Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"medial prefrontal cortex"”.
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Role of rat medial prefrontal cortex in time interval estimation
… lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to test the requirement of intact medial prefrontal …
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Impact of Acute Ethanol Injections on Medial Prefrontal Cortex Neural Activity
The medial prefrontal cortex (mPFC) is a cortical brain region involved in the evaluation and selection of motivationally relevant outcomes. mPFC-mediated cognitive functions are impaired following acute alcohol exposure. In rodent models, ethanol (EtOH) doses as low as 0.75 g/kg yield deficits in …
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Regulating the anterior medial prefrontal cortex : exploratory investigation of real-time fMRI training
… regarding the level of activation in rostromedial prefrontal cortex (rMPFC) to learn improved regulation of this brain area was examined in a group of 5 young adults. Subjects received real-time feedback from the target brain region while engaging in a blocked-design task involving …
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Structure of the Rat Medial Prefrontal Cortex Is Influenced by Sex Across the Lifespan
The development and aging of sex differences in the volume, neuron number and glial cell number in the mPFC, as well as frontal white matter volume, were also examined in both sexes using unbiased stereological techniques. Ventral rat mPFC gray matter volume increased prior to puberty and then …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating …
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Contributions Of the Human Medial Prefrontal Cortex To Associative Recognition Memory: Evidence From Functional Neuroimaging
… have predominantly focused their attention on medial temporal lobe (MTL). There is growing acknowledgement however, from the cognitive neuroscience of memory literature, that regions outside the MTL can support episodic memory processes. The medial prefrontal cortex is one such region garnering …
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Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex
… of maturation for the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing …
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Long-range synchrony between medial prefrontal cortex, thalamus and hippocampus underlies working memory behavior in mice.
… that are implicated in this behavior: the medial prefrontal cortex (mPFC), the hippocampus (HPC) and the medial dorsal thalamus (MD). Lesion and electrophysiological studies in each structure have demonstrated their importance during working memory behavior. Disconnection studies also show …
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Effect of medial prefrontal cortex 6-OHDA lesions on behavioral and neurochemical responses to gustatory stimuli
… accumbens (NAc) shell and core and in the medial prefrontal cortex (mPFC) in relation to their motivational valence, salience and novelty; the DA increase in the NAc shell is subjected to single trial habituation while in the NAc core and in the mPFC is not. Recently it was shown that …
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The role of puberty in the development of the adolescent rodent medial prefrontal cortex and behavior
… as well, suggesting that the adolescent cortex is increasingly plastic. One of the most notable of these changes is the development of the prefrontal cortex (PFC), a brain region involved in higher-order cognition and mediating social behaviors. Neuronal changes that occur in this region …
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The Role of Glutamate in the Medial Prefrontal Cortex in the Acquistion and Expression of Conditioned Approach
… in the dorsal and ventral regions of the medial prefrontal cortex (mPFC) in both the acquisition and expression of reward-related learning using a Pavlovian conditioning paradigm, the conditioned-approach paradigm. Rats with surgically implanted cannulas were exposed to Pavlovian …
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The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors
… for complex cognition. The human frontal cortex and striatum are involved with working memory; however, the mechanisms through which these structures contribute to working memory are incompletely understood. Given the similarities between cortical and striatal areas in the human and rodent …
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Sex differences in the effects of two-hit stress on the structure and function of rat medial prefrontal cortex
… disorders, including mood and anxiety disorders. Prefrontal cortex dysfunction likely contributes to the cognitive symptoms associated with these disorders. Notably, women are at an increased risk for many stress-related disorders, although the neurobiological mechanisms underlying this enhanced …
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Perinatal high-fat diet and Bisphenol A: effects on behavior, gene expression and neuroanatomy in the medial prefrontal cortex
… social recognition in adulthood. Further, the cortex was collected in adulthood to assess gene expression, and the number of neurons, glia, synapses and microglia. Significant alterations were found in maternal care, inflammatory markers, gene expression, play behavior and the elevated plus …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… of anxiety and depression disorders, namely the medial prefrontal cortex (mPFC) and hippocampus (HC). To address this hypothesis, we employed a pharmacological mouse model in which serotonin levels were increased using a selective serotonin reuptake inhibitor, fluoxetine (FLX), during a …
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Phase-locking of neurons in the hippocampus and the medial prefrontal cortex of the rat to the hippocampal theta rhythm
… relationships between neuronal activity in the medial prefrontal cortex of freely behaving rats and the hippocampal theta rhythm. We demonstrate that a significant portion of prefrontal neurons are phase-locked to the hippocampal theta rhythm and we compare the phase-locking properties of …
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