Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"melanogenesis"”.
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Pleiotrophin inhibits melanogenesis in normal human melanocyte
… study, we investigated whether PTN would affect melanogenesis. PTN was expressed in melanocytes and fibroblasts of human skin. Transfection studies revealed that PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes. The inhibitory action of PTN in …
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The control of melanogenesis in early avian embryos
The developing neural crest in avian embryos presents a unique system for the investigation of cell migration and differentiation. A variety of histological, cellular and molecular techniques have been used in this study to explore and clarify the exact sequence of events occurring during the …
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Wnt Inhibitory Factor (WIF)-1 Promotes Melanogenesis in Normal Human Melanocytes
… Wnt antagonists. There is no study available on melanogenesis effect of human melanocytes. Objectives: In this study, we investigated the expression of WIF-1 in human melanocytes and the effects of WIF-1 on melanogenesis. Method: To determinutese whether WIF-1 is expressed in human melanocytes, …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
Inflammatory cytokines are closely related to melanogenesis in melanocytes. Here, I studied whether IFN-γ affects melanogenesis, and if so, what is the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase …
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A comparative study of putative melanogenic and melanogenesis inhibiting substances in the vertebrate integument.
It has been suggested that vertebrate pigment patterns are determined and maintained by factors which are present in the integument. The research reported in this dissertation provides some evidence in favor of this supposition. Examination of the deer mouse, Peromyscus boylei, demonstrated that …
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Regulation of melanogenesis in conditionally immortalised mouse melanocytes expressing a temperature-sensitive SV40 large T antigen
… to investigate the stimulatory effect of TPA on melanogenesis because growth curves showed that the cells become TPA-independent. The results showed that stimulation of melanogenesis by TPA in a pigmented melanocyte line, DMEL-2, resulted in an increase in tyrosinase, TRP-1 and TRP-2 proteins and …
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Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
… As results, sFRP2 and WIF-1 stimulated melanogenesis in normal human melanocytes through the increased expression of MITF and tyrosinase via β-catenin signaling. Moreover, the epidermal pigmentation of human skin was also increased in the presence of recombinant human sFRP2 and WIF-1. …
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The genetic basis of plumage polymorphism in the black sparrowhawk
… morph were found in the coding regions of the melanogenesis genes melanocortin 1 receptor (MC1R), agouti signalling protein (ASIP), or proopiomelanocortin (POMC). However, the expression levels of several genes involved in melanogenesis differed between the two morphs, with light morph …
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Pax3 expression in cutaneous malignant melanoma
… expression in normal murine embryogenesis and melanogenesis, identifying a conserved role for the Pax3d protein in transcriptional regulation of the murine melanoblast. Furthermore, to identify a role for Pax3 in adult skin, we used a reliable time-scale for the strict coupling of melanogenesis …
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An in vitro investigation of the effect of Khellin and UVA (KUVA) on normal and transformed human melanocytes
… To test the effect of khellin, UVA and KUVA on melanogenesis, standard radiometric assays were carried out. The combination of khellin and UVA enhanced melanogenesis of the melanocytic cells more significantly than khellin alone or UVA alone. The dose of 0.01mM khellin plus 250mJ/cm² UVA …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
… and played a role in microbial-induced melanogenesis. First, the mRNA expression of TLR2, TLR4 and their adaptor proteins, CD14 and myeloid differentiation factor-88 (MyD88) was shown by RT-PCR. Protein expression and localization of TLR2, TLR4 and CD14 were detected by western blot, …
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Characterisation and functional analysis of the chicken microphthalmia gene
… little is known about the regulation of avian melanogenesis. There has only been one report of the characterisation of the chicken tyrosinase gene promoter, and only one full-length chicken microphthalmia cDNA (cmi9) has been identified to date.
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Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes
… events including catecholamine synthesis, melanogenesis and insect cuticle sclerotization. These pathways are highly regulated in both insects and mammals by many well-characterized enzymes including dopa decarboxylase and tyrosine hydroxylase. On the other hand, there are still many …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… and PPAR-γ modulates melanocyte growth and melanogenesis. In this study, I investigated the effects of PPAR-γ activators on melanocyte growth and apoptosis. I further examined the regulation of extracellular signal regulated kinase (ERK) pathway under ciglitazone treatment. METHODS: The …
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Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy
… KC. In addition, PDT has inhibitory effect of melanogenesis in the human MC. This inhibitory effect of melanogenesis thought to be regulated indirectly by KC and FB as well as directly by PDT. Decreased secretion of SCF from KC and HGF from FB may have crucial role which induce inhibition of …
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