Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"mdx"”.
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Force potentiation in the MDX mouse
… to prevent damage in Xlinked muscular dystrophy (mdx) mice since PTP increases force and PTP effects are greatest in IIB fibers. PTP experiments were performed on the extensor digitorum longus (EDL) of 50 day old mdx (YM) and C57BL/10 (YC) mice and 10 month old mdx (OM) and C57B1710 (OC) mice. …
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Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… signature and improve muscle function in mdx mice, a model of DMD. C57BL10 (WT) and mdx mice were fed AIN 76A diet ± 0.1% SM for 7 weeks starting at age 4 weeks (n=10/group: WT, WT + S, mdx, mdx + S). At ages 5, 7, and 9 weeks, ankle flexor torque was determined in vivo. Mice were …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… affected dystrophic tissues using the mdx mouse model; from severely dystrophic diaphragm; moderately affected hind limb to naturally protected interosseus muscle were used to investigate the pathogenesis of the disease. Proteomic analysis of the muscle subtypes indicated that skeletal …
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Leucine and exercise improve skeletal muscle function in the mdx mouse
… and exercised x-linked dystrophic mice (mdx) over 4 weeks would improve skeletal muscle function and decrease markers of skeletal muscle degradation. In sedentary mdx mice, leucine improved tetanic extensor digitorum longus (EDL) stress (p < 0.05), gastrocnemius mammalian target or …
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Proteomic Characterisation of the mdx-4cv mouse model of Duchenne Muscular Dystrophy
… interaction patterns, respectively, in the mdx-4cv animal model of Duchenne muscular dystrophy. Proteins of particular interest have been further verified by biochemical assays including comparative immunoblotting and enzyme-linked immunosorbent assays. In-depth analyses have been performed …
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Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
… resistance in a preclinical model for DMD, the mdx mouse. However, the exact cellular mechanisms leading to these benefits remain unknown and is the purpose of the present thesis. To this end, male muscle-specific GSK3 knockdown mice (C57BL/6J background) were bred with female homozygous D2 mdx …
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Physiological adaptations in mdx mice treated with microdystrophin gene therapy and endurance exercise
… and in vivo plantarflexor torque output in young mdx mice, a mouse model of DMD. Although treated mice could run well, diaphragm force and power output were blunted by VWR. A subsequent study tested longevity of two different microdystrophin gene therapy constructs in combination with VWR. …
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Liposomal verkapselte Glukokortikosteroide in der Therapie der mdx-Maus als Modell der Duchenneschen Muskeldystrophie
… Ziel dieser Arbeit war es, die Therapie von mdx-Mäusen mit liposomal verkapseltem Prednisolon zu untersuchen und mit der Behandlung mit freiem Prednisolon und Kontrollmäusen zu vergleichen. Beide Behandlungen zeigten keine Auswirkungen auf den klinischen Krankheitsverlauf, den dystrophischen …
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Immunolocalization of dystrophin and neurofilament protein in muscle spindles of normal, mdx-dystrophic, and denervated mice
… Duchenne muscular dystrophy patients and in the mdx mouse. Muscle spindles in the soleus of 32-week-old normal and age-matched mdx mice were examined by immunocytochemical methods to determine the localization of dystrophin in polar and equatorial regions of the intrafusal fibers. Spindles were …
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Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… thesis examined mood in the dystrophin-deficient mdx mouse model of DMD and examined the effects of the tri-cyclic antidepressant, amitriptyline on behaviours. Amitriptyline had anti-depressant and anxiolytic effects in the mdx mice possibly through effects on stress factors such as …
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Characterizing RyR and SERCA function in the C57 and D2 mdx mouse models of Duchenne Muscular Dystrophy
… in two mouse models of DMD. The D2.B10-Dmdmdx/J (D2 mdx) mouse has emerged as a more pathologically representative model of DMD than the C57BL/10ScSn-Dmdmdx/J (C57 mdx) mouse model, showing greater muscle weakness, wasting and earlier disease onset. However, SR Ca2+ has not yet been …
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Strengthening Mission through Strategy: An Analysis of the Mission-Driven Excellence Strategy
… in implementing the Mission-driven Excellence (MdX) strategy. MdX combines planning and direction that helps church leaders to think strategically. MdX is a combination of pre-events, processes, and resources combined with local church strategies toward mission. The purpose of this study was to …
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Development of a SNP Assay for the Differentiation of Allelic Variations in the mdx Dystrophic Mouse Model
… the dystrophic and wild type (wt) alleles in mdx mice. The mdx mouse is an animal model for Duchenne muscular dystrophy (DMD), a severe and fatal muscle wasting disease. To evaluate possible treatments and to carry out genetic studies, it is essential to distinguish between mice that carry the …
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Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… dystrophin. Initially, we used the dystrophic mdx mouse to investigate what impact loss of dystrophin had on normal hippocampal function. Significantly, LTP, the molecular correlate of learning and memory was shown to be decreased in mdx mice, which has been linked to memory dysfunction. …
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Potential adaptive signaling pathways in the diaphragm of mdx mice treated with micro-dystrophin combined with voluntary running
… to micro-dystrophin gene therapy (GT) in mdx mice, a model of Duchenne muscular dystrophy (DMD). After 21 weeks of running, time to fatigue on a treadmill for the mdxRGT mice was increased 1.8-fold compared to mdxGT mice (no run) and ~5-fold compared to mdx mice (no micro-dystrophin, no …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… recent evidence has shown that the DBA/2J (D2) mdx mouse model of DMD presents with cognitive dysfunction and a shift towards amyloid beta (Ab) production in the hippocampus and prefrontal cortex (PFC). However, this was not observed in the traditional, yet less severe model of DMD, the C57BL/10 …
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Increased structure-bound proteolytic activity in maturing dystrophic skeletal muscle
… have been reported as early as age 4 weeks in mdx (dystrophin-deficient) mice (Spencer et al., 1995). Increased calpain activity has been demonstrated in mdx myotubes (Alderton et al., 2000a). There is also evidence of a role for calpain in DMD, but the contribution of calpain activity to the …
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Aorta-derived mesoangioblasts for cell therapy of cardiomyopathy in Duchenne Muscular Dystrophy
… cardiomyopathy in murine models for DMD, mdx and mdx/utrn-/- mice, and whether ADM are good candidates for cell-based therapy of DCM in DMD. In the first part of study, mdx/utrn-/- mice were characterized to determine whether they develop DCM similar to patients with DMD as a good disease …
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The Majority of the Diaphragm Immune Transcriptome Profile Rescued in Mdx Mice by Microdystrophin Gene Therapy was maintained by Voluntary Wheel Running
… transcriptomic changes in the diaphragm of mdx mice treated with microdystrophin gene therapy with and without running wheel activity. Mdx mice are a model of Duchenne Muscular Dystrophy (DMD). Similar to DMD, mdx pathophysiology is associated with chronic inflammation due to sarcolemma …
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The growth of murine breast cancer cells in dystrophic mice
… cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary tumors. Results: There were differences in body …
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