Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 58 for “"mechanistic explanation"”.
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Emergence and experience: systemic emergence and the prospects for a mechanistic explanation of the existence of experience
… are real, causally potent, and in need of explanation. This thesis will work towards their reconciliation. I develop and defend a conception of emergence—emergence as systemic novelty—that is in keeping with discussions in systems biology and the other sciences of the mind. This picture …
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The Manipulated Mechanism: Towards an Account of the Experimental Discovery of Mechanistic Explanations
… of biology has sought after an account of mechanistic explanation. Biologists frequently encounter causal relationships that beg for explanation. For example, genes appear to encode for particular phenotypes. How does gene expression work? Biologists posit mechanisms to explain the link …
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A NOVEL PRO-OXIDANT ROLE OF GELSOLIN IN CANCER CELL INVASION
… The impairment of Cu/Zn SOD activity provides a mechanistic explanation for the elevated amount of intracellular O2- in gelsolin-overexpressing cells. Therefore, our findings demonstrate a new insight into the role of gelsolin in cancer cell invasion through upregulation of O2- levels.
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Reaction calorimetry applied to kinetic problems. The design and construction of an isothermal calorimeter with heat compensation by the Peltier effect, and the application of the calorimeter in the study of reaction kinetics in solvent/water mixtures.
… in the reaction mechanism has been examined. A mechanistic explanation has been proposed in order to correlate the rate of reaction with the composition of water-solvent mixtures which justifies the Laidler and Eyring treatment of solvent effects on ion-molecule reactions.
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… of BRCA1 to the ER. These findings provide a mechanistic explanation by which BRCA1 can act as a pro-apoptotic protein.
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14-3-3Sigma Negatively Regulates The Stability and Subcellular Localization of Cop1
… regulation of COP1 upon DNA damage and provide a mechanistic explanation of the correlation of COP1 overexpression with 14-3-3σ downregulation during tumorigenesis.
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Modeling Evolutionary Constraints and Improving Multiple Sequence Alignments using Residue Couplings
… amino acid combinations, which do not yield a mechanistic explanation. Most of these methods primarily use a multiple protein sequence alignment---most likely a resultant alignment---which better exposes couplings and is obtained through manual tweaking of an alignment constructed by a …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… for intracellular growth. My findings provide a mechanistic explanation for the clinical tuberculosis treatment data gathered over the last 50 years where the length of treatment required for cure correlates with bacterial burdens. Moreover, the addition of the calcium channel blocker, verapamil …
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Exploring middle school students' sensemaking of a gesture-augmented computer simulation depicting thermal conduction
… computer simulation to develop a causal-mechanistic explanation of thermal conduction through a silver spoon. The computer simulation is a dynamic molecular model of a spoon that depicts the causal-mechanism of the spoon’s molecules moving to explain how heat transfer occurs. Moreover, it …
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Understanding the functional consequences of genetic variation on gene regulation
… in a context aware manner and provide mechanistic explanation of the gene regulatory processes. In this thesis, we aspire to provide tools for understanding sequence-level encoding of gene regulation by applying thermodynamics-based models. More specifically, we provide a probabilistic …
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Forest Net Primary Production Resistance Across a Gradient of Moderate Disturbance
… and leaf area loss. These findings provide a mechanistic explanation for sustained ANPPw across the disturbance gradient, in which the physiological and growth enhancement of undisturbed vegetation was proportional to the level of disturbance severity. Our results have important ecological and …
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Basolateral Aamygdala circuits for differentiating positive and negative associations
… within these circuit components and provides a mechanistic explanation, on synaptic, cellular, circuit and molecular levels, for how positive and negative associations can be formed within, and diverge from the BLA.
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Durability of Chopped FiberReinforced Polymeric Composites for use in Experimental Automotive Fuel Cells
… in material properties as great as 25% to 75%. A mechanistic explanation was developed for the formation of blisters in the epoxy composite. Recommendations for material improvement and feasibility of material use for fuel cell manifolds and pressure plates were made.
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Antimicrobial Peptides Activity and Efficacy Prediction by Stochastic Models and Machine Learning Methods
… types of AMP operate more optimally, offering a mechanistic explanation of the bacterial clearance dynamics and AMP cooperativity mechanisms. Increasing the number of AMP components in a mixture while keeping the total amount fixed enhances their synergistic activities, and strong cooperativity …
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Regulation of Micrornas by 17β-Estradiol in the Aging Female Brain
… These data suggest that miRNAs could be a mechanistic explanation for the observed altered efficacy of HT in post-menopausal women.</p>
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… showed decreased proliferation. A possible mechanistic explanation for reduced proliferation and selective reduction of P-Erk levels in the N51-FLT3-Y768-expressing cells is through decreased recruitment of Grb2, which participates with son of sevenless, SOS, to activate the RAS-Erk …
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Yeast Ataxin-2 (Pbp1) Condensates Regulate TORC1 Activity and Autophagy in Response to Cellular Redox State
… TORC1 signaling. These observations offer a mechanistic explanation describing how reversible formation of condensates formed from the LC region of Pbp1 has evolved as a sensor of cellular redox state.
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… by ATM. Taken together, our study provides a mechanistic explanation of decreased innate immune response associated with A-T mutation.
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Contrast sensitivity and emotion recognition across the menstrual cycle
… account, one of which is the lack of a mechanistic explanation of such changes in female perception. In a novel approach to investigating candidate mechanisms of this cyclic variation, experiment 1 measured contrast sensitivity across the menstrual cycles of naturally cycling women and …
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Mathematical Modelling of Immuno-Oncology and Related Immunology
… with leukemia. Our results provide a plausible mechanistic explanation for widely variable patient responses to CAR-T cell therapy seen clinically, and suggest possible ways to improve patient outcomes, even and especially when the patient population is highly heterogeneous. In particular, our …
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