Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 343 for “"mechanisms of action"”.
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Mechanisms of Action in Motivational Interviewing
Despite the demonstrated efficacy of disease modifying therapies (DMT), many MS patients (~ 40%) stop using DMT within 3 years of starting. A cross-over randomized controlled trial demonstrated that a theoretically based motivational interviewing- cognitive behavior therapy (MI-CBT) intervention …
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Mechanisms of Action of Sulphur Containing Antioxidants
The thesis deals with the antioxidant chemistry of two classes of sulphur-containing antioxidants. Part A is concerned with the sulphoxide dimethylsulphinyldipropionate (DMSD) and its reaction with hydroperoxide. Its activity as a peroxide decomposer is explained in terms of catalytic activity of …
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Plant natriuretic peptides - elucidation of the mechanisms of action
Several lines of cellular and physiological evidence have suggested the presence of a novel class of systemically mobile plant molecules that are recognized by antibodies generated against vertebrate atrial natriuretic peptides (ANPs). Functional characterization of these immunoanalogues, referred …
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Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
… unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad range of activity of CpG ODN makes it a promising …
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Investigating the mechanisms of action of the SNF2-homolog protein Fun30
In eukaryotes, the manipulation of chromatin structure represents a means of regulating access to genetic information. One way in which this can be achieved is via the action of ATP-dependent chromatin remodelling complexes related to the S.cerevisiae Snf2 proteins. The Fun30 protein (Function …
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Comparitive activities and mechanisms of action of three novel antiulcer agents
Antiulcer agents, notably inhibitors of gastric acid secretion, have been the most successful category of drugs to be discovered in recent years; and moreover, there are currently four such agents in the world list of top 25 best selling drugs. Histamine H2 antagonists have been the number one …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
Chemotherapy for the treatment of systemic cancer originated over half a century ago. Thus, many of our most successful therapies were implemented clinically without the wealth of molecular and genetic knowledge we have today. Other than empirically determined survival benefit, another primary …
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Studies on the mechanisms of action of the herbicide safener CGA- 92194
… The potential adverse phytotoxic effects and the mechanisms of the protective action of this safener were studied in laboratory experiments. Adverse phytotoxicity was assessed by comparing CGA-92194 and the herbicide safeners cyometrinil {(Z)-α[(cyanomethoxy)imino]benzeneacetonitrile} and …
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Evaluation of anti-ageing potential of lemongrass tea and its mechanisms of action
Submitted in fulfilment of the academic requirement for the degree of Doctor of Philosophy in Food Science and Technology, Durban University of Technology, Durban, South Africa, 2025.
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
INTRODUCTION: The focus of this MD thesis has been relaxin, a member of the insulin family, which is a protein composed of two disulphide linked chains of approximately 6000 Daltons. Relaxin has been traditionally recognised as a hormone of parturition, though more recently it has been postulated …
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Elucidating the mechanisms of action and evolutionary relationships of phage anti-defence proteins
… evolutionary arms race, driving the emergence of diverse bacterial defence systems that protect bacteria against phages, and corresponding phage-encoded anti-defence proteins (ADPs) that overcome these systems. Understanding the mechanisms of this co-evolutionary dynamic has had profound …
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Mechanisms of action and selectivity of the cyclohexen-one herbicide cycloxydim (BAS 517)
The activity and the selectivity of cycloxydim {2-[1-(ethoxyimino)butylJ-3-hydroxy- 5-(2H-tetrahydrothiopyran-3-yl)-2-cyclohexen-l-one}, code designation BAS 517, were examined flIst with etiolated seedlings of com (Zea mays L.) and soybean [Glycine max (L.) Merr.]. Etiolated soybean seedlings were …
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Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line
… was carried out in order to gain insights into mechanisms of halogenated aromatic hydrocarbon (HAH) toxicity. The results improve our ability to characterize the risks posed by HAH exposure as well as further demonstrate the application of cultured cells to questions of AHR function. Cell …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets …
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Treatment Matching in PTSD: A Confirmatory Factor Analysis Based On Therapeutic Mechanisms of Action
… from PTSD. Along with the more overt symptoms of PTSD (e.g., persistent hyperarousal), secondary cognitive symptoms have also been shown to be significantly associated with avoidance and intrusive symptoms, as well as contribute to functional impairment. Based on the factor analytic and …
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Studies on the mechanisms of action of the male specific lethal complex in Drosophila
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Dosage compensation is achieved by a twofold up-regulation of the single X chromosome in male Drosophila. The inverse dosage effect produced by the single dose of the X chromosome increases the expression of the X chromosome and …
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p,p' DDE Regulated Gene Expression and Possible Mechanisms of Action in Breast Tumor
… due to its environmental persistence, levels of bioaccumulation in breast adipose tissue, and endocrine disrupting actions. Epidemiological studies have had inconsistent findings, however a study in MMTV-neu mice determined that localized, developmental exposure to the reported anti-androgen …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
… auxiliary alpha2delta, beta and gamma subunits. Of the three auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium currents regulate rhythmic activity and cell proliferation in the heart. …
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Mechanisms of action and inhibition of [4Fe-4S] proteins IspG and IspH in isoprenoid biosynthesis
… (also known as the non-mevalonate pathway) of isoprenoid biosynthesis is potentially an important anti-bacterial and anti-malarial drug target. However, the catalytic mechanisms of the last two enzymes in this pathway, IspG (also known as GcpE) and IspH (also known as LytB) were largely …
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