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Showing 1 to 20 of 32 for “"meiotic recombination"”.
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Genetic strategies to manipulate meiotic recombination in Arabidopsis thaliana
… gametes from a single diploid parental cell. In meiotic S-phase homologous chromosomes, which were inherited from maternal and paternal parents, are replicated. Homologous chromosomes then pair and undergo reciprocal crossover, which generates new mosaics of maternal and paternal sequences. …
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Understanding Meiotic Recombination and Genomic Organisation of Plant Species
… exchange of eukaryotic genetic material during meiotic crossing over is a major source of genetic variation in sexually reproducing species. Crossover events are not distributed randomly along chromosomes and some regions of the genome, like the centromeres, rarely undergo recombination. …
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The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… which are predominantly repaired via homologous recombination. During this process, the homologous chromosomes pair and reciprocally exchange genetic information, also called crossovers. Crossovers break the linkage between genes and create new combinations of alleles which are inherited in the …
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The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… undergo reciprocal exchange, called crossover. Meiotic recombination initiates from DNA double strand breaks, which are repaired using either sister or homologous chromatids as templates. When meiosis occurs in heterozygous (hybrid) organisms, interactions between homologous chromosomes have the …
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Investigating R gene evolution by meiotic recombination using synthetic gene clusters in Arabidopsis
… cluster (synthRPP1) to model R gene evolution by meiotic recombination. This experimental design utilizes gain-of-luciferase phenotype (luc+) to identify and isolate recombinant R genes and uses two alternatively marked alleles to distinguish and measure different types of meiotic recombination …
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A forward genetic screen to identify factors that control meiotic recombination in Arabidopsis thaliana
Meiotic recombination promotes genetic variation by reciprocal exchange of genetic material producing novel allelic combinations that influence important agronomic traits in crop plants. Therefore, harnessing meiotic recombination has the potential to accelerate crop improvement via classical …
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Using Synthetic Gene Clusters to Model Resistance Gene Evolution by Meiotic Recombination in Arabidopsis thaliana
… There is data that supports the relevance of recombination in the evolution of resistance gene clusters in plants. However, a more comprehensive understanding of the molecular biology of recombination and the impact recombination has on R gene evolution is necessary. The objectives of this …
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The Role of Epigenetics in the Regulation of Meiotic Recombination in Triticum aestivum and Arabidopsis thaliana
… formation is an outcome of the process of meiotic recombination, a cascading series of events during which homologous chromosomes undergo pairing and reciprocal exchange of genetic information. During meiotic recombination, meiotic DSB formation and crossover localization is negative …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… by a product of DNA repair by homologous recombination called crossovers, which involve a reciprocal exchange of homolog arms. However, before a crossover can be made, the homologs first have to come together and align along their lengths. This is a process called pairing. In humans and …
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Investigation of natural genetic modifiers of meiotic crossover frequency in Arabidopsis thaliana
Meiotic recombination, known as crossover, is a vital mechanism for generating genetic diversity in sexually reproducing populations. Recombination events are non-uniform across the genome, due to a variety of influences including chromatin structure, DNA-sequence, epigenetic marks and interference …
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Analysis of cell cycle surveillance mechanisms in meiosis
… are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple DNA repair and microtubule integrity to …
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Meiotic Dna Re-Replication And The Recombination Checkpoint
… one round of DNA replication precedes programmed recombination and two nuclear divisions. Cyclin dependent kinase 1 (Cdk1) is required for meiosis, and any disruption in its activity leads to meiotic defects. The Cdk1 inhibitor, Sic1, regulates the G1-S transition in the mitotic cell cycle and the …
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The Evolution of Recombination Landscapes and Mechanisms in Drosophila in Light of Intragenomic Conflict
Sex and recombination are ubiquitous across the vast majority of life on earth. In eukaryotes, recombination during meiosis yields new variation that selection acts upon and, thus, facilitates evolution. However, meiosis provides an arena for manipulation and exploitation by selfish genetic …
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Mouse hybrid sterility genes linked to chromosome X
… smaller testes, no sperm in the epididymis, meiotic pachytene arrest, and high rates of asynapsed autosomes. The first hybrid sterility locus in vertebrates was mapped to chromosome 17 and named Hybrid sterility 1 (Hst1), which was later identified as Prdm9 gene. The Prdm9-interacting hybrid …
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Variation in Recombination Rate on BTA23: Fine Mapping and Construction of a YAC Contig
… the underlying molecular basis for variation in meiotic recombination rate.
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Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
… (HFE) to investigate the impact of meiotic recombination events upon haplotype structure in this region. First we identified crossover hotspots in order to define the boundaries of haplotype blocks in this locus. We then found that gene conversion events play a significant role in …
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The effect of temperature stress on recombination in barley
… is ultimately dependent on the process of recombination which is responsible for the generation of different genotypes with new allelic combinations. The control of meiotic recombination is increasingly being considered as a possible means of aiding plant breeding to tackle the challenges …
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Safeguarding the mitochondrial genome: identifying components of the mtDNA repair machinery
… an MCM helicase that is known to be involved in meiotic recombination. However, recent work in our lab showed that it also localises to mitochondria in Drosophila and human cells, suggesting that nuclear DNA repair proteins could be co-opted to maintain mitochondrial genome integrity. I performed …
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Higher Order Chromosome Organization and Recombination Dynamics of Meiotic Prophase I In Mouse Spermatocytes
<p>Meiotic recombination is required for parental chromosomes to find each other (pairing/synapsis) and to exchange genetic information thus allowing faithful segregation of chromosomes and the production of haploid gametes. At the start of meiotic prophase I, meiotic chromosomes organize into loop …
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Distortions of the genetic map of chromosome I in Caenorhabditis elegans
… effects of sex, mutation, and rearrangement on meiotic recombination in Caenorhabditis elegans were investigated. The short life cycle and existence of meiotic mutants make this organism an ideal system in which to study meiosis. To determine the effect of sex on meiotic recombination, crossing …
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