Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"mechanosensor"”.
-
The nanomechanics of polycystin-1: A kidney mechanosensor
… available evidence suggests that PC1 acts as a mechanosensor, receiving signals from the primary cilia, neighboring cells, and extracellular matrix. PC1 is a large membrane protein that has a long N-terminal extracellular region (about 3000 aa) with a multimodular structure including sixteen …
-
α7β1 integrin regulation of skeletal muscle growth in response to mechanical loading
The α7β1 integrin has been proposed to serve as a mechanosensor and essential regulator of myofiber remodeling given its localization at the membrane and primary role in adhering the outer extracellular matrix to the inner actin cytoskeleton. However, additional work is necessary to affirm a …
-
Funktionelle Interaktion von Polycystin 2 und TRPV4
… Zusammenwirken der beiden Proteine als Osmo- und Mechanosensor in der Niere hin. Das Auftreten eines Harnkonzentrierungsdefekts sowohl bei TRPV4 als auch bei PKD2 defizienten Mäusen sowie bei ADPKD Patienten, zeigt die mögliche Bedeutung eines heteromultimeren TRPV4-Polycystin 2 Kanalkomplexes in …
-
Vagal Integration of Cardiopulmonary Regulation
… on SAR behaviour, consistent with minimal NEB-mechanosensor interactions. To address the later, I applied in vivo HRV analysis to assess autonomic (ANS) control in the development of murine airway hyperresponsiveness. Sensitization decreased HRV prior and subsequent to antigen challenge, …
-
α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
The α7β1 integrin has been proposed to serve as a mechanosensor and essential regulator of myofiber remodeling given its localization at the membrane and primary role in adhering the outer extracellular matrix to the inner actin cytoskeleton. However, additional work is necessary to affirm a …
-
Probing the assembly of the <em>Bacillus subtilis</em> flagellum and its role in signal transduction.
… subtilis </em>flagellum therefore acts as a mechanosensor to control the DegS-DegU two component system. Collectively, the work presented here contributes to our understanding of how <em>B. subtilis</em> regulates flagellar assembly, and further enhances our knowledge of how bacteria are able …
-
Systems biology of endothelial mechano-activated pathways
… of components of the endothelial glycocalyx, a mechanosensor that regulates shear-stressdependent NO production. Nitric oxide produced by vascular endothelial cells is an anti-inflammatory mediator and a potent vasodilator. In order to understand the rich diversity of responses observed …
-
Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells
… indicate for the first time that HSPG is a mechanosensor mediating shear stress-induced EC differentiation from ESC-derived EC cells</p> <p>As the fetal heart begins to beat, the vasculature starts to experience cyclic strain (CS) and associated stress in addition to shear stress. While …
-
Mathematical modelling of motility regulation in Myxococcus xanthus
… machinery of M. xanthus potentially serves as a 'mechanosensor' that transduces mechanical cues in the environment into a reversal modulation signal. Chapter 3 addresses a puzzling observation: cells with A-motility alone (A+S−) show a dependence of reversal frequency on substrate stiffness that …
-
Elastic interactions of cellular force patterns
… an Zell-Matrix-Kontakten übertragen, die als Mechanosensoren fungieren. Jüngste Experimente mit Zellen auf elastischen Substraten zeigen, dass Zellen sehr empfindlich auf Veränderungen der effektiven Steifigkeit ihrer Umgebung reagieren, die zu einer Reorganisation des Zytoskeletts führen …