Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"mechanistic modeling"”.
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Mechanistic modeling of complex microbial communities
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Mechanistic modeling of bacterial nutrient uptake strategies
… bacteria into microscale robots. Here I use toy, mechanistic models of single-cell metabolism that allow me to quantify the costs and benefits of various nutrient uptake strategies. I find that: (i) a sensing-uptake trade-off governs E. coli's regulation of maltose uptake and chemotaxis to …
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Data-driven Mechanistic Modeling of 3D Human Genome
… and cell functionality. Computational modeling serves as an efficient and effective way of building high-resolution 3D genome structures and improving our understanding of these molecular processes. My PhD research has been focused on the development of a data-driven, mechanistic …
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Mechanistic Modeling of Biodiesel Production via Heterogeneous Catalysis
Biodiesel has emerged as a promising renewable and clean energy alternative to petrodiesel. While biodiesel has traditionally been prepared through homogeneous basic catalysis, heterogeneous acid catalysis has been investigated recently due to its ability to convert cheaper but high free fatty acid …
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Mechanistic Modeling, Design, and Optimization of Low Salinity Waterflooding
… this thesis introduces one of the first mechanistic LSW models that can be used to design LSW process and interpret its laboratory and field-scale performances. A comprehensive ion-exchange model, fully coupled with geochemistry specially designed for the modeling of LSW physical …
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Transcriptional regulatory genomics: from mechanistic modeling to causal inference
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Mechanistic Modeling of Nuclear Waste Form Leaching by Aqueous Solutions
Predictive modeling of nuclear waste form leaching requires a mechanistic representation of the processes and factors controlling the rates at which species are released from the solid waste form into the contacting aqueous solution. A basic distinction is made among bulk, surface, and leachant …
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Integrating statistical and mechanistic modeling to analyze disease omic data
Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2013-10-30T20:45:53Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 WANG_YULIANG.docx: 2952821 bytes, checksum: 08c2e350ebf29e4a14805992d55ba80f (MD5) WANG_YULIANG.pdf: 3382980 bytes, …
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Mechanistic modeling of increased oxygen transport using functionalized magnetic fluids in bioreactors
Absorption of gases into a liquid is of crucial importance to multiphase reactions because diffusion of a sparingly soluble gas across a gas-liquid interface generally limits the relevant reaction rates. Pertinent examples of multiphase reactions that have found application in the chemical and …
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Linear and non-linear mechanistic modeling and simulation of the formation of carbon adsorbents
… This work aims at probabilistic analysis, modeling, and simulation of the formation of carbon adsorbents on the basis of mechanistic rate expressions. Specifically, the current work has formulated a set of linear and non-linear models of varied complexity; derived the governing equations of …
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Mechanistic modeling of alpha-synuclein aggregation and brain pharmacokinetics for drug development in neurodegeneration
Mechanistic modeling plays an increasingly important role in central nervous system (CNS) drug development, but its impact depends on how well models reflect the underlying biology and account for the limitations of available data. This thesis addresses these challenges through two distinct yet …
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Mechanistic modeling and systems analysis across biological scales, from single cells and regulatory networks to microbial communities
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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The hydrology of malaria : field observations and mechanistic modeling of the malaria transmission response to environmental climatic variability
… determinants of malaria transmission mechanistically and at high spatialand temporal resolution, and is valid for semi-arid, desert fringe environments where the mosquito Anopheles gambiae s.l. is the dominant malaria vector. This includes much of the most malarious parts of Africa …
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Mechanistic modeling of cutting forces in wavy-edge bull-nose helical end-milling of Inconel 718 under different cooling-lubrication strategies
… presents the results of the development of a mechanistic cutting force prediction model for the wavy-edge bull-nose helical endmill (WEBNHE). The mechanistic model was developed to predict cutting force components and the resultant cutting force in high-speed end-milling of Inconel 718 under …
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Towards extending coarse-grained circuit-host modeling to complex environments
… environments. Recent advances have shown that a mechanistic, coarse-grained approach can give fundamental insight into how synthetic circuits interact with their host cells, though how this model can be applied in complex environments remains an open question. In this thesis, I will discuss how …
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Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract
… as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops …
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An Assessment and Modeling of Copper Plumbing pipe Failures due to Pinhole Leaks
… ages. Due to the absence of a single acceptable mechanistic theory no preventive measure is available to date. Most of the present mechanistic theories are based on analysis of failed pipe samples however an objective comparison with other pipes that did not fail is seldom made. The variability …
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Multiscale Modeling and Mechanistic Analysis of Crystallization and Particulate Processes
… molecular dynamics simulations, microkinetic modeling, and population balance modeling are used to investigate crystallization phenomena across molecular, mesoscale, and continuum scales. We observed that antisolvent crystallization and oiling-out are governed by disruption of hydration shells …
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Uncovering Perovskite Degradation Equations Using Scientific Machine Learning
… ML — a blend of traditional scientific mechanistic modeling (differential equations) with machine learning methodologies — to identify differential equations governing the degradation of methylammonium lead iodide perovskite (MAPI), a material with known instability under environmental …
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