Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 151 for “"mediation analysis"”.
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Problems in high-dimensional mediation analysis
A mediation model seeks to identify and explain the mechanism of the direct and indirect effects of an exposure variable on an outcome variable, potentially mediated through several intervening variables. Statistical methods for mediation analysis are well-developed when the number of mediator …
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High-dimensional Mediation Analysis of Multi-Omics Data
… as the methylome, transcriptome, and metabolome. Mediation analysis is a useful tool for investigating the role of potentially high-dimensional intermediate phenotypes in the relationship between environmental exposures and health outcomes. Rapid development of high-throughput technologies have …
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Bayesian Balance Regression And Mediation Analysis For Microbiome Compositional Data
… is com- positional with a unit sum constraint. Analysis of compositional data requires special statistical treatment to account for the intrinsic dependence of the components due to this constraint. Bal- ance, defined as the normalized log ratio of the geometric mean of the values for the two …
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Novel Statistical Methods for Mediation Analysis with High-dimensional Omics Mediators
<p>Mediation analysis is a widely used statistical method for examining how molecular traits, such as gene or protein expression, act as intermediaries linking an exposure to a health outcome. For example, it can help explain how smoking affects disease risk through molecular changes. The rapid …
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An evaluation of parameter estimation when using multilevel structural equation modeling for mediation analysis
… mediated effects for the “upper-level” mediation model as compared with the MMM. The following conditions were manipulated: number of clusters (G), within-cluster sample size (nj ), intra-class correlation, measurement error in the mediator, and the true value of the mediated effect …
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Mediation analysis for different types of Causal questions: Effect of Cause and Cause of Effect
… queries from a particular perspective that is Mediation. Mediation Analysis aims to disentangle the pathway between exposure and outcome on a direct effect and an indirect effect arising from the chain exposure-mediator-outcome. In the EoC framework, if the goal is to measure the causal …
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A Bayesian approach to crossed-random-effects mediation analysis for zero-inflated mediators and binary outcomes
… the model of interest in the current study was a mediation model with crossed random effects, a zero-inflated mediator, and a binary outcome. With maximum likelihood estimation (MLE), the mediation model could not converge, which was consistent with the previous finding on analyzing CREM with MLE …
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Emotion Reactivity, Emotion Dysregulation, and Non-Suicidal Self-Injury among At-Risk Adolescents: A Multiple Mediation Analysis
… a residential facility. Furthermore, a multiple mediation model was used to test which facets of emotion dysregulation serve as the most powerful mediators between emotion reactivity and NSSI frequency. Findings and implications are discussed.</p>
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Social Context, Intrinsic Motivation, and Physical Activity In Underserved Adolescents In the Act Trial: A Mediation Analysis
… product-as-coefficients methods of estimating a mediation relationship (n = 1421, mean age 11.3 years, 54% female, 72% African American, 71% reduced lunch). Adolescents self-reported peer social support and intrinsic motivation. Multiple imputations were used to handle missing data, and BMI and …
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Acculturation-related stressors and Latino immigrant adolescent depressive symptoms: a multiple mediation analysis of stressors and resources by gender and immigrant generational status
… Stata 13.0 to simultaneously estimate multiple mediation effects. Then group comparison analyses were applied to test the group differences. The results showed significant mediating effects between acculturation-related stressors and depressive symptoms. In particular, the association between …
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HIV risk perception, actual HIV risk, sexual risk behaviours, and oral PrEP continuation at the 1-month follow-up in pregnant women not living with HIV in Cape Town, South Africa: A mediation analysis
… analysed using logistic regression models and mediation analysis to assess factors associated with oral PrEP continuation at 1-month and the extent to which HIV risk perception and actual HIV risk explain the relationship between sexual risk behaviours and oral PrEP continuation. Of the 1349 …
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Statistical Modeling Approaches For The Inference of Cancer Mechanisms
… related aims. Aim 1: We have developed a unified mediation analysis approach to identify and quantify the intermediate mechanisms underlying gene or pathway effects on clinical outcomes. The proposed mediation analysis framework is based on the causal directed acyclic graph (DAG) structure. We …
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Co-morbid cardiometabolic diseases among people living with HIV/AIDS in Cameroon
… and to evaluate the methodological approaches to mediation analysis and handling missing data in studies on CMDs in PLWH. Methods: The study utilized data from 14,279 PLWH enrolled in the Cameroon arm of the International Epidemiology Databases to Evaluate AIDS (IeDEA). Analyses comprised …
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Spirituality in American Muslim Marriages: An Investigation of Marital Sanctification, Spiritual Intimacy and Emotional Intimacy
… negative marital quality. Through a quantitative analysis, two serial mediation analyses were conducted with marital sanctification as the predictor variable, and spiritual intimacy and emotional intimacy as the mediator variables. In the first serial mediation analysis (the Positive Marital …
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Psychopathic traits in managers: Implications for employees' motivation, performance, and well-being at work
… manager autonomy support as a mediator. Simple mediation analysis showed that autonomy support was indeed a significant mediator of the relationships. Study 2 (n = 246) investigated the effect of perceived manager boldness, meanness, and disinhibition, on employee job performance. Both manager …
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The Relationship Between Authentic Leadership And Employee Resilience: The Role Of Trust As A Mediator Among Nurses In Makhado Municipality
… relationships between variables. Regression and mediation analysis were conducted using Haye’s PROCESS Model 4, to determine the direct effects and indirect effects of authentic leadership on resilience through trust. The results showed that authentic leadership is positively related to both …
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Early life adverse experiences and the effect on parenting stress and schizotypal symptoms
… and hypotheses were tested using correlation and mediation analysis. Results found that parenting stress mediated the association between attachment anxiety/avoidance and schizotypy, though parenting competence was not significant as a mediator in a parallel model. Childhood trauma was associated …
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