Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"melanoma tumor"”.
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<i>In Vivo</i> Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment
… pulsed electric fields (nsPEF) were applied to melanoma tumors to observe functional and structural biological changes and to investigate the possible molecular mechanisms responsible. An animal model was set up by injecting B16F10 mouse melanoma cells into SKH-1 mice. A treatment (Tx) of 100 …
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Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3
… regulates autotaxin through NFAT1 and support melanoma progression. These findings prompted us to further study the role of NFAT1 in melanoma progression and metastasis. NFAT1 is a transcription factor that was first identified in immune cells, acting as a positive regulator of interleukin-2 by …
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
Treatment of metastatic melanoma with tumor reactive T cells (adoptive T cell therapy, ACT) is a promising approach associated with a high clinical response rate. However, further optimization of this treatment modality is required to increase the clinical response after this therapy. ACT in …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
… (V600E) in a significant fraction of cutaneous melanomas, leading to constitutive activation of the MAP kinase pathway. This genetic lesion endows tumor cells with proliferative and survival advantages, and metastatic melanoma patients treated with the BRAF(V600E)-specific inhibitor, …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
<p>Interferon-gamma (IFN-γ), a well-studied pro-tumorigenic cytokine in melanoma, has been shown to upregulate programmed death‐ligand 1 (PD‐L1) on the melanoma cell. The interaction between PD-L1 and its receptor PD-1 inactivates T-lymphocytes, allowing melanoma cells to escape from immune …
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Activating The 4-1Bb Pathway For The Expansion of Tumor-Infiltrating Lymphocytes For Adoptive T-Cell Therapy For Metastatic Melanoma Patients
… project focused on improving the quality of the tumor-infiltrating lymphocytes (TIL) used in Adoptive T-cell therapy by understanding the role of 4-1BB/CD137 co-stimulation during the expansion of the tumor-infiltrating lymphocytes (TIL). Adoptive T-cell therapy using TIL is a promising therapy …
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
Genomic diversity and adaptive plasticity of melanoma tumors limit durable control with conventional and targeted therapies. Nevertheless, pathological activation of the ERK1/2 regulatory system is a linchpin tumorigenic mechanism associated with the majority of both primary and recurrent disease. …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… topical administration, for treatment of non-melanoma skin cancers. Our group investigates hypericin-induced PDT (HYP-PDT) for the treatment of both non-melanoma and melanoma skin cancers. However, a prerequisite for effective cancer treatments is efficient and selective targeting of the …
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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
<p>Malignant melanoma is the most dangerous form of skin cancer and accounts for about 75% of skin cancer deaths. Once diagnosed at the metastatic stage, it has a very poor prognosis with a median survival rate of 6 months and a 5-year survival rate of less than 5%. In addition, melanoma has become …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… Blockade Reduces Immune Suppression in the Early Tumor Micro-Environment</p> <p>Brenda Melendez, B.S.</p> <p>Advisory Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier against …
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Design and development of an RNA vaccine against tumor-mediated angiogenesis and metastasis targeting a KLH-Adrenomedullin fusion protein
… response. AM is overexpressed by most solid tumors, which makes it a good target for anti-tumor therapy. In this study, we designed and tested a mRNA vaccine directed against a fusion antigen composed by a small piece of keyhole limpet hemocyanin (KLH), as a hapten, and mouse AM. The in …
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Rare-Earth Nanoparticles for Non-invasive In Vivo Imaging of Immune Cells in Cancer Immunotherapy
… Studies have shown that the infiltration of tumors by immune cell subtypes is one of the most significant prognostic indicators of disease-free survival across a large number of cancers. However, we remain limited in our ability to non-invasively sample the continuously evolving tumor …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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Tumor Immunotherapy: Mechanisms of Acquired Resistance and Characterization of Immune Related to xicities
<p>Tumor immunotherapy has shown very promising clinical benefit across an array of cancers; however, two major challenges remain unresolved in the field. First, many patients do not respond to therapy at all or relapse after a period of remission. Second, there are often dose-limiting immune …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… to be a clinically effective strategy to enhance tumor specific immune responses. Recently discovered novel immunoglobulin superfamily ligand V-domain Ig suppressor of T-cell Activation (VISTA) is a new target for immunotherapy. VISTA expression is specifically upregulated on tumor infiltrating …
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Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
<p>Metastatic melanoma, a prevalent and deadly form of skin cancer, remains an aggressive clinical outcome that lacks effective preventative and/or curative therapeutics. Patients diagnosed with advanced metastatic melanoma face a dreaded 10-year survival rate of less than 10%. By performing in …
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Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
Over the past few decades, our knowledge of tumor immunology and the role antitumor immune responses play in tumor recognition and eradication has greatly increased and led to immunotherapies being investigated as a promising strategy for cancer treatment. Current clinical studies with various …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… expression or function has been shown to impede tumor growth, induce apoptosis, and sensitize tumor cells to radiation and chemotherapy in different human tumor models. Chapter 2 describes our discovery of a series of novel survivin inhibitors based on the hydroxyquinoline scaffold from our …
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Characterization of molecular dynamic changes in tissue model systems using Fourier transform infrared spectroscopic imaging
… For instance, the endogenous changes within tumor tissues induced by interactions between tumor and stroma are not only indications of tumor initiation and progression for disease diagnosis and prevention purposes, but also an important piece of information for studying the underlying disease …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… of selected molecular targets in canine tumors, focusing on aggressive, frequent, or therapeutically challenging neoplasms, and to evaluate their suitability as druggable candidates for targeted therapy and as comparative models for human cancer. The approach combined …
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