Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"mdx mouse"”.
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Force potentiation in the MDX mouse
… to prevent damage in Xlinked muscular dystrophy (mdx) mice since PTP increases force and PTP effects are greatest in IIB fibers. PTP experiments were performed on the extensor digitorum longus (EDL) of 50 day old mdx (YM) and C57BL/10 (YC) mice and 10 month old mdx (OM) and C57B1710 (OC) mice. …
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Leucine and exercise improve skeletal muscle function in the mdx mouse
… and exercised x-linked dystrophic mice (mdx) over 4 weeks would improve skeletal muscle function and decrease markers of skeletal muscle degradation. In sedentary mdx mice, leucine improved tetanic extensor digitorum longus (EDL) stress (p < 0.05), gastrocnemius mammalian target or …
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Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… thesis examined mood in the dystrophin-deficient mdx mouse model of DMD and examined the effects of the tri-cyclic antidepressant, amitriptyline on behaviours. Amitriptyline had anti-depressant and anxiolytic effects in the mdx mice possibly through effects on stress factors such as …
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Characterizing RyR and SERCA function in the C57 and D2 mdx mouse models of Duchenne Muscular Dystrophy
… potential differences in SR Ca2+ handling in two mouse models of DMD. The D2.B10-Dmdmdx/J (D2 mdx) mouse has emerged as a more pathologically representative model of DMD than the C57BL/10ScSn-Dmdmdx/J (C57 mdx) mouse model, showing greater muscle weakness, wasting and earlier disease onset. …
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Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… dystrophin. Initially, we used the dystrophic mdx mouse to investigate what impact loss of dystrophin had on normal hippocampal function. Significantly, LTP, the molecular correlate of learning and memory was shown to be decreased in mdx mice, which has been linked to memory dysfunction. …
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The Effect of Resveratrol On Skeletal Muscle Function, Muscle Pathology, and Oxidative Capacity In the Mdx Mouse Model of Duchenne Muscular Dystrophy
… capacity, and utrophin protein expression in the mdx mouse model of DMD. Specific aim 1 examined the effect of resveratrol treatment on in-vivo and in-situ muscle function. Resveratrol treatment significantly increased rotarod performance, increased specific peak tension of the triceps surae …
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The growth of murine breast cancer cells in dystrophic mice
… cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary tumors. Results: There were differences in body …
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Exploring Dystrophin-Mediated Control of Neural Stem Cell Fate Associated with Intellectual Disability In Duchenne Muscular Dystrophy Patients
… commonly used animal model to study DMD is the mdx mouse which completely lacks Dp427 but no other DMD isoforms. Although the muscle phenotype is well-established, behavioural characterization of the mdx mouse model has been inconclusive. In this thesis I investigated the hippocampal and …
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A biochemical and molecular analysis of functional differences between dystrophin and utrophin
… transgenic overexpression of utrophin on the mdx mouse background (Fiona-mdx) is not sufficient to rescue the disorganized microtubule network of the mdx mouse. Thus, we have elucidated a second functional difference between dystrophin and utrophin. Additionally, Fiona-mdx mice lack full …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… in the skeletal muscle of DMD patients and the mdx mouse model. Previous pharmacological and transgenic mouse studies have demonstrated that the α7β1 integrin is a major modifier of disease progression in mouse as well as the Golden retriever dog models of muscular dystrophy. Therefore, we …
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Imaging 3D tissue fiber organization using optical polarization tractography
… to image freshly excised heart samples of the mdx mouse model of Duchene muscular dystrophies (DMD). A rotational imaging platform was developed to obtain OPT images of the excised whole mouse heart. The imaging light was repetitively scanned along the long axis of the heart while the heart was …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… affected dystrophic tissues using the mdx mouse model; from severely dystrophic diaphragm; moderately affected hind limb to naturally protected interosseus muscle were used to investigate the pathogenesis of the disease. Proteomic analysis of the muscle subtypes indicated that skeletal …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… recent evidence has shown that the DBA/2J (D2) mdx mouse model of DMD presents with cognitive dysfunction and a shift towards amyloid beta (Ab) production in the hippocampus and prefrontal cortex (PFC). However, this was not observed in the traditional, yet less severe model of DMD, the C57BL/10 …
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Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development
… compared to fibrils generated in the control mouse. Murine plaques with an inflammatory phenotype, with a fibromodulin-deficient ECM, were also smaller with decreased lipid accumulation, whereas cell proliferation was increased. In addition, we show, for the first time, that high fibromodulin …
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Elucidation of Emergent Regional Mechanisms of Heart Muscle Dysfunction in the Mouse Model of Duchenne Muscular Dystrophy
… flux disturbances in the dystrophin-deficient (mdx) mouse heart. Furthermore, we elucidate abnormalities in autophagic processes that can be corrected with nanoparticle therapeutics delivering rapamycin to heart tissues to improve ventricular function in affected older mice with incipient …
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Chronic Dietary Supplementation of Branched-Chain Amino Acids Does Not Attenuate Muscle Torque Loss in a Mouse Model of Duchenne Muscular Dystrophy
… treatment. In this study, wild type (WT) and mdx animals were provided either a control or elevated branched chain amino acid (BCAA) diet nocturnally for 25 weeks to determine if the elevated BCAAs would attenuate muscle torque loss. Twenty-five weeks of chronic, elevated BCAA supplementation …
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The effect of taurine on dystrophic muscle tissue function
… performed in three studies using the dystrophic mdx mouse as a model for DMD.
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Development of a SNP Assay for the Differentiation of Allelic Variations in the mdx Dystrophic Mouse Model
… the dystrophic and wild type (wt) alleles in mdx mice. The mdx mouse is an animal model for Duchenne muscular dystrophy (DMD), a severe and fatal muscle wasting disease. To evaluate possible treatments and to carry out genetic studies, it is essential to distinguish between mice that carry the …
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Prevention of Duchenne Muscular Dystrophy by CRISPR/Cas Therapeutic Genome Editing
… correct a Dmd exon 23 nonsense mutation in mdx mouse by CRISPR/Cpf1-mediated germline editing. Furthermore, I apply CRISPR/Cas9-mediated post-natal genome editing to correct a Dmd exon 44 out-of-frame deletion mutation in a DMD mouse model. Finally, I develop an effective strategy to improve …
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Cross-Species Evolution of New AAV Variants
… genome editing in a fluorescent reporter mouse model. Enhanced transduction efficiency of AAV.cc47 vectors is further corroborated in macaques and pigs, providing a strong rationale for potential clinical translation into human gene therapies. Lastly, we report increased expression of a …
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