Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"mdx mice"”.
-
Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… signature and improve muscle function in mdx mice, a model of DMD. C57BL10 (WT) and mdx mice were fed AIN 76A diet ± 0.1% SM for 7 weeks starting at age 4 weeks (n=10/group: WT, WT + S, mdx, mdx + S). At ages 5, 7, and 9 weeks, ankle flexor torque was determined in vivo. Mice were …
-
Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
… resistance in a preclinical model for DMD, the mdx mouse. However, the exact cellular mechanisms leading to these benefits remain unknown and is the purpose of the present thesis. To this end, male muscle-specific GSK3 knockdown mice (C57BL/6J background) were bred with female homozygous D2 mdx …
-
Physiological adaptations in mdx mice treated with microdystrophin gene therapy and endurance exercise
… and in vivo plantarflexor torque output in young mdx mice, a mouse model of DMD. Although treated mice could run well, diaphragm force and power output were blunted by VWR. A subsequent study tested longevity of two different microdystrophin gene therapy constructs in combination with VWR. …
-
Potential adaptive signaling pathways in the diaphragm of mdx mice treated with micro-dystrophin combined with voluntary running
… to micro-dystrophin gene therapy (GT) in mdx mice, a model of Duchenne muscular dystrophy (DMD). After 21 weeks of running, time to fatigue on a treadmill for the mdxRGT mice was increased 1.8-fold compared to mdxGT mice (no run) and ~5-fold compared to mdx mice (no micro-dystrophin, no …
-
Green tea extract and epigallocatechin gallate decrease muscle pathology and NF-κB immunostaining in regenerating muscle fibers of mdx mice
… muscle pathology and increase muscle function in mdx mice, a dystrophic mouse model. These changes have been attributed to the antioxidant potential of epigallocatechin gallate; however, other mechanisms such as suppression of the inflammatory response have not been evaluated. In the studies …
-
The Majority of the Diaphragm Immune Transcriptome Profile Rescued in Mdx Mice by Microdystrophin Gene Therapy was maintained by Voluntary Wheel Running
… transcriptomic changes in the diaphragm of mdx mice treated with microdystrophin gene therapy with and without running wheel activity. Mdx mice are a model of Duchenne Muscular Dystrophy (DMD). Similar to DMD, mdx pathophysiology is associated with chronic inflammation due to sarcolemma …
-
Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… recent evidence has shown that the DBA/2J (D2) mdx mouse model of DMD presents with cognitive dysfunction and a shift towards amyloid beta (Ab) production in the hippocampus and prefrontal cortex (PFC). However, this was not observed in the traditional, yet less severe model of DMD, the C57BL/10 …
-
Characterizing RyR and SERCA function in the C57 and D2 mdx mouse models of Duchenne Muscular Dystrophy
… in two mouse models of DMD. The D2.B10-Dmdmdx/J (D2 mdx) mouse has emerged as a more pathologically representative model of DMD than the C57BL/10ScSn-Dmdmdx/J (C57 mdx) mouse model, showing greater muscle weakness, wasting and earlier disease onset. However, SR Ca2+ has not yet been …
-
Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… thesis examined mood in the dystrophin-deficient mdx mouse model of DMD and examined the effects of the tri-cyclic antidepressant, amitriptyline on behaviours. Amitriptyline had anti-depressant and anxiolytic effects in the mdx mice possibly through effects on stress factors such as …
-
An Alpha7beta1 Integrin-Based Treatment of Muscular Dystrophy
… system leads to muscular dystrophy in humans and mice. To determine if the integrin complex can compensate for the lack of the dystrophin protein complex, transgenic mice were made to produce elevated levels of the alpha7 integrin chain. The transgene was introduced into two dystrophic …
-
Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… dystrophin. Initially, we used the dystrophic mdx mouse to investigate what impact loss of dystrophin had on normal hippocampal function. Significantly, LTP, the molecular correlate of learning and memory was shown to be decreased in mdx mice, which has been linked to memory dysfunction. …
-
Development of a SNP Assay for the Differentiation of Allelic Variations in the mdx Dystrophic Mouse Model
… the dystrophic and wild type (wt) alleles in mdx mice. The mdx mouse is an animal model for Duchenne muscular dystrophy (DMD), a severe and fatal muscle wasting disease. To evaluate possible treatments and to carry out genetic studies, it is essential to distinguish between mice that carry the …
-
Cellular and molecular regulation of skeletal muscle regeneration
… cell self-renewal in a disease model. The MDX mouse is a well-established model for Duchenne muscular dystrophy (DMD) and characterized by progressive muscle degeneration and regeneration. Here, I showed that the number and activity of satellite cells in MDX mice were reduced in an …
-
Leucine and exercise improve skeletal muscle function in the mdx mouse
… to sedentary and exercised x-linked dystrophic mice (mdx) over 4 weeks would improve skeletal muscle function and decrease markers of skeletal muscle degradation. In sedentary mdx mice, leucine improved tetanic extensor digitorum longus (EDL) stress (p < 0.05), gastrocnemius mammalian target or …
-
The activity and content of calpains in maturing dystrophic muscle membranes
… activity in membranes obtained from dystrophic (mdx; mdx:utrophin-deficient (mdx:utrn-/-)) compared to wildtype (wt) mouse skeletal muscles during maturation at ages 7- and 21-d,and at a post-maturation age of 35-d. Calpain activity was determined as the calcium-dependent cleavage of the …
-
Integrins in muscle disease and repair
… architecture. Furthermore, detailed analysis of mdxα7tg mice suggests that overexpression of integrin α7 made no difference on the dystrophic phenotype, in fact mdx α7X2 mice show a more severe phenotype compared to mdx mice. Our study also shed light on the importance of integrin α5 during the …
-
The growth of murine breast cancer cells in dystrophic mice
… cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary tumors. Results: There were differences in body …
-
Immunolocalization of dystrophin and neurofilament protein in muscle spindles of normal, mdx-dystrophic, and denervated mice
… Duchenne muscular dystrophy patients and in the mdx mouse. Muscle spindles in the soleus of 32-week-old normal and age-matched mdx mice were examined by immunocytochemical methods to determine the localization of dystrophin in polar and equatorial regions of the intrafusal fibers. Spindles were …
-
The Effect of Resveratrol On Skeletal Muscle Function, Muscle Pathology, and Oxidative Capacity In the Mdx Mouse Model of Duchenne Muscular Dystrophy
… capacity, and utrophin protein expression in the mdx mouse model of DMD. Specific aim 1 examined the effect of resveratrol treatment on in-vivo and in-situ muscle function. Resveratrol treatment significantly increased rotarod performance, increased specific peak tension of the triceps surae …
-
Exploring Dystrophin-Mediated Control of Neural Stem Cell Fate Associated with Intellectual Disability In Duchenne Muscular Dystrophy Patients
… commonly used animal model to study DMD is the mdx mouse which completely lacks Dp427 but no other DMD isoforms. Although the muscle phenotype is well-established, behavioural characterization of the mdx mouse model has been inconclusive. In this thesis I investigated the hippocampal and …
Page 1 of 2