Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"medium-chain"”.
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Lignocellulosic fermentation of Saccharomyces cerevisiae to produce medium chain fatty alcohols
The effects of climate change have made the need to develop sustainable production practices for biofuels and other chemicals imminent. The development of the green economy has also led to many industries voluntarily improving the sustainability of the products they produce. The microbial …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
Metabolism of medium-chain fatty acids (MCFA) is considered to be independent of carnitine because of their passive diffusion into the mitochondrion. However, upon feeding medium-chain triglycerides (MCT) to piglets (n = 16) followed by serial blood sampling, we observed significant changes in free …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
Medium chain length-PHAs (MCL-PHAs) have properties that make them exceptional for applications in cardiac tissue engineering. Cardiovascular diseases (CVD) are a major cause of death worldwide. Cardiac patches aim to facilitate the normal functioning of the heart muscle by providing repair and …
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The Epidemiology and Health System Impact of Medium-Chain Acyl-CoA Dehydrogenase Deficiency Among Affected Children and Those with False Positive Newborn Screening Results in Ontario, Canada
… the epidemiology and health system impact of medium-chain acyl-CoA dehydrogenase deficiency (MCADD) in Ontario. Methods: Following a review of methods to estimating robust health event rates for small populations, this study described health services use among infants diagnosed with MCADD or …
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Modular pathway engineering of microbial fatty acid metabolism for the synthesis of branched acids, alcohols, and alkanes
… contexts. Highly reduced and branched alkyl chains are potentially interesting targets for both flavor and fragrance compounds and as liquid fuel components. Here we report the engineering of microbial fatty acid synthesis to provide both CoA-dependent and fatty acid synthase platforms for …
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Effect of colostrum supplementation on baby pig performance
… (1.5 ml containing glucose, dried milk, medium chain triglycerides, and tea extract), and bovine colostrum (30 ml). The supplements were given as an oral gavage. A single treatment was administered at 6-h after birth. At 30-h of age approximately 1ml of blood was obtained for an …
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Modulation of Hepatic Lipid Metabolism by Dietary Fats in Neonatal Pigs: Implications for Steatotic Liver Disease
… steatosis develops as early as day 7 in pigs fed medium-chain fatty acid (MCFA)-rich formulas and rapidly progresses to steatohepatitis by day 14, independent of whole-body adiposity. In Study Ib, we identified a paradoxical metabolic state characterized by simultaneous upregulation of lipolytic …
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THE SYNTHESIS OF SILICON-MODIFIED LIPIDS AND THE INVESTIGATION OF THEIR SURFACE PROPERTIES
… of octanoyl, lauroyl, and palmitoyl acyl chains to be coupled with 1-(3-aminopropyl)silatrane using 1,1’- carbonyldiimidazole and succinic anhydride. These short, medium, and long-chain models were then subjected to dynamic light scattering analysis after vortexing for 15 minutes in …
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Studies of Lipoic Acid Related Enzymes
… 60.4 KDa protein that shared high homology with medium chain fatty acid-CoA ligases. I expressed the His-tagged protein at a high level in E. coli and purified it to homogeneity. To explore the physiological application of this enzyme in E. coli fatty acid metabolism, I constructed the first E. …
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APPLIED MICROBIAL ECOLOGY OF ANAEROBIC REACTOR MICROBIOMES
… wastes or biomass residues into mainly short-chain carboxylates with two to five carbon atoms. The short-chain carboxylates can be converted into the highly reduced end product methane by methanogenic consortia in anaerobic digestion. Microbial chain elongation such as via the reverse …
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Construction of comparative and framework linkage maps for the identification of quantitative trait loci in cattle
… (SSCP) were identified in the bovine genes for medium chain acyl-CoA dehydrogenase (ACADM), liver/bone/kidney alkaline phosphatase (ALPL), amylase 1 (AMY1), antithrombin III (AT3), Gardner-Rasheed feline sarcoma (v-fgr) oncogene homolog (FGR), alpha-L-fucosidase 1 (FUCA 1), interleukin 10 …
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Feasibility of a Dietary Intervention Using Coconut Oil on Cognition and Quality of Life in Older Adults: Randomised Controlled Pilot study.
… Impairment (MCI). Previous studies have used Medium Chain Triglycerides (MCTs) and ketogenic diets as a source of ketone bodies to improve cognitive functions in older adults with MCI or Alzheimer’s disease. However, the current study relies on the consumption of the whole food component …
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Synthetic sensing systems in Saccharomyces cerevisiae
… signaling pathway, allowing yeast to detect medium chain length fatty acids, alcohols and aldehydes for the first time. Functionally expressing heterologous olfactory receptors in yeast is a challenging task because no definitive method exists on how to express such receptors on the yeast …
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Transition metal oxide layered materials as catalyst and precatalyst for green energy applications: Oxygen evolution reaction and Fischer-Tropsch synthesis
… catalysts for the production of small to medium chain hydrocarbons (paraffins and olefins). In particular, the correlation between product selectivity and varying catalyst properties and reaction parameters was studied. In-situ studies revealed that LiCoO2 was reduced to metastable Co(hcp) …
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Extruded Blend of Soybean Meal and Sunflower Seeds for Dairy Cattle in Early Lactation
… Milk from cows fed SSF contained fewer short and medium chain fatty acids, more 18-carbon fatty acids, and was more unsaturated than from cows fed SBM. Intakes of dry matter and changes in body weight were not different between diets. Ruminal fluid pH and molar ratio of acetate to propionate were …
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Characteristics of Milk and Butter from Cows Fed Sunflower Seeds
… resulted in lower concentrations of short and medium chain and higher concentrations of long chain fatty acids in milk and butter. Milk unsaturated fatty acid concentrations were (28.9, 38.8, 45.6%) and butter unsaturated fatty acid concentrations were (29.6, 38.1, 44.3%) for control, high …
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The effect of beta-oxidation or TCA cycle inhibition on mitochondrial function and the sensitivity of high resolution respiratory detection
… acid beta-oxidation (β-oxidation), particularly medium chain acyl-CoA dehydrogenase (MCAD) dysfunction is a major cause of mortality and its diagnosis is usually achieved by measuring specific protein activities or metabolites in blood and/or urine samples. However, these methods do not account …
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UNCOVERING THE MOLECULAR BASIS FOR FATTY ACID SYNTHASE PRODUCT SPECIFICITY: STRUCTURAL AND KINETIC EVALUATION OF THIOESTERASE I AND THIOESTERASE II
… enzyme solely responsible for the synthesis long chain fatty acids (LCFAs) de novo. Fatty acids, and their lipid derivatives, are critical components of all cellular biological processes, including energy storage and utilization, membrane maintenance and expansion, post-translational modification …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
… for the expression of an uncharacterized long-chain-fatty-acid acyl-CoA synthetase, CG4500, which is subject to induction by starvation. Furthermore, late L3 larvae of dERR mutants exhibit altered lipid profiles with elevated medium-chain and long-chain fatty acids. Together, with the previous …
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An exploration of lipids with the potential to influence appetite and food intake
… by a systematic review and meta-analysis on medium-chain triglycerides (MCT) was conducted. A series of three experiments followed: 1) a comparison of the satiety response to MCT and conjugated linoleic acid in individuals with healthy weight or overweight and obesity, 2) the combination of …
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