or disperse throughout the cell in response to hormonal stimulus to effect color changes in the animal. We developed protocols for the biochemical purification of melanosomes from an immortalized …
-
An ultrastructural and light microscopic study of melanocyte differentiation in chick embryos
… are thought to differentiate into either eumelanosome- or pheomelanosome synthesizing cells. To test the validity of this concept, embryonic skin of the red/black cross breed were screened for possible mixed type melanocytes by electron microscopy. The melanocytes contained melanosomes with …