Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"meiotic"”.
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Study of meiotic chromosomal structure and molecular mechanisms of meiotic prophase I
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Meiotic defects in infertile men
… Thus, we hypothesized that defects in early meiotic events may contribute to both male infertility and the production of aneuploid sperm. We used immunofluorescent techniques to observe the synapsis and recombination of chromosomes during meiosis, and fluorescent in-situ hybridization (FISH) …
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Meiotic regulation of cyclin-dependent kinases
… microtubule-kinetochore interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I chromosome segregation pattern. Premature interactions of kinetochores with microtubules transform meiosis I into a mitosis-like division by disrupting two key meiosis I …
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Equine Spermatogenesis: Meiotic Chromosome Behavior and Recombination
… I (MI) and prophase I (PI) stages of the first meiotic division. Meiotic recombination is considered to be the major outcome of meiosis. It is essential for proper chromosome segregation and formation of normal haploid gametes. Analysis of recombination frequency and distribution are crucial for …
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Meiotic Dna Re-Replication And The Recombination Checkpoint
… and any disruption in its activity leads to meiotic defects. The Cdk1 inhibitor, Sic1, regulates the G1-S transition in the mitotic cell cycle and the analogous transition in meiosis. We have employed a form of Sic1, Sic1deltaP<sup>HA</sup>, that is mutated at multiple phosphorylation sites …
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Defining Tumorigenic Contributions of Meiotic Cancer-Testis Antigens
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The examination of mechanisms underlying meiotic chromosome segregation
… the cell division by which gametes are produced. Meiotic chromosome segregation differs from Mitotic segregation in that one DNA replication phase is followed by two chromosome segregation phases. This allows generation of haploid products from a diploid precursor cell and depends on a number of …
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Gene expression changes during mammalian male meiotic initiation
… haploid gamete generation. Germ cells undergo meiotic initiation, the transition from the mitotic cell cycle to the meiotic cell cycle, once in a generation. In mammals, genetic studies have identified key regulators of meiotic initiation. However, a holistic assessment of the transcriptional …
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INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional sperm, molecular mediators that regulate spermatogonial differentiation and …
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Genetic strategies to manipulate meiotic recombination in Arabidopsis thaliana
… gametes from a single diploid parental cell. In meiotic S-phase homologous chromosomes, which were inherited from maternal and paternal parents, are replicated. Homologous chromosomes then pair and undergo reciprocal crossover, which generates new mosaics of maternal and paternal sequences. …
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Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Understanding Meiotic Recombination and Genomic Organisation of Plant Species
… exchange of eukaryotic genetic material during meiotic crossing over is a major source of genetic variation in sexually reproducing species. Crossover events are not distributed randomly along chromosomes and some regions of the genome, like the centromeres, rarely undergo recombination. …
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A study of the meiotic stability of certain Agrotricum hybrids
Call number: LD2668 .T4 1953 M35
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A study of the meiotic stability of certain Agrotricum hybrids
Call number: LD2668 .T4 1953 M35
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Identifying natural modifiers of meiotic crossover frequency in Arabidopsis thaliana
… terms pertaining to protein modification and meiotic processes. These results further demonstrate the existence of genetic modifiers of crossover frequency in natural populations of A. thaliana, and the characterisation of a novel trans-modifier of recombination, TAF4b. This signifies a novel …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
Tumors frequently activate the expression of genes that are only otherwise required for meiosis. These Cancer Testes Antigens (CTAs) have been found to play critical roles in multiple cellular processes when aberrantly expressed in cancer. Here I found that the CTAs SPO11, GAGE and HORMAD1 play …
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The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… which are inherited in the offspring population. Meiotic crossover events can be beneficial to plant breeding programmes, because they facilitate the introgression of alleles from wild crop relatives to elite cultivars. However, crossover distributions are non-random and with recombination …
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The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… undergo reciprocal exchange, called crossover. Meiotic recombination initiates from DNA double strand breaks, which are repaired using either sister or homologous chromatids as templates. When meiosis occurs in heterozygous (hybrid) organisms, interactions between homologous chromosomes have the …
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A role for the histone variant HTZ1 in meiotic chromosome segregation
… H2AZ homologue, Htz1, resulted in classical meiotic defect phenotypes such as reduced sporulation efficiency, impaired spore viability, and displayed a reduced ability to progress through meiosis. Htz1 deletion strains also showed an increase in chromosome nondisjunction during both meiosis I …
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A molecular characterization of the meiotic initiation factor STRA8 in mice
… haploid gametes. In most organisms, accurate meiotic chromosome segregation depends on the pairing and synapsis of homologous chromosomes and crossing over during prophase of meiosis I. These chromosomal events are generally conserved across eukaryotes and have been extensively studied. In …
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