Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"mechanical load"”.
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Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading of bones in vivo include bone formation, though it is unclear if this …
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Development, assessment and application of a novel algorithm to automatically detect change of direction movement and quantify its associated mechanical load in elite Australian Football
… the ball or movement of another player. The biomechanical loading requirements of change of direction (COD) movement are angle and velocity dependant. Cumulative COD movement can impart high levels of neuromuscular and metabolic fatigue which can adversely affect the efficiency of subsequent …
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Structural integrity assessment of engineering components under cyclic loading at high temperature
… 90° back-to-back pipe bends under cyclic thermo-mechanical load and constant pressure. Another numerical study investigates creep-cyclic plasticity behaviours of Particle Reinforced Titanium Matrix Composites (PRTMCs), which is a futuristic engineering material, subjected to a cyclic …
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Predictive Methods for the Fire Resistance of Single Skin and Sandwich Composite Materials
… composite materials<br/>subjected to fire and mechanical load. The materials that were investigated were<br/>representative of the materials used in the construction of Royal National Lifeboat<br/>Institution (RNLI) lifeboats.<br/><br/>A new method has been developed to assess the response both …
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Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
… intracellular calcium levels in response to mechanical stimuli. Recent studies have demonstrated that TRPV4 is required for the induction of extracellular gene expression in murine intervertebral disc (IVD) cells in response to mechanical load. We investigated the role of TRPV4 in age …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
<p>Mechanical load (tension, compression, strain and stress) is constantly applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor …
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The effects of force on actin-myosin ATPase activity
… reaction. We measured the effects of mechanical forces on the actin-myosin ATPase activity using a standard motility assay and analysis for skeletal and cardiac muscle myosin. A mechanical load was imposed on a sliding actin filaments using alpha-actinin, and the corresponding effects …
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Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
… to be the primary cell involved in sensing mechanical loads. The Wnt/β-catenin pathway is activated in the osteocyte upon mechanical loading. The role of estrogen (specifically estrogen loss) in regulation of this pathway in osteocytes is not fully understood. I hypothesize that estrogen is …
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Characterizing the effects of repetitive head trauma in female soccer athletes for prevention of mild traumatic brain injury
… changes in these biomarkers and the cumulative mechanical load experienced by female soccer athletes may prove valuable in developing measures to prevent mTBI. This work pairs functional magnetic resonance imaging with head impact monitoring to assess changes in cerebrovascular reactivity and …
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Quantification of Cumulative Load on the Knee using a Vibration Emission Method
… farming. Squat-lifting postures can induce heavy mechanical loads on the joint, causing the articulating surfaces to deform. This can result in changes of vibration characteristics of the joint surfaces. Differences in the vibration characteristics of normal and pathological joints have been …
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Fabrication of a Low-Cost, Motorized, 3D-Printed Mechanical Testing Device Compatible with Confocal Microscopy
Current mechanical testing approaches in bioengineering involve systems that are bulky, expensive, and unable to work in tandem with many characterization procedures. In this thesis, we report the fabrication of a 3D-printed mechanical testing device with motorized translation controllable over a …
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Simulated impact trauma and osteoarthritis: the role of cell volume and mechanotransduction
… participation in exercise, however single-impact load (e.g. trauma) and altered joint loading can cause bone fracture(s) resulting in permanent cartilage damage and increased risk of osteoarthritis (OA). This study investigated the role of single mechanical load and the effects of …
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Terminal Behavioral Modeling of Electric Machines for Real-time Emulation and System-level Analysis
… of have accurate behavior of electrical and mechanical terminals of the machine without the detailed information about the internal structure of the machine, material characteristics or topology of the machine. Instead, accurate model of electrical and mechanical terminals of the machine are …
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THE ROLE OF ACCELERATION RELATED VARIABLES FOR HAMSTRING MUSCLE (RE-) INJURY PREVENTION IN ELITE ASSOCIATION FOOTBALL
… of research were to develop new laboratorial and load monitoring strategies related to acceleration actions, by exploring biomechanical factors from a physiotherapist perspective. Additionally, implementing assessments and exposing some key limitations of these assessments in professional clubs is …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
… response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and dose-dependent increase in FAK-S910 phosphorylation in neonatal rat …
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Mechanical Processes of a Single Synthetic Molecular Machine Studied by AFM-based Force Spectroscopy
… This allows these molecular machines to perform mechanical tasks such as intracellular cargo transport or muscle contraction in plants and animals. Although some artificial molecular machines have been synthesized and used collectively to perform mechanical tasks, so far there have been no direct …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical loading
… of skeletal muscle mass in response to mechanical loading. The purpose of this study was to 1) to utilize an automated computer program (SMASH) to reassess myofiber cross-sectional area in previously collected samples, and 2) to determine the mechanism by which the α7β1 integrin can …
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Towards structural health monitoring in carbon nanotube reinforced composites
… increasingly common in industry, detecting mechanical damage and damage accumulation becomes increasingly difficult as many modes of failure occur below the external surface. Traditional SHM techniques may be time consuming and costly; however, CNTs are a unique material that shows promise …
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Scale-up of a high-technology manufacturing startup : improving product reliability through systematic failure analysis and accelerated life testing
… distribution for the accelerating stresses of mechanical load and lubrication. The work performed provides NVBOTS and similar high-technology manufacturing startups a complete starting point for systematically analyzing their product's reliability and quantitatively evaluating its life in a …
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Computer aided analysis and design of a single phase tubular induction actuator
… involving power electronics and a moving mechanical load. The power supply can be of any kind of voltage or current waveform, such as sine wave, square wave, PWM wave or phase controlled wave. The simulated results in both steady and dynamic states are found to be in very good agreement …
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