Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"mechanoresponsive"”.
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Shockwave energy dissipation by mechanoresponsive materials
… nano-scale structural changes observed from the mechanoresponsive materials in this dissertation provide new insights for the development of efficient shockwave absorption materials that prevent traumatic brain injuries. The nano-scale heterogeneous structure consisting of two different phases is …
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Application and Development of Mechanoresponsive Polymer Structures
Mechanoresponsive Systeme antworten auf mechanische Reize mit einer Eigenschaftsänderung. Diese Dissertation umfasst die Arbeiten mit zwei mechanoresponsiven Systemen, die optisch auf mechanische Reize antworten. Sie basieren auf polymeren Strukturen, einer Polymerbürste und einem Hydrogelnetzwerk. …
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Design and synthesis of mechanoresponsive materials and multivalent polymer-peptide conjugates
Functional polymers have been studied extensively due to their versatility and ability to yield diverse materials with desirable properties. Polymers that are functionalized intrinsically are made using several strategies including specially designed monomers and post polymerization …
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Direct Measurements of Polyelectrolyte Brush Responses using Atomic Force and Optical Microscopy
… provided for the research on polymer brushes, mechanoresponsive systems, force sensing, and active materials, as well as contact mechanics, colloidal arrangement, and (bio) adhesion. In particular, the soft colloidal probe (SCP) force spectroscopy has been developed. This technique improves …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… enhances the expression of numerous mechanoresponsive cytokines and chemokines to levels exceeding what is achievable by modulating matrix stiffness alone. Taken together, these findings reveal previously unexplored mechanisms of mechanotransduction that inform novel strategies for …
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Mechanophore activation at heterointerface and surface crowdedness as a determining factor
… interfaces and thus allow design of mechanoresponsive composite materials. Our efforts in developing a thermally and mechanically triggerable ruthenium catalyst system for material remodeling application were also discussed."
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Polymer architecture effects on mechanochemical reactions
… and allow us to design increasingly sensitive mechanoresponsive polymers. Furthermore, heterogenous polymer architecuture was examined by introducing a spiropyran mechanophore at the interface of a glass fiber and PMMA matrix. Interfacial shear forces are applied to the mechanophore by a single …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… tissues, is not well studied. Adipocytes are mechanoresponsive and affected by different microenvironmental cues, including hypoxia and mechanical (un)loading. Yet, no study has focused on the role of the aforementioned factors on the adipocyte mechanical response, including actin cytoskeletal …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
… of CD28 activation, CD28 is determined to be a mechanoresponsive receptor that is not directly responsible for mechanosensitivty. Rather, CD28 mediates a change in cellular forces through PI3 kinase, whose inhibition normalizes force generation in T cells activated by TCR and those costimulated …
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INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… density and rigidity, leading cells to mount a mechanoresponsive transcription program. This work could provide i) a mechanistic understanding of MYRF in the regulation of ER activity. Considering the impact of ER stress on cancer cell fitness and drug-induced toxicity, the possibility to …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… in ovulating follicles, observed activation of mechanoresponsive element Yap1 at the follicle base and identified a gain in migratory capacity in granulosa cells. Concurrently, the basal granulosa cell layer thickened immediately prior to ovulation. Each of these events was PGR-dependent. This …
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Molecular tailoring of interfaces for thin film on substrate systems
… PS samples failed to result in SP activation. Mechanoresponsive coatings have potential to indicate deformation under shockwave loading conditions. In addition to SP-linked polymer films, the activation of spiropyran interfacial molecules with different side groups is characterized as they …
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Multiscale characterization of mechanochemical reactions in mechanophore-crosslinked polymers under shear loading
… response to polymeric materials. These mechanoresponsive materials possess the ability to respond to an applied global force through a local chemical reaction. In synthetic polymers, mechanochemical response is achieved through the use of a mechanophore, a single molecule with a …
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A quantitative and predictive model for mechanochemical kinetics and its experimental validation
… mechanochemistry offers for the design of novel mechanoresponsive and actuating materials requires a clear conceptual framework describing how and why mechanical force affects chemical reactivity. This work describes the development of such a model for mechanochemical kinetics and its …
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Molecular and Cellular Mechanisms of LIM Protein Mechanotransduction
… families of tandem LIM domain proteins to be mechanoresponsive cytoskeletal proteins. A single conserved phenylalanine in each LIM domain was identified to be necessary for mechanosensitivity. Through development of an in vitro force reconstitution system, we discovered that LIM proteins are …