Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"medial temporal lobe"”.
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Medial Temporal Lobe Structure and Function
Medial Temporal Lobe Structure and Function by Meghana Sunil Karnik Doctor of Philosophy in Biology and Biomedical Sciences: Neuroscience) Washington University in St. Louis, 2009 Professor John G. Csernansky, Chairperson My main goal was to examine the relationship between brain structure and …
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Content representation in the human medial temporal lobe
… than surprise? It is well-established that the medial temporal lobe (MTL) is crucial to both processes, but the MTL is not a single homogeneous region. In fact, it is composed of several anatomically distinct subregions including hippocampus, perirhinal cortex (PRC) and parahippocampal cortex …
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Medial Temporal Lobe Structures Contribute to on -Line Processing
… extend the emerging view that structures of the medial temporal lobe contribute to the on-line processing of visual stimuli. These experiments uniquely demonstrate that the MTL is necessary for normal apprehension of even single stimuli when degraded, and for normal discrimination of even very …
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HORROR-EVOKED AROUSAL AND AMYGDALA BIAS OF THE MEDIAL TEMPORAL LOBE
… arousal either enhances or disrupts temporal order memory (Cliver et al., 2024; Gregory & Murty, n.d.). In both behavioral (Study 1 and Study 2) and neuroimaging (Study 2) analyses to investigate the relationship between threat-related neural circuitry during encoding of short movie …
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Medial temporal lobe and prefrontal cortex contributions to memory expressed on short timescales
… to guide adaptive behavior in the moment. The medial temporal lobe (MTL) is critical for human memory. Its role in memory at long delays is well-established, while its contribution to memory at short delays had not been appreciated until recently, when studies specifically targeted the kind of …
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Beyond Episodic Memory: Medial Temporal Lobe Contributions to Problem-solving and Semantic Fluency Tasks
… of episodic memory processes supported by the medial temporal lobes (MTL) to two goal-oriented non-episodic tasks, problem solving and semantic retrieval (verbal fluency). The reported experiments provide evidence for the hypothesis that MTL-based episodic processes are robustly involved in …
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Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models
This dissertation investigates the mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation is a theoretical mechanism involving the transformation of inputs into output representations that …
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Characterizing Medial Temporal Lobe Neurodegeneration Due To Tau Pathology In Alzheimer's Disease Using Postmortem Imaging
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). Using in vivo structural magnetic resonance image (MRI) analysis, volumetric change in the MTL caused …
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Cognitive neuroscience methodologies provide insight into medial temporal lobe contributions to perception, language, and creativity
The functional contribution of medial temporal lobe has been studied in the human brain for over half a century. Insight into the nature of this extraordinary structure was discovered when epileptic patient H.M. had an experimental operation to surgically resect his bilateral medial temporal lobes. …
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Medial Temporal Lobe Does Not Tell The Whole Story: Episodic Memory In ‘atypical’ Variants Of Alzheimer’s Disease
… of a particular event in spatial and temporal context, is the most prominent deficit in the early stage of clinical amnestic AD, and reflected by the shrinkage of structures in medial temporal lobe (MTL), including the hippocampus. According to Braak staging, tangles begin in the …
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Functional dissociation between the hippocampal formation and perirhinal cortex : evidence for independent memory systems in the medial temporal lobe
… the functional organization of memory in the medial temporal lobe of the mammalian brain suggest that the hippocampal formation (HPC) and the perirhinal cortex (PRh) are serial components in a unitary memory system. Contradictory to this view, evidence from numerous studies with monkeys and …
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Distinguishing Medial Temporal Lobe and Prefrontal Cortex Contributions to Approach-Avoidance Conflict in Healthy Controls and Generalized Anxiety Disorder: Insights from Functional Magnetic Resonance Imaging and the Hierarchical Drift Diffusion Model
… by a network of brain regions including the medial temporal lobe (MTL), striatum, and prefrontal cortex (PFC). This work, however, is limited in two respects. (1) Human models employing functional Magnetic Resonance Imaging (fMRI) have historically relied on analyses that fail to disentangle …
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How does context variability affect representational pattern similarity to support subsequent item memory?
… across a lifetime. These records are encoded via medial temporal lobe structures in the brain, including the hippocampus, and are commonly called "representations" or "memory traces". Existing studies indicate that information about the neural signal corresponding to a memory representation can be …
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The Medial Entorhinal Cortex's role in temporal and working memory : characterization of a mouse lacking synaptic transmission in Medial Entorhinal Cortex Layer III
… association of multiple input streams within the medial temporal lobe. Understanding the role each neuronal circuit and projection plays in learning and memory is essential to understanding how declarative and episodic-like memories are formed. This work here addresses the role of the medial …
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THE CONTRIBUTION OF PHYSICAL ACTIVITY TO NEUROIMAGING INDICES AND COGNITIVE FUNCTION IN HEART FAILURE
… (i.e. white matter hyperintensities (WMH) and medial temporal lobe atrophy (MTA)) mediate the relationship between physical activity and cognitive function in persons with HF. Eight-five HF patients completed a brief neuropsychological battery, brain magnetic resonance imaging (MRI), objective …
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Replay of memories of extended behavior in the rat hippocampus
… is a highly conserved structure in the medial temporal lobe of the brain that is known to be critical for spatial learning in rodents, and spatial and episodic memory in humans. During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences …
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Alpha thalamocortical networks during propofol general anesthesia and disorders of consciousness
… found that propofol anesthesia induces alpha in medial regions of the frontal cortex and the medial temporal lobe after loss of consciousness. The cortical source of propofol-induced alpha is structurally connected to the mediodorsal nucleus of the anterior thalamus, whereas regions that generate …
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Dissociable Influence of Reward and Punishment Motivation on Declarative Memory Encoding and its Underlying Neurophysiology
… engaged distinct neuromodulatory systems and medial temporal lobe (MTL) targets during encoding. Specifically, results indicated that reward motivation supports interactions between the ventral tegmental area and the hippocampus, whereas, punishment motivation supports interactions between the …
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Characterizing Cortex-Hippocampus Interactions During Language Processing
The role of medial temporal lobe structures, including that of the hippocampus, in language processing, remain largely unknown. In patients with hippocampal damage, language is left largely intact [Vargha-Khadem et al., 1997], suggesting that the hippocampus is likely not necessary for language …
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Functional Connectivity of Entorhinal Cortex in Alzheimer's Disease
… (EC) is a region of cortical gray matter in the medial temporal lobe important in memory processing, and has been identified as the first structure affected in AD. The current study investigated the functional connectivity of the EC in AD and normal control (NC) subjects using functional …
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