Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"mechanical stimulation"”.
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Frequency response of human skin in vivo to mechanical stimulation
… response of human skin was measured, in vivo, to mechanical stimulation at a scale useful in the development of tactile displays. Sinusoidal vibration stimuli of varying frequencies and amplitudes were applied with a flat-ended 0.5 mm diameter cylindrical probe under two conditions: it was either …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
… to positive adaptations in skeletal muscle with mechanical stimulation. In Aim 2, WT and α7Tg mice were subjected to myotenectomy (MTE) of the gastrocnemius muscles and subsequent chronic mechanical loading (CML) for 1 day (1D) or 14 days (14D). The results suggest that the α7β1 integrin augments …
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Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling
… area of interest is in understanding how mechanical stimuli protects the formation of bone, leading to improved bone quality. Initially, this area was explored through use of tibial loading in a disease mouse model (osteolathyrism, induced by injection of beta-aminoproprionitrile) as a …
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Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
Mechanical stimulation of 3-D chondrocyte cultures increases extracellular matrix (ECM) production and mechanical stiffness in regenerating cartilage. The goal of this study was to examine the progression of chondrocyte signaling responses to mechanical stimulation in 3-D culture during tissue …
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Bone biomaterial engineering. Modification of cell and tissue response by mechanical stimulation and biomaterial nanostructure
Contains fulltext : 118073.pdf (Publisher’s version ) (Open Access)
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Effects of biochemical and mechanical stimulation of articular chondrocytes in collagen-GAG scaffolds : extracellular matrix biosynthesis and scaffold stiffness
… behavior: chemical growth factors and mechanical loading. In chapter 2, FGF-2, a chemical regulator, was supplied to chondrocyte-seeded constructs over a 4 week culture period. Afterward, these constructs were subjected to sequential ramp and hold compressive strains on a Dynastat …
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Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation.
… are known to interact and respond to external mechanical cues and recent work has shown that application of mechanical stimulation, delivered via acoustic vibration, can be used to control complex cell behaviours. Much of the work in this area has focused on the effects of mechanical …
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An electromechanical system for characterization of piezoelectric materials
… unique characteristics, which is to respond to mechanical stimulation by producing an electrical current and vice versa. They perform a pivotal role in medical applications both for diagnostic and therapeutic purposes. In this regard, characterizing the piezoelectric properties of these …
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Molecular mechanisms involved in cell response to mechanical forces
New devices were designed to generate a localized mechanical vibration of flexible gels where human umbilical vein endothelial cells (HUVECs) were cultured. The stimulation setups were able to apply relatively large strains (30%~50%) at high temporal frequencies (140~207 Hz) in a localized …
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Design and development of a bioreactor for ligament tissue engineering
Mechanical signals applied in-vitro to cell-scaffold construct may induce the formation of ligament-like structure having in-vivo functional properties. To explore this hypothesis, a novel bioreactor was designed to study the in vitro effect of biaxial cyclic mechanical stimulation on the adhesion, …
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Mechanically-induced intercellular remodeling of cardiomyocytes by magnetic micromanipulation
… such as hypertrophy. Understanding how local mechanical forces influence the remodeling of gap junctions can provide insight into arrhythmias and reentry circuits. In this work, I describe a system for exerting local mechanical forces on cardiomyocytes to study gap junction remodeling and I …
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The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
… investigate the role of cell communication and mechanical stimulation in a 3D tissue engineered construct, and to determine whether this construct could be optimized for bone healing. It is well established that there is an interconnected relationship between connexin-containing gap junctions, …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… of a nocifensive withdrawal response to mechanical stimulation following activation of primary trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats that were injected with CGRP alone or co-injected with inhibitors and determined changes in nocifensive behavior …
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Hypergravitational stimulation of cell differentiation
… which encapsulates cellular responses to mechanical stimuli. Mechanotransduction is the highly dynamic and varied downstream cellular signalling which is activated through many different modes of mechanical stimulation. Control of stem cell differentiation has been controlled in the past …
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A Study of the Transmission of Sensory Information in the Cat Spinal Cord
… responsive to more than one kind of cutaneous stimulation (touch and cooling for example) or whether individual fibers were specific, responding to only one kind of stimulation. If single fibers were found to be polymodal, the possibility had to be considered that stimuli related to a …
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Scleraxis-mediated regulation of tendon and ligament cell mechanobiology
… this, reinjury is common. It is well known that mechanical stimulation is beneficial for promoting tendon and ligament development and tissue homeostasis; however, the specific mechanisms remain unclear. The transcription factor scleraxis (Scx) is an interesting candidate for mediating the tendon …
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