Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"mdx mouse model"”.
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Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… thesis examined mood in the dystrophin-deficient mdx mouse model of DMD and examined the effects of the tri-cyclic antidepressant, amitriptyline on behaviours. Amitriptyline had anti-depressant and anxiolytic effects in the mdx mice possibly through effects on stress factors such as …
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Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… dystrophin. Initially, we used the dystrophic mdx mouse to investigate what impact loss of dystrophin had on normal hippocampal function. Significantly, LTP, the molecular correlate of learning and memory was shown to be decreased in mdx mice, which has been linked to memory dysfunction. …
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The Effect of Resveratrol On Skeletal Muscle Function, Muscle Pathology, and Oxidative Capacity In the Mdx Mouse Model of Duchenne Muscular Dystrophy
… capacity, and utrophin protein expression in the mdx mouse model of DMD. Specific aim 1 examined the effect of resveratrol treatment on in-vivo and in-situ muscle function. Resveratrol treatment significantly increased rotarod performance, increased specific peak tension of the triceps surae …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… in the skeletal muscle of DMD patients and the mdx mouse model. Previous pharmacological and transgenic mouse studies have demonstrated that the α7β1 integrin is a major modifier of disease progression in mouse as well as the Golden retriever dog models of muscular dystrophy. Therefore, we …
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Exploring Dystrophin-Mediated Control of Neural Stem Cell Fate Associated with Intellectual Disability In Duchenne Muscular Dystrophy Patients
… on cognition. The most commonly used animal model to study DMD is the mdx mouse which completely lacks Dp427 but no other DMD isoforms. Although the muscle phenotype is well-established, behavioural characterization of the mdx mouse model has been inconclusive. In this thesis I investigated …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… affected dystrophic tissues using the mdx mouse model; from severely dystrophic diaphragm; moderately affected hind limb to naturally protected interosseus muscle were used to investigate the pathogenesis of the disease. Proteomic analysis of the muscle subtypes indicated that skeletal …
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Cross-Species Evolution of New AAV Variants
… genome editing in a fluorescent reporter mouse model. Enhanced transduction efficiency of AAV.cc47 vectors is further corroborated in macaques and pigs, providing a strong rationale for potential clinical translation into human gene therapies. Lastly, we report increased expression of a …
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The growth of murine breast cancer cells in dystrophic mice
… cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary tumors. Results: There were differences in body …
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Characterizing RyR and SERCA function in the C57 and D2 mdx mouse models of Duchenne Muscular Dystrophy
… potential differences in SR Ca2+ handling in two mouse models of DMD. The D2.B10-Dmdmdx/J (D2 mdx) mouse has emerged as a more pathologically representative model of DMD than the C57BL/10ScSn-Dmdmdx/J (C57 mdx) mouse model, showing greater muscle weakness, wasting and earlier disease onset. …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… recent evidence has shown that the DBA/2J (D2) mdx mouse model of DMD presents with cognitive dysfunction and a shift towards amyloid beta (Ab) production in the hippocampus and prefrontal cortex (PFC). However, this was not observed in the traditional, yet less severe model of DMD, the C57BL/10 …
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
A novel model of mitochondrial bioenergetic regulation has been proposed whereby microtubules may directly influence the permeability of ADP into the mitochondria to stimulate the production of ATP. Specifically, tubulin, the structural unit of microtubules, physically inserts into the voltage …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
… and concomitant structural and functional remodeling, especially Ca handling. Ca is critical in both the electrical and mechanical properties of cardiac myoctyes, and much is known about ionic currents and the normal excitation-contraction coupling process. In heart failure, distinct impaired …
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Imaging 3D tissue fiber organization using optical polarization tractography
… to image freshly excised heart samples of the mdx mouse model of Duchene muscular dystrophies (DMD). A rotational imaging platform was developed to obtain OPT images of the excised whole mouse heart. The imaging light was repetitively scanned along the long axis of the heart while the heart was …
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Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture
… potential defects in metabolism of the C57BL/10 mdx mouse model of DMD, and to determine the role of Ca2+ in any such defects. In particular, this thesis has examined the efficacy of the nutritional supplements creatine (Cr) and to a lesser extent, isolated whey protein (WP), in improving …