Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"megakaryopoiesis"”.
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Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis: transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet
The aim of this project was to investigate the transcriptome of human haematopoietic stem cells (HSCs), megakaryocytes and platelets to gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the …
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Molecular regulation of BRD3 in forward programming of Megakaryocytes
… project, I studied the functions of BRD3 during megakaryopoiesis, the process that leads to platelet formation. Because platelets do not have nucleus, megakaryocytes are the best model to study chromatin interactors associated with platelet traits. I used CRISPR/Cas9 to generate a BRD3 KO iPSc …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
… on microenvironmental regulation of myelopoiesis/megakaryopoiesis in response to neuronal inputs. During normal ageing, HSC niches decrease near bone but expand further from bone. Adrenergic signalling regulates lymphoid-myeloid balance during ageing. Whereas β2-AR promotes myeloid and …
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
… ([Ca2+I]) as an important element during megakaryopoiesis. Importantly, CALR mutations impaired the cellular ER Ca2+ buffering activity and led to changes in the [Ca2+I] during the process of megakaryocyte differentiation. In addition, initial experimentsrevealed that physical manipulation …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… be specifically required for the maintenance of megakaryopoiesis and HSC function.In summary, our studies provide novel insights into the essential role of ZFP36L2 in the maintenance of HSC throughout both developmental stages and adulthood. We demonstrate that ZFP36L2 is essential for …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… <p> Examining the role of D221EKLF in megakaryopoiesis, I observed inhibition of megakaryocytic progenitor expansion in D221EKLF fetal hematopoietic cell populations when compared to EKLF-null embryos. Molecular analysis of D221EKLF erythroblasts reveals i) binding of theD221EKLF<sup> …
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Evaluating the Diagnostic Value and Molecular Mechanisms of Thrombocytosis in Lung Cancer
… medium containing established drivers of megakaryopoiesis and thrombopoiesis (p<0.001). These findings provide evidence of a direct mechanistic link between lung cancer cells and platelet biogenesis and suggest activation of a non-canonical pathway thrombopoietic pathway. Collectively, …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
… cells, as shown by bone marrow transplantations. Megakaryopoiesis is upregulated in Crlf3-/- mice and proplatelet morphology is unaffected, suggesting the thrombocytopenia is due to increased platelet clearance. Indeed, splenectomised Crlf3-/- mice show normalised platelet counts within 7 days, …
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The Role of Platelets In Ovarian Carcinoma
Platelets represent one of the largest storage pools of angiogenic and oncogenic growth factors in the human body. The observation that thrombocytosis (platelet count >450,000/uL) occurs in patients with solid malignancies was made over 100 years ago. However, the clinical and biological …